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182 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27676089 35 A Cyclic Tetrapeptide ("Cyclodal") and Its Mirror-Image Isomer Are Both High-AffinityÁ Opioid Receptor Antagonists.EBI Clinical Research Institute of Montreal
27301366 30 [Dmt(1)]DALDA analogues modified with tyrosine analogues at position 1.EBI Nanjing Medical University
27035422 46 Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain.EBI Vrije Universiteit Brussel
27234885 31 Evaluation of N-substituent structural variations in opioid receptor profile of LP1.EBI University of Catania
26713106 59 Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics.EBI Vrije Universiteit Brussel
26656913 85 Multitarget opioid ligands in pain relief: New players in an old game.EBI University of Catania
26712115 36 Design synthesis and structure-activity relationship of 5-substituted (tetrahydronaphthalen-2yl)methyl with N-phenyl-N-(piperidin-2-yl)propionamide derivatives as opioid ligands.EBI University of Arizona
26330078 51 Synthesis and biological evaluation of 2-alkyl-2-methoxymethyl-salvinorin ethers as selective┐-opioid receptor agonists.EBI Harvard Medical School
26323872 49 Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives.EBI University of Arizona
26299827 43 Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands.EBI University of Arizona
26346669 53 Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain.EBI University of Tsukuba
26252963 15 Novel diazabicycloalkane delta opioid agonists.EBI Istituto di Farmacologia Traslazionale
25283554 43 Design, synthesis, and structure-activity relationship of novel opioid┐ receptor selective agonists:a-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton.EBI Kitasato University
25147605 52 Synthesis and Pharmacology of a Novel┐ Opioid Receptor (KOR) Agonist with a 1,3,5-Trioxazatriquinane Skeleton.EBI Kitasato University
25129170 20 'Carba'-carfentanil (trans isomer): aÁ opioid receptor (MOR) partial agonist with a distinct binding mode.EBI Clinical Research Institute of Montreal
25544687 60 Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.EBI Vrije Universiteit Brussel
25783191 87 Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14▀-dihydroxy-4,5a-epoxy-6a-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands.EBI Virginia Commonwealth University
25562563 18 Methoxyflavones from Stachys glutinosa with binding affinity to opioid receptors: in silico, in vitro, and in vivo studies.EBI National Research Council
25248680 67 Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies.EBI Kitasato University
25221662 24 Novel cyclic biphalin analogue with improved antinociceptive properties.EBI Universit£ di Chieti-Pescara"G. d'Annunzio"
24613457 64 Endomorphin analogues with mixedÁ-opioid (MOP) receptor agonism/d-opioid (DOP) receptor antagonism and lacking▀-arrestin2 recruitment activity.EBI Nanjing Medical University
24602401 40 [Dmt(1)]DALDA analogues with enhancedÁ opioid agonist potency and with a mixedÁ/┐ opioid activity profile.EBI Nanjing Medical University
23547584 19 Biological active analogues of the opioid peptide biphalin: mixeda/ß(3)-peptides.EBI Universit£ di Chieti-Pescara"G. d'Annunzio"
23360448 18 Development of¿ opioid receptor antagonists.EBI Research Triangle Institute
23200250 36 The effect of 17-N substituents on the activity of the opioid¿ receptor in nalfurafine derivatives.EBI Kitasato University
16290934 51 Highly potent and selective zwitterionic agonists of the delta-opioid receptor. Part 1.EBI Pfizer Global Research and Development
7154003 7 A quantitative structure-activity relationship study of the inhibitory action of a series of enkephalin-like peptides in the guinea pig ileum and mouse vas deferens bioassays.EBI TBA
11133082 7 Assessment of substitution in the second pharmacophore of Dmt-Tic analogues.EBI University of Naples
23131341 50 Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet).EBI Kitasato University
23116891 15 Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: part 3, novel propellane derivatives with pentacyclic skeletons.EBI Kitasato University
23103094 39 Essential structure of opioid¿ receptor agonist nalfurafine for binding to the¿ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies.EBI Kitasato University
22325949 28 Novel TIPP (H-Tyr-Tic-Phe-Phe-OH) analogues displaying a wide range of efficacies at thed opioid receptor. Discovery of two highly potent and selectived opioid agonists.EBI Clinical Research Institute of Montreal
23102273 60 Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution.EBI Vrije Universiteit Brussel
22966938 20 cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues: part 2.EBI Universit£ di Chieti-Pescara G. d'Annunzio
