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158 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28337317 30 Structural Requirements of HDAC Inhibitors: SAHA Analogues Modified at the C2 Position Display HDAC6/8 Selectivity.EBI Wayne State University
27541357 58 Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines.EBI National University of Singapore
28057407 76 Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase.EBI Georgia Institute of Technology
27344487 16 2-(Phenylsulfonyl)quinoline N-hydroxyacrylamides as potent anticancer agents inhibiting histone deacetylase.EBI Taipei Medical University
27717544 75 Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors.EBI Integral BioSciences Pvt. Ltd
27665180 14 Design and synthesis of novel HDAC8 inhibitory 2,5-disubstituted-1,3,4-oxadiazoles containing glycine and alanine hybrids with anti cancer activity.EBI Acharya Nagarjuna University
27606546 218 Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.EBI University of Navarra
27377864 55 Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.EBI Broad Institute of MIT and Harvard
27186676 186 Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities.EBI West China Hospital of Sichuan University
26890116 30 Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity.EBI University of Milan
27060764 30 Computer-aided identification of new histone deacetylase 6 selective inhibitor with anti-sepsis activity.EBI Sungkyunkwan University
26443078 108 Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer.EBI Sichuan University
26907204 34 Design and synthesis of a new generation of substituted purine hydroxamate analogs as histone deacetylase inhibitors.EBI Shandong University
26705137 31 Design, Synthesis, and Pharmacological Evaluation of Novel N-Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors.EBI Universidade Federal de Alfenas
26814680 71 Identification of N-(6-mercaptohexyl)-3-(4-pyridyl)-1H-pyrazole-5-carboxamide and its disulfide prodrug as potent histone deacetylase inhibitors with in vitro and in vivo anti-tumor efficacy.EBI Shenyang Pharmaceutical University
26804233 38 Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation.EBI Massachusetts General Hospital
26706171 138 Novel thiol-based histone deacetylase inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif: Design, synthesis and SAR study.EBI Shenyang Pharmaceutical University
26689485 18 Orally available stilbene derivatives as potent HDAC inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.EBI Orchid Chemicals& Pharmaceuticals Ltd
26741358 56 Design, synthesis and biological evaluation of N-phenylquinazolin-4-amine hybrids as dual inhibitors of VEGFR-2 and HDAC.EBI China Pharmaceutical University
26629860 58 Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors.EBI European Institute of Oncology
26753813 22 Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid.EBI University of Minnesota
26475519 40 Hybrids from 4-anilinoquinazoline and hydroxamic acid as dual inhibitors of vascular endothelial growth factor receptor-2 and histone deacetylase.EBI China Pharmaceutical University
26376355 14 Investigation on the ZBG-functionality of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase inhibitors.EBI University of Milan
26331334 99 Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities.EBI Guangzhou Institute of Biomedicine and Health
26264503 46 Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.EBI University of Minnesota
26287310 87 Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.EBI University College London
25637120 94 Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).EBI St Jude Children's Research Hospital
22344701 30 Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat (LBH589).EBI Novartis Institutes for BioMedical Research
25147612 25 Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties.EBI University of Florida
26054247 48 Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole.EBI Colorado State University
25953722 102 Discovery, bioactivity and docking simulation of Vorinostat analogues containing 1,2,4-oxadiazole moiety as potent histone deacetylase inhibitors and antitumor agents.EBI Southeast University
25974739 17 Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release.EBI University of California
25815139 18 Discovery of Novel Multiacting Topoisomerase I/II and Histone Deacetylase Inhibitors.EBI Fujian University of Traditional Chinese Medicine
25971769 25 Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors.EBI MethylGene Inc.
