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118 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27377864 55 Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.EBI Broad Institute of MIT and Harvard
27186676 186 Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities.EBI West China Hospital of Sichuan University
26890116 30 Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity.EBI University of Milan
26819662 13 Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors.EBI BioFocus
27060764 30 Computer-aided identification of new histone deacetylase 6 selective inhibitor with anti-sepsis activity.EBI Sungkyunkwan University
26443078 108 Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer.EBI Sichuan University
26890114 56 Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy.EBI Shanghai Institute of Materia Medica
26814680 71 Identification of N-(6-mercaptohexyl)-3-(4-pyridyl)-1H-pyrazole-5-carboxamide and its disulfide prodrug as potent histone deacetylase inhibitors with in vitro and in vivo anti-tumor efficacy.EBI Shenyang Pharmaceutical University
26706171 138 Novel thiol-based histone deacetylase inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif: Design, synthesis and SAR study.EBI Shenyang Pharmaceutical University
26689485 18 Orally available stilbene derivatives as potent HDAC inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.EBI Orchid Chemicals& Pharmaceuticals Ltd
26753813 22 Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid.EBI University of Minnesota
26331334 99 Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities.EBI Guangzhou Institute of Biomedicine and Health
26086931 38 Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators.EBI Shandong University
26264503 46 Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.EBI University of Minnesota
26287310 87 Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.EBI University College London
25637120 94 Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).EBI St Jude Children's Research Hospital
22344701 30 Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat (LBH589).EBI Novartis Institutes for BioMedical Research
25147612 25 Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties.EBI University of Florida
25906087 14 Design, synthesis, and antitumor evaluation of novel histone deacetylase inhibitors equipped with a phenylsulfonylfuroxan module as a nitric oxide donor.EBI Shandong University
25905694 24 Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells.EBI Istituto Ortopedico Rizzoli (IOR)
25022972 24 Bicyclic tetrapeptides as potent HDAC inhibitors: effect of aliphatic loop position and hydrophobicity on inhibitory activity.EBI University of Rajshahi
24997578 41 Design and synthesis of CHAP31, trapoxin B and HC-toxin based bicyclic tetrapeptides disulfide as potent histone deacetylase inhibitors.EBI University of Rajshahi
24972008 36 1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells.EBI Sapienza University of Rome
24864038 112 Design and synthesis of novel and highly-active pan-histone deacetylase (pan-HDAC) inhibitors.EBI Nippon Pharmaceutical Chemicals Co., Ltd
25462271 33 Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity.EBI Shandong University
25454270 82 Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform.EBI TBA
25238284 52 Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors.EBI Roche Pharmaceutical Research and Early Development
25221651 12 Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity.EBI University of Bologna
25218912 103 Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors.EBI Chinese Academy of Sciences
24588105 56 Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold.EBI Universit£ degli Studi di Siena
24565573 35 4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors.EBI Universit£ degli Studi di Ferrara
24742384 90 Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors.EBI Universit£ di Milano
24694055 35 Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity.EBI Shandong University
17196388 12 Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans.EBI Universit£ degli Studi di Roma La Sapienza
23368884 80 Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.EBI Broad Institute of MIT and Harvard
23252603 35 Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells.EBI Heinrich Heine Universit£t
23116147 30 Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries.EBI Kyoto Prefectural University of Medicine
23061376 63 Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response.EBI Roche R&D Center-China Ltd.
23009203 39 Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.EBI University of Illinois at Chicago
23021104 32 Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases.EBI Graduate School of Life Science and Systems Engineering
22642300 160 Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.EBI Kyoto Prefectural University of Medicine
22541394 30 Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors.EBI Guru Ghasidas University
21874153 54 Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.EBI Broad Institute of Harvard and MIT
18809328 64 Optimization of a series of potent and selective ketone histone deacetylase inhibitors.EBI IRBM/Merck Research Laboratories
17956988 14 Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.EBI Istituto di Ricerche di Biologia Molecolare
18397826 18 Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells.EBI Waseda University
18381238 4 Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities.EBI Sapienza Universit£ di Roma
18182289 127 Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).EBI Merck Research Laboratories
18247554 134 Histone deacetylase inhibitors: from bench to clinic.EBI Menarini Ricerche
16987657 45 A series of novel, potent, and selective histone deacetylase inhibitors.EBI IRBM/Merck Research Laboratories
15454224 15 Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones.EBI CREST Research Project
14613312 106 Histone deacetylase inhibitors.EBI Aton Pharma, Inc
14584932 23 Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A.EBI Universit£ degli Studi di Roma"La Sapienza"
21417419 5 Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors.EBI DAC SRL
21548582 57 Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes.EBI University of Illinois at Chicago
21875805 5 Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase I and histone deacetylase 8.EBI Drexel University
21793558 39 Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities.EBI University of Wisconsin-Milwaukee
21634430 218 Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.EBI S*BIO Pte Ltd.
