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151 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28337317 30 Structural Requirements of HDAC Inhibitors: SAHA Analogues Modified at the C2 Position Display HDAC6/8 Selectivity.EBI Wayne State University
28057407 76 Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase.EBI Georgia Institute of Technology
27717544 75 Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors.EBI Integral BioSciences Pvt. Ltd
27665180 14 Design and synthesis of novel HDAC8 inhibitory 2,5-disubstituted-1,3,4-oxadiazoles containing glycine and alanine hybrids with anti cancer activity.EBI Acharya Nagarjuna University
27606546 218 Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.EBI University of Navarra
27377864 55 Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.EBI Broad Institute of MIT and Harvard
27190592 24 Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs.EBI IRBM Science Park
27177826 2 Synergistic potentiation of (-)-lomaiviticin A cytotoxicity by the ATR inhibitor VE-821.EBI Yale University
26443078 108 Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer.EBI Sichuan University
26890114 56 Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy.EBI Shanghai Institute of Materia Medica
26681404 40 Design and Synthesis of Simplified Largazole Analogues as Isoform-Selective Human Lysine Deacetylase Inhibitors.EBI Washington University School of Medicine
26814680 71 Identification of N-(6-mercaptohexyl)-3-(4-pyridyl)-1H-pyrazole-5-carboxamide and its disulfide prodrug as potent histone deacetylase inhibitors with in vitro and in vivo anti-tumor efficacy.EBI Shenyang Pharmaceutical University
26804233 38 Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation.EBI Massachusetts General Hospital
26706171 138 Novel thiol-based histone deacetylase inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif: Design, synthesis and SAR study.EBI Shenyang Pharmaceutical University
26689485 18 Orally available stilbene derivatives as potent HDAC inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.EBI Orchid Chemicals& Pharmaceuticals Ltd
26629860 58 Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors.EBI European Institute of Oncology
26753813 22 Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid.EBI University of Minnesota
26331334 99 Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities.EBI Guangzhou Institute of Biomedicine and Health
26086931 38 Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators.EBI Shandong University
26264503 46 Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.EBI University of Minnesota
26211462 71 Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors.EBI The Walter and Eliza Hall Institute of Medical Research
25637120 94 Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).EBI St Jude Children's Research Hospital
22344701 30 Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat (LBH589).EBI Novartis Institutes for BioMedical Research
25147612 25 Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties.EBI University of Florida
25261927 80 Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors.EBI The Walter and Eliza Hall Institute of Medical Research
26054247 48 Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole.EBI Colorado State University
26100440 6 Design, synthesis and preliminary biological evaluation of indoline-2,3-dione derivatives as novel HDAC inhibitors.EBI Shandong University
25974739 17 Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release.EBI University of California
25906087 14 Design, synthesis, and antitumor evaluation of novel histone deacetylase inhibitors equipped with a phenylsulfonylfuroxan module as a nitric oxide donor.EBI Shandong University
25905694 24 Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells.EBI Istituto Ortopedico Rizzoli (IOR)
25805446 30 Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.EBI East China Normal University
25070421 33 Evaluation of class I HDAC isoform selectivity of largazole analogues.EBI Duke University
25042254 7 Novel inhibitors of human histone deacetylases: design, synthesis and bioactivity of 3-alkenoylcoumarines.EBI H�pital Kirchberg
24864038 112 Design and synthesis of novel and highly-active pan-histone deacetylase (pan-HDAC) inhibitors.EBI Nippon Pharmaceutical Chemicals Co., Ltd
25563890 49 Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.EBI R&D Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
25462271 33 Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity.EBI Shandong University
25454270 82 Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform.EBI TBA
25380299 61 Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles.EBI Technical University of Denmark
25238284 52 Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors.EBI Roche Pharmaceutical Research and Early Development
25233084 247 ST7612AA1, a thioacetate-(-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors.EBI R&D Sigma-Tau Industrie Farmaceutiche Riunite SpA
25218912 103 Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors.EBI Chinese Academy of Sciences
24944733 101 Potent and orally efficacious bisthiazole-based histone deacetylase inhibitors.EBI Chinese National Center for Drug Screening
24742384 90 Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors.EBI Universit£ di Milano
24694055 35 Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity.EBI Shandong University
24261862 23 Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease.EBI BioFocus
24328302 94 Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.EBI Heinrich-Heine-Universit£t D£sseldorf
24095018 24 The discovery and optimization of novel dual inhibitors of topoisomerase II and histone deacetylase.EBI East China Normal University
24035339 4 Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs.EBI Colorado State University
23964961 9 Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N-hydroxybenzamide with high selectivity for the HDAC6 isoform.EBI Millennium Pharmaceuticals, Inc.