25906087 14 Design, synthesis, and antitumor evaluation of novel histone deacetylase inhibitors equipped with a phenylsulfonylfuroxan module as a nitric oxide donor.EBI Shandong University
25905694 24 Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells.EBI Istituto Ortopedico Rizzoli (IOR)
25874326 60 Discovery and preliminary evaluation of 2-aminobenzamide and hydroxamate derivatives containing 1,2,4-oxadiazole moiety as potent histone deacetylase inhibitors.EBI Southeast University
25805446 30 Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.EBI East China Normal University
25070421 33 Evaluation of class I HDAC isoform selectivity of largazole analogues.EBI Duke University
25042254 7 Novel inhibitors of human histone deacetylases: design, synthesis and bioactivity of 3-alkenoylcoumarines.EBI H�pital Kirchberg
24864038 112 Design and synthesis of novel and highly-active pan-histone deacetylase (pan-HDAC) inhibitors.EBI Nippon Pharmaceutical Chemicals Co., Ltd
25563890 49 Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.EBI R&D Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
25462271 33 Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity.EBI Shandong University
25455492 22 Aurones as histone deacetylase inhibitors: identification of key features.EBI University of Geneva
25454270 82 Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform.EBI TBA
25380299 61 Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles.EBI Technical University of Denmark
25238284 52 Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors.EBI Roche Pharmaceutical Research and Early Development
25233084 247 ST7612AA1, a thioacetate-(-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors.EBI R&D Sigma-Tau Industrie Farmaceutiche Riunite SpA
25218912 103 Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors.EBI Chinese Academy of Sciences
24766560 16 Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells.EBI Taipei Medical University
24588105 56 Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold.EBI Universit£ degli Studi di Siena
24565573 35 4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors.EBI Universit£ degli Studi di Ferrara
24742384 90 Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors.EBI Universit£ di Milano
24694055 35 Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity.EBI Shandong University
23570542 48 Design and synthesis of dual-action inhibitors targeting histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme A reductase for cancer treatment.EBI National Taiwan University
23368884 80 Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.EBI Broad Institute of MIT and Harvard
23252603 35 Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells.EBI Heinrich Heine Universit£t
23116147 30 Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries.EBI Kyoto Prefectural University of Medicine
23061376 63 Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response.EBI Roche R&D Center-China Ltd.
23009203 39 Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.EBI University of Illinois at Chicago
23010266 24 Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose.EBI University of Illinois at Chicago
22642300 160 Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.EBI Kyoto Prefectural University of Medicine
22771007 64 Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2.EBI University of Illinois at Chicago
22705022 32 Synthesis, biological evaluation and molecular docking studies of 3-(1,3-diphenyl-1H-pyrazol-4-yl)-N-phenylacrylamide derivatives as inhibitors of HDAC activity.EBI Nanjing University
22439863 21 Synthesis and biological evaluation of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo.EBI Taipei Medical University
22465091 28 A novel series of l-2-benzyloxycarbonylamino-8-(2-pyridyl)-disulfidyloctanoic acid derivatives as histone deacetylase inhibitors: design, synthesis and molecular modeling study.EBI Dalian University of Technology
21874153 54 Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.EBI Broad Institute of Harvard and MIT
20472442 25 On the inhibition of histone deacetylase 8.EBI University of Notre Dame
20452225 49 Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids.EBI McGill University
18809328 64 Optimization of a series of potent and selective ketone histone deacetylase inhibitors.EBI IRBM/Merck Research Laboratories
18182289 127 Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).EBI Merck Research Laboratories
18247554 134 Histone deacetylase inhibitors: from bench to clinic.EBI Menarini Ricerche
16987657 45 A series of novel, potent, and selective histone deacetylase inhibitors.EBI IRBM/Merck Research Laboratories
14613312 106 Histone deacetylase inhibitors.EBI Aton Pharma, Inc
22321215 16 Anti-tumor activity of new orally bioavailable 2-amino-5-(thiophen-2-yl)benzamide-series histone deacetylase inhibitors, possessing an aqueous soluble functional group as a surface recognition domain.EBI Kansai University
21721525 8 In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid (18F-SAHA).EBI Harvard Medical School
21548582 57 Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes.EBI University of Illinois at Chicago
21634430 218 Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.EBI S*BIO Pte Ltd.
21723733 12 Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors.EBI Novartis Institutes for Biomedical Research
21696956 243 A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.EBI Broad Institute of Harvard and MIT
21080647 27 Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor.EBI Chroma Therapeutics Ltd.