22734622 78 Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associatedµ opioid receptor (MOR-1) splice variants.EBI Memorial Sloan-Kettering Cancer Center
22724433 76 A new class of highly potent and selective endomorphin-1 analogues containinga-methylene-ß-aminopropanoic acids (map).EBI Lanzhou University
22967810 102 Synthesis of quinolinomorphinan derivatives as highly selectived opioid receptor ligands.EBI Kitasato University
22742909 24 Essential structure of opioid¿ receptor agonist nalfurafine for binding to the¿ receptor 2: synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies.EBI Kitasato University
22445285 26 Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton and their pharmacologies.EBI Kitasato University
21128594 93 Development of potent Á and d opioid agonists with high lipophilicity.EBI University of Arizona
20547453 122 Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain.EBI University of Arizona
20218625 27 "Carba"-analogues of fentanyl are opioid receptor agonists.EBI Clinical Research Institute of Montreal
20560643 71 Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists.EBI University of Arizona
19211245 27 Synthesis and biological evaluation of C-12 triazole and oxadiazole analogs of salvinorin A.EBI Harvard Medical School
18990576 11 Synthesis of a novel 6,14-epoxymorphinan derivative and its pharmacology.EBI Kitasato University
18337104 7 Syntheses of 4,6'-epoxymorphinan derivatives and their pharmacologies.EBI Kitasato University
18370374 12 Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility.EBI Vrije Universiteit Brussel
18311909 10 Synthesis of a potent and selective (18)F-labeled delta-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for positron emission tomography imaging.EBI Stanford University School of Medicine
18178091 24 Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502).EBI University of Ferrara
18166466 12 Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors.EBI Harvard Medical School
17981041 79 Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers.EBI McLean Hospital
18293909 5 Toward a structure-based model of salvinorin A recognition of the kappa-opioid receptor.EBI University of Minnesota
17402725 9 Indium-labeled macrocyclic conjugates of naltrindole: high-affinity radioligands for in vivo studies of peripheral delta opioid receptors.EBI University of Missouri-Columbia
16942034 19 Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.EBI University of Cagliari
16789756 25 New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands.EBI Vrije Universiteit Brussels
16509592 101 Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists.EBI University of Arizona
15857143 48 Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities.EBI University La Sapienza
15863299 8 Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers.EBI University of Arizona
14998329 142 Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].EBI Southern Research Institute
13678399 54 Peptide science: exploring the use of chemical principles and interdisciplinary collaboration for understanding life processes.EBI University of Arizona
12459023 46 Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore.EBI University of Cagliari
11311071 53 Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy.EBI National Institute of Diabetes and Digestive and Kidney Diseases
11300867 32 Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the"address" recognition locus.EBI University of Minnesota
11543672 24 [2',6'-Dimethyltyrosine]dynorphin A(1-11)-NH2 analogues lacking an N-terminal amino group: potent and selective kappa opioid antagonists.EBI Clinical Research Institute of Montreal
11405645 13 Transformation of a kappa-opioid receptor antagonist to a kappa-agonist by transfer of a guanidinium group from the 5'- to 6'-position of naltrindole.EBI University of Minnesota
11052799 10 Synthesis and evaluation of N,N-dialkyl enkephalin-based affinity labels for delta opioid receptors.EBI University of Maryland
10639287 62 Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands.EBI National Institute of Diabetes and Digestive and Kidney Diseases
10479286 53 Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.EBI Southern Research Institute
9667975 86 Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.EBI Southern Research Institute
9057856 53 Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid rEBI National Institute of Diabetes and Digestive and Kidney Diseases
9397176 28 Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors.EBI University of Arizona
9379438 31 Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept.EBI SmithKline Beecham S.p.A.