21712146 20 Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors.EBI Taipei Medical University
21696956 243 A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.EBI Broad Institute of Harvard and MIT
21417297 220 Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation.EBI Universita` degli Studi di Siena
21256006 11 Structure and property based design, synthesis and biological evaluation of¿-lactam based HDAC inhibitors.EBI Yonsei University
19966789 40 Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.EBI The Scripps Research Institute
20491440 12 Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues.EBI Universidade de Vigo
20451378 107 Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity.EBI S *BIO Pte Ltd
20381359 17 Synthesis and biological activity of cyclotetrapeptide analogues of the natural HDAC inhibitor FR235222.EBI Universit£ degli Studi di Salerno
20205394 44 Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824).EBI Novartis Institutes for Biomedical Research
20045316 18 Bicyclic peptides as potent inhibitors of histone deacetylases: optimization of alkyl loop length.EBI Graduate School of Life Science and Systems Engineering
20143778 70 Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer.EBI Curis Inc
19906529 22 Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.EBI Ortho-Biotech Oncology Research& Development
19822426 4 Novel N-hydroxybenzamide-based HDAC inhibitors with branched CAP group.EBI China Pharmaceutical University
19699639 58 Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.EBI MethylGene Inc.
19359173 51 Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors.EBI Sigma-Tau Research and Development
19410459 33 Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model.EBI IRBM/Merck Research Laboratories
19285395 66 N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors.EBI R&D Sigma-Tau SpA
19268585 30 Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2).EBI Merck Research Laboratories
19181524 46 N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.EBI S *BIO Pte Ltd
18951790 109 SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2).EBI Merck Research Laboratories
18930398 117 2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors.EBI IRBM-Merck Research Laboratories Rome
18701301 38 Design, synthesis and biological evaluation of novel compounds with conjugated structure as anti-tumor agents.EBI China Pharmaceutical University
18672316 41 Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR.EBI Institute of Organic Synthesis
18060775 67 Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2).EBI Merck Research Laboratories
17900911 21 Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides.EBI Graduate School of Life Science and Systems Engineering
17881232 42 Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework.EBI Graduate School of Life Science and Systems Engineering
17588744 18 Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.EBI The University of Tokyo
17447750 4 Bispyridinium dienes: histone deacetylase inhibitors with selective activities.EBI Universidade de Vigo
16884291 12 Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate.EBI Nagoya City University
16137884 6 Design and synthesis of phthalimide-type histone deacetylase inhibitors.EBI The University of Tokyo Yayoi
24114842 25 The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity.BDB Soochow University
23897821 60 Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability.BDB Genentech, Inc.
27977115 24 LSD1 Substrate Binding and Gene Expression Are Affected by HDAC1-Mediated Deacetylation.BDB Wayne State University
27416889 35 Design, synthesis, and preliminary bioactivity evaluation of N(1) -hydroxyterephthalamide derivatives with indole cap as novel histone deacetylase inhibitors.BDB Shandong University
27235003 10 PXD101 analogs with L-phenylglycine-containing branched cap as histone deacetylase inhibitors.BDB Shandong University
27454931 24 Structural insights into HDAC6 tubulin deacetylation and its selective inhibition.BDB Friedrich Miescher Institute for Biomedical Research
27064299 8 Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile.BDB Broad Institute
26640968 60 An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in -Cell Protection.BDB Broad Institute of Harvard and MIT
25699604 74 Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases.BDB University of Florida College of Medicine; Northwest Agriculture and Forestry University
25797804 18 An efficient synthesis of SK-658 and its analogs as potent histone deacetylase inhibitors.BDB Kyushu Institute of Technology
20139990 8 Chemical phylogenetics of histone deacetylases.BDB Dana-Farber Cancer Institute
18440229 175 2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors.BDB IRBM/Merck
18308563 39 Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.BDB IRBM/Merck
18370373 48 A novel series of potent and selective ketone histone deacetylase inhibitors with antitumor activity in vivo.BDB IRBM/Merck
18570366 9 Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.BDB MethylGene Inc.
16439135 24 Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases.BDB Kyushu Institute of Technology
17929798 57 Design, synthesis, structure-selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors.BDB Nagoya City University