21334896 18 Discovery of histone deacetylase 8 selective inhibitors.EBI Howard Hughes Medical Institute
21417297 220 Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation.EBI Universita` degli Studi di Siena
21256006 11 Structure and property based design, synthesis and biological evaluation of¿-lactam based HDAC inhibitors.EBI Yonsei University
21145737 12 Application of p21 and klf2 reporter gene assays to identify selective histone deacetylase inhibitors for cancer therapy.EBI Roche R&D Center China Ltd
19966789 40 Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.EBI The Scripps Research Institute
20637529 15 Design and synthesis of novel isoxazole-based HDAC inhibitors.EBI Università degli Studi di Milano
20223566 23 Inside HDAC with HDAC inhibitors.EBI Universit£ de Poitiers
20451378 107 Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity.EBI S *BIO Pte Ltd
20392638 40 Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides.EBI Takeda San Diego
20381359 17 Synthesis and biological activity of cyclotetrapeptide analogues of the natural HDAC inhibitor FR235222.EBI Universit£ degli Studi di Salerno
20205394 44 Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824).EBI Novartis Institutes for Biomedical Research
20055418 78 Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents.EBI University of Illinois at Chicago
20143778 70 Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer.EBI Curis Inc
19906529 22 Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.EBI Ortho-Biotech Oncology Research& Development
19699639 58 Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.EBI MethylGene Inc.
19359173 51 Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors.EBI Sigma-Tau Research and Development
19084294 19 Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.EBI Universit£ di Milano
19441846 35 Discovery of a potent class I selective ketone histone deacetylase inhibitor with antitumor activity in vivo and optimized pharmacokinetic properties.EBI IRBM/Merck Research Laboratories
19419863 58 Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity.EBI University of Illinois at Chicago
19419205 28 Design, synthesis, and biological activity of boronic acid-based histone deacetylase inhibitors.EBI Nagoya City University
19410459 33 Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model.EBI IRBM/Merck Research Laboratories
19285395 66 N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors.EBI R&D Sigma-Tau SpA
19268585 30 Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2).EBI Merck Research Laboratories
19181524 46 N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.EBI S *BIO Pte Ltd
19114304 44 SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).EBI MethylGene Inc.
19111466 42 Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors.EBI MethylGene Inc
18951790 109 SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2).EBI Merck Research Laboratories
18672316 41 Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR.EBI Institute of Organic Synthesis
18642892 76 Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.EBI University of Illinois at Chicago
18060775 67 Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2).EBI Merck Research Laboratories
17892933 10 Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence.EBI Université de Montréal
17761416 53 The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors.EBI Merck Research Laboratories
17555962 26 Design of novel histone deacetylase inhibitors.EBI Merck Research Laboratories
17539623 65 Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies.EBI University of Illinois at Chicago
16137884 6 Design and synthesis of phthalimide-type histone deacetylase inhibitors.EBI The University of Tokyo Yayoi
14698179 49 Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group.EBI The Scripps Research Institute
28196602 16 Novel N-hydroxybenzamides incorporating 2-oxoindoline with unexpected potent histone deacetylase inhibitory effects and antitumor cytotoxicity.BDB Hanoi University of Pharmacy
24114842 25 The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity.BDB Soochow University
23897821 60 Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability.BDB Genentech, Inc.
27977115 24 LSD1 Substrate Binding and Gene Expression Are Affected by HDAC1-Mediated Deacetylation.BDB Wayne State University
27454931 24 Structural insights into HDAC6 tubulin deacetylation and its selective inhibition.BDB Friedrich Miescher Institute for Biomedical Research
27064299 8 Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile.BDB Broad Institute
26640968 60 An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in -Cell Protection.BDB Broad Institute of Harvard and MIT
25699604 74 Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases.BDB University of Florida College of Medicine; Northwest Agriculture and Forestry University
23581848 8 Design and synthesis of a tetrahydroisoquinoline-based hydroxamate derivative (ZYJ-34v), an oral active histone deacetylase inhibitor with potent antitumor activity.BDB Shandong University
18370373 48 A novel series of potent and selective ketone histone deacetylase inhibitors with antitumor activity in vivo.BDB IRBM/Merck
18570366 9 Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.BDB MethylGene Inc.
16731764 10 CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo.BDB Celera Genomics
18494463 106 A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum.BDB University of Illinois at Chicago
17941625 50 Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity.BDB MethylGene Inc