9301674 60 Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity.EBI University of Ferrara
9207938 15 Pyrrolomorphinans as delta opioid receptor antagonists. The role of steric hindrance in conferring selectivity.EBI University of Minnesota
9171881 17 7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors.EBI University of Minnesota
8642567 64 Probes for narcotic receptor-mediated phenomena. 21. Novel derivatives of 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol- 6-yl)-phenols with improved delta opioid receptor selectivity.EBI National Institute of Diabetes and Digestive and Kidney Diseases
7739011 90 Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)morphans by application of the message-address concept: preparation of delta-opioid receptor ligands.EBI National Institute of Diabetes and Digestive and Kidney Diseases
8035418 30 Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist.EBI National Institute of Diabetes and Digestive and Kidney Diseases
8021929 13 Synthesis and delta-opioid receptor antagonist activity of a naltrindole analogue with a regioisomeric indole moiety.EBI University of Minnesota
8021915 16 Newly discovered stereochemical requirements in the side-chain conformation of delta opioid agonists for recognizing opioid delta receptors.EBI University of Arizona
8201592 27 [L-Ala3]DPDPE: a new enkephalin analog with a unique opioid receptor activity profile. Further evidence of delta-opioid receptor multiplicity.EBI University of Arizona
8289188 30 Cyclic enkephalin analogs with exceptional potency at peripheral delta opioid receptors.EBI University of Arizona
8360887 9 Synthesis and kappa-opioid antagonist selectivity of a norbinaltorphimine congener. Identification of the address moiety required for kappa-antagonist activity.EBI University of Minnesota
1648137 30 Topographically designed analogues of [D-Pen,D-Pen5]enkephalin.EBI University of Arizona
1851843 96 Synthesis and structure-activity relationships of deltorphin analogues.EBI University of Ferrara
2832604 3 Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity.EBI University of Minnesota
6296388 68 Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity.EBI TBA
6276540 20 Evidence of the preferential involvement of mu receptors in analgesia using enkephalins highly selective for peripheral mu or delta receptors.EBI TBA
15115401 26 Oral bioavailability of a new class of micro-opioid receptor agonists containing 3,6-bis[Dmt-NH(CH(2))(n)]-2(1H)-pyrazinone with central-mediated analgesia.EBI National Institutes of Environmental Health Sciences
11755357 14 Synthesis and biological activities of YkFA analogues: effects of position 4 substitutions and altered ring size on in vitro opioid activity.EBI University of Louisville
10612597 31 Optically pure (-)-4-[(N-allyl-3-methyl-4-piperidinyl)phenyl-amino]-N,N-diethylbenzami de displays selective binding and full agonist activity for the delta opioid receptor.EBI Research Triangle Institute
10571174 25 (+/-)-4-[(N-allyl-cis-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide displays selective binding for the delta opioid receptor.EBI Research Triangle Institute
 33 Pyrrolooctahydroisoquinolines as potent and selective opioid receptor ligands: SAR analysis and docking studiesEBI TBA
22197670 51 Synthesis of quinolinomorphinan-4-ol derivatives asd opioid receptor agonists.EBI Kitasato University
21925887 10 Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands.EBI University of Arizona
21889335 27 Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. Part 2: Synthesis of novel triplet drugs with the epoxymethano structure (capped homotriplet).EBI Kitasato University
21413804 21 Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist.EBI Vrije Universiteit Brussel
21366266 66 Discovery of a potent and efficacious peptide derivative ford/µ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.EBI University of Arizona
20850307 27 Design and synthesis of KNT-127, ad-opioid receptor agonist effective by systemic administration.EBI Kitasato University
20692738 34 Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2.EBI "Sapienza" Università di Roma
20637637 46 Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds.EBI University of Cagliari
20617791 70 Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines.EBI University of Arizona
20476738 14 Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-alpha,beta-didehydrophenylalanine (Delta(Z)Phe) residues.EBI Universit£ di Roma
20137938 28 Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds.EBI Vrije Universiteit Brussel
19762245 69 The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.EBI University of Arizona
19646882 72 Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways.EBI University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and the Informatics Institute of UMDNJ
19540763 4 Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain.EBI University of Arizona
19827750 39 Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1).EBI Clinical Research Institute of Montreal
19807094 45 The effects of C-terminal modifications on the opioid activity of [N-benzylTyr(1)]dynorphin A-(1-11) analogues.EBI University of Kansas
19715279 20 Design, synthesis, and pharmacological activities of dynorphin A analogues cyclized by ring-closing metathesis.EBI The University of Kansas
19642675 60 Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore.EBI University of Cagliari
19560919 28 Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue.EBI Universit£ di Roma
 12 The stereochemical requirements of the novel δ-opioid selective dipeptide antagonist TMT-TicEBI TBA
 8 Topographical requirements for delta opioid ligands: The synthesis and biological properties of a cyclic analogue of deltorphin IEBI TBA
19147366 60 Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor.EBI McLean Hospital
19062273 41 Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold.EBI Vrije Universiteit Brussel
18821747 45 The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.EBI University of Arizona
18800771 26 Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp].EBI National University of Singapore
18701308 1 Design and synthesis of a metabolically stable and potent antitussive agent, a novel delta opioid receptor antagonist, TRK-851.EBI Toray Industries, Inc.