23627282 10 Development and therapeutic implications of selective histone deacetylase 6 inhibitors.EBI University of Illinois at Chicago
23906422 1 Identification of novel HDAC inhibitors through cell based screening and their evaluation as potential anticancer agents.EBI Translational Drug Development, Inc
23829483 32 Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.EBI University College London
23644210 5 Synthesis and biological characterization of spiro[2H-(1,3)-benzoxazine-2,4'-piperidine] based histone deacetylase inhibitors.EBI Congenia s.r.l.
23602523 5 The discovery of colchicine-SAHA hybrids as a new class of antitumor agents.EBI East China Normal University
23591111 2 A cyclodextrin-capped histone deacetylase inhibitor.EBI University of Sussex
23672185 3 Discovery of the first histone deacetylase 6/8 dual inhibitors.EBI Broad Institute of MIT and Harvard
23368884 80 Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.EBI Broad Institute of MIT and Harvard
23089527 6 The structural requirements of histone deacetylase inhibitors: suberoylanilide hydroxamic acid analogs modified at the C6 position.EBI Wayne State University
23061376 63 Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response.EBI Roche R&D Center-China Ltd.
23009203 39 Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.EBI University of Illinois at Chicago
23010266 24 Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose.EBI University of Illinois at Chicago
22642300 160 Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.EBI Kyoto Prefectural University of Medicine
22738629 47 CCLab--a multi-objective genetic algorithm based combinatorial library design software and an application for histone deacetylase inhibitor design.EBI Chinese Academy of Sciences
22541394 30 Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors.EBI Guru Ghasidas University
21874153 54 Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.EBI Broad Institute of Harvard and MIT
20472442 25 On the inhibition of histone deacetylase 8.EBI University of Notre Dame
20452225 49 Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids.EBI McGill University
19705846 100 Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides.EBI The Scripps Research Institute
18809328 64 Optimization of a series of potent and selective ketone histone deacetylase inhibitors.EBI IRBM/Merck Research Laboratories
17956988 14 Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.EBI Istituto di Ricerche di Biologia Molecolare
18182289 127 Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).EBI Merck Research Laboratories
18247554 134 Histone deacetylase inhibitors: from bench to clinic.EBI Menarini Ricerche
16987657 45 A series of novel, potent, and selective histone deacetylase inhibitors.EBI IRBM/Merck Research Laboratories
21417419 5 Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors.EBI DAC SRL
21721525 8 In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid (18F-SAHA).EBI Harvard Medical School
21889343 6 The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity.EBI Wayne State University
21634430 218 Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.EBI S*BIO Pte Ltd.
21745740 10 Synthesis and biological evaluation of piperamide analogues as HDAC inhibitors.EBI East China Normal University
21696956 243 A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.EBI Broad Institute of Harvard and MIT
21080647 27 Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor.EBI Chroma Therapeutics Ltd.