18680274 44 Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic.EBI University of Cagliari
18490168 32 Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling.EBI Lanzhou University
17826995 48 Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform.EBI Kobe Gakuin University
17497839 72 Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.EBI Kobe Gakuin University
17350835 88 Further studies of tyrosine surrogates in opioid receptor peptide ligands.EBI Adolor Corporation
17315860 40 Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity.EBI Clinical Research Institute of Montreal
17266203 29 Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D-2-Nal(4)]endomorphin-2 (Antanal-2).EBI Medical University
17201419 93 Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors.EBI University of Arizona
17188879 16 Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: design, synthesis, and pharmacological characterization.EBI Lanzhou University
17142049 40 Transformation of mu-opioid receptor agonists into biologically potent mu-opioid receptor antagonists.EBI Kobe Gakuin University
16949282 12 Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity.EBI Kobe Gakuin University
16828552 20 Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity.EBI University of Arizona
16759107 18 6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides.EBI Universidad de Santiago de Compostela
16483774 66 Identification of potent phenyl imidazoles as opioid receptor agonists.EBI Johnson & Johnson Pharmaceutical Research & Development
16366592 33 Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).EBI University of Cagliari
16335927 48 Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists.EBI Kobe Gakuin University
16275086 18 Synthesis and biological activity of the first cyclic biphalin analogues.EBI University of Arizona
16183273 12 New series of potent delta-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif.EBI Kobe Gakuin University
16107162 10 From the potent and selective mu opioid receptor agonist H-Dmt-d-Arg-Phe-Lys-NH(2) to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH.EBI University of Cagliari
15780619 15 Structure-activity relationship of the novel bivalent and C-terminal modified analogues of endomorphin-2.EBI Lanzhou University
15658871 28 Development of potent mu-opioid receptor ligands using unique tyrosine analogues of endomorphin-2.EBI Kobe Gakuin University
15324897 3 A novel cyclic enkephalin analogue with potent opioid antagonist activity.EBI Clinical Research Institute of Montreal
14711314 63 Synthesis and opioid activity of side-chain-to-side-chain cyclic dynorphin A-(1-11) amide analogues cyclized between positions 2 and 5. 1. Substitutions in position 3.EBI University of Maryland
12954053 39 Effects of the substitution of Phe4 in the opioid peptide [D-Ala8]dynorphin A-(1-11)NH2.EBI University of Maryland
12852751 34 Unique high-affinity synthetic mu-opioid receptor agonists with central- and systemic-mediated analgesia.EBI Kobe Gakuin University
12657261 32 Dermorphin tetrapeptide analogues with 2',6'-dimethylphenylalanine (Dmp) substituted for aromatic amino acids have high mu opioid receptor binding and biological activities.EBI Tohoku Pharmaceutical University
12408719 21 Synthesis and structure-activity relationships of an orally available and long-acting analgesic peptide, N(alpha)-amidino-Tyr-D-Arg-Phe-MebetaAla-OH (ADAMB).EBI Daiichi Fine Chemical Co. Ltd.
12190304 10 Solid phase synthesis and evaluation of Tyr-Tic-Phe-Phe(p-NHCOCH(2)Br) ([Phe(p-bromoacetamide)(4)]TIPP), a potent affinity label for delta opioid receptors.EBI University of Maryland
12166947 30 Synthesis and biological activities of cyclic lanthionine enkephalin analogues: delta-opioid receptor selective ligands.EBI University of California
11958984 24 Dermorphin and deltorphin heptapeptide analogues: replacement of Phe residue by Dmp greatly improves opioid receptor affinity and selectivity.EBI Tohoku Pharmaceutical University
11212102 26 Enkephalin analogues with 2',6'-dimethylphenylalanine replacing phenylalanine in position 4.EBI Tohoku Pharmaceutical University
11150176 9 Synthesis and evaluation of isothiocyanate-containing derivatives of the delta-opioid receptor antagonist Tyr-Tic-Phe-Phe (TIPP) as potential affinity labels for delta-opioid receptors.EBI University of Maryland
11150174 84 Synthesis and in vitro and in vivo activity of (-)-(1R,5R,9R)- and (+)-(1S,5S,9S)-N-alkenyl-, -N-alkynyl-, and -N-cyanoalkyl-5, 9-dimethyl-2'-hydroxy-6,7-benzomorphan homologues.EBI Virginia Commonwealth University
10753473 14 Deltorphin II analogues with 6-hydroxy-2-aminotetralin-2-carboxylic acid in position 1.EBI Hungarian Academy of Sciences
10617088 15 Synthesis and biological activities of position one and three transposed analogs of the opioid peptide YKFA.EBI University of Louisville
9986710 28 Dermorphin and deltorphin glycosylated analogues: synthesis and antinociceptive activity after systemic administration.EBI University "La Sapienza" of Rome
9871617 24 Modifications of the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide.EBI University of Arizona
9822547 41 De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor.EBI The University of Arizona
9301669 24 7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands.EBI University of Minnesota
9258365 28 Helix-inducing alpha-aminoisobutyric acid in opioid mimetic deltorphin C analogues.EBI National Institute of Environmental Health Sciences
8691442 52 Effects of modifications of residues in position 3 of dynorphin A(1-11)-NH2 on kappa receptor selectivity and potency.EBI University of Arizona
8576920 34 Design and synthesis of 1-aminocycloalkane-1-carboxylic acid-substituted deltorphin analogues: unique delta and mu opioid activity in modified peptides.EBI University of Ferrara
8384662 20 A topochemical approach to explain morphiceptin bioactivity.EBI University of California
8289187 47 Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors.EBI University of Arizona
8096246 70 Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs.EBI University of Arizona
8057274 18 Discovery of a potent, peripherally selective trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonist for the treatment of gastrointestinal motility disorders.EBI Lilly Research Laboratories
7996550 12 Development of a model for the delta opioid receptor pharmacophore. 2. Conformationally restricted Phe3 replacements in the cyclic delta receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13).EBI University of Michigan
7996549 40 Development of a model for the delta opioid receptor pharmacophore. 1. Conformationally restricted Tyr1 replacements in the cyclic delta receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13).EBI University of Michigan
7932577 24 Selective kappa-opioid agonists: synthesis and structure-activity relationships of piperidines incorporating on oxo-containing acyl group.EBI SmithKline Beecham Farmaceutici S.p.A.
7658453 16 Stereoisomers of N-[1-hydroxy-(2-phenylethyl)-3-methyl-4-piperidyl]- N-phenylpropanamide: synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics.EBI Institute of Materia Medica
2822930 48 Structure-activity relationships of cyclic opioid peptide analogues containing a phenylalanine residue in the 3-position.EBI Clinical Research Institute of Montreal
1967312 91 Synthesis and structure-activity relationships of dynorphin A-(1-8) amide analogues.EBI Eisai Co., Ltd.
1331451 64 Conformationally restricted deltorphin analogues.EBI Clinical Research Institute of Montreal
1320122 54 Ring substituted and other conformationally constrained tyrosine analogues of [D-Pen2,D-Pen5]enkephalin with delta opioid receptor selectivity.EBI University of Arizona
15383632 15 Comparison of pharmacological activities of three distinct kappa ligands (Salvinorin A, TRK-820 and 3FLB) on kappa opioid receptors in vitro and their antipruritic and antinociceptive activities in vivo.BDB Temple University
11270320 11 Dynorphin A analogs containing a conformationally constrained phenylalanine derivative in position 4: reversal of preferred stereochemistry for opioid receptor affinity and discrimination of kappa vs. delta receptors.BDB University of Maryland
11121615 32 Synthesis and in vitro opioid activity profiles of DALDA analogues.BDB Clinical Research Institute of Montreal
10565829 17 Ring-constrained orvinols as analogs of buprenorphine: differences in opioid activity related to configuration of C(20) hydroxyl group.BDB Loughborough University
8935801 586 Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding.BDB Janssen Research Foundation
6248635 48 Opioid binding properties of brain and peripheral tissues: evidence for heterogeneity in opioid ligand binding sites.BDB Stanford University