21417297 220 Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation.EBI Universita` degli Studi di Siena
21256006 11 Structure and property based design, synthesis and biological evaluation of¿-lactam based HDAC inhibitors.EBI Yonsei University
21145737 12 Application of p21 and klf2 reporter gene assays to identify selective histone deacetylase inhibitors for cancer therapy.EBI Roche R&D Center China Ltd
21080629 153 Novel chimeric histone deacetylase inhibitors: a series of lapatinib hybrides as potent inhibitors of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and histone deacetylase activity.EBI University of Regensburg
19966789 40 Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.EBI The Scripps Research Institute
20637529 15 Design and synthesis of novel isoxazole-based HDAC inhibitors.EBI Università degli Studi di Milano
20223566 23 Inside HDAC with HDAC inhibitors.EBI Universit£ de Poitiers
20451378 107 Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity.EBI S *BIO Pte Ltd
20381359 17 Synthesis and biological activity of cyclotetrapeptide analogues of the natural HDAC inhibitor FR235222.EBI Universit£ degli Studi di Salerno
20205394 44 Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824).EBI Novartis Institutes for Biomedical Research
20143840 28 Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short alkyl groups on the phenyl ring.EBI UMR CNRS 6026-Universit£ Rennes 1
20055418 78 Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents.EBI University of Illinois at Chicago
20143778 70 Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer.EBI Curis Inc
19906529 22 Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.EBI Ortho-Biotech Oncology Research& Development
19359173 51 Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors.EBI Sigma-Tau Research and Development
19362838 16 Design and synthesis of novel hybrid benzamide-peptide histone deacetylase inhibitors.EBI The Scripps Research Institute
19441846 35 Discovery of a potent class I selective ketone histone deacetylase inhibitor with antitumor activity in vivo and optimized pharmacokinetic properties.EBI IRBM/Merck Research Laboratories
19419863 58 Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity.EBI University of Illinois at Chicago
19410459 33 Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model.EBI IRBM/Merck Research Laboratories
19285395 66 N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors.EBI R&D Sigma-Tau SpA
19268585 30 Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2).EBI Merck Research Laboratories
19181524 46 N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.EBI S *BIO Pte Ltd
19114304 44 SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).EBI MethylGene Inc.
18952417 50 Studies of the metabolic stability in cells of 5-(trifluoroacetyl)thiophene-2-carboxamides and identification of more stable class II histone deacetylase (HDAC) inhibitors.EBI IRBM-Merck Research Laboratories Rome
18951790 109 SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2).EBI Merck Research Laboratories
18930398 117 2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors.EBI IRBM-Merck Research Laboratories Rome
18672316 41 Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR.EBI Institute of Organic Synthesis
18642892 76 Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.EBI University of Illinois at Chicago
18060775 67 Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2).EBI Merck Research Laboratories
17761416 53 The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors.EBI Merck Research Laboratories
17691763 20 2-aroylindoles and 2-aroylbenzofurans with N-hydroxyacrylamide substructures as a novel series of rationally designed histone deacetylase inhibitors.EBI University of Regensburg
17606370 2 Trithiocarbonates: exploration of a new head group for HDAC inhibitors.EBI Altana Pharma AG
17555962 26 Design of novel histone deacetylase inhibitors.EBI Merck Research Laboratories
24114842 25 The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity.BDB Soochow University
23897821 60 Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability.BDB Genentech, Inc.
27977115 24 LSD1 Substrate Binding and Gene Expression Are Affected by HDAC1-Mediated Deacetylation.BDB Wayne State University
27454931 24 Structural insights into HDAC6 tubulin deacetylation and its selective inhibition.BDB Friedrich Miescher Institute for Biomedical Research
27064299 8 Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile.BDB Broad Institute
26640968 60 An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in -Cell Protection.BDB Broad Institute of Harvard and MIT
25699604 74 Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases.BDB University of Florida College of Medicine; Northwest Agriculture and Forestry University
23581848 8 Design and synthesis of a tetrahydroisoquinoline-based hydroxamate derivative (ZYJ-34v), an oral active histone deacetylase inhibitor with potent antitumor activity.BDB Shandong University
19138845 44 Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization.BDB Merck Research Laboratories
18440229 175 2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors.BDB IRBM/Merck
18308563 39 Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.BDB IRBM/Merck
18370373 48 A novel series of potent and selective ketone histone deacetylase inhibitors with antitumor activity in vivo.BDB IRBM/Merck
18570366 9 Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.BDB MethylGene Inc.
16731764 10 CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo.BDB Celera Genomics
18494463 106 A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum.BDB University of Illinois at Chicago
17941625 50 Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity.BDB MethylGene Inc