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51 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27865702 2 Biosynthetic approaches to creating bioactive fungal metabolites: Pathway engineering and activation of secondary metabolism.EBI RIKEN CSRS
27793568 2 Functional 1,3a,6a-triazapentalene scaffold: Design of fluorescent probes for kinesin spindle protein (KSP).EBI University of Shizuoka
26396688 26 Structure-Guided Design of Novel l-Cysteine Derivatives as Potent KSP Inhibitors.EBI University of Shizuoka
25868746 27 Discovery of novel spiro 1,3,4-thiadiazolines as potent, orally bioavailable and brain penetrant KSP inhibitors.EBI Merck Research Laboratories
25001485 8 Synthetic studies on mitotic kinesin Eg5 inhibitors: synthesis and structure-activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives.EBI Kyowa Hakko Kirin Co., Ltd
25453799 1 Design, synthesis and anticancer evaluation of tetrahydro--carboline-hydantoin hybrids.EBI TBA
24794744 54 Optimization of diaryl amine derivatives as kinesin spindle protein inhibitors.EBI Kyoto University
24184776 19 Synthesis, biological evaluation and molecular docking studies of flavone and isoflavone derivatives as a novel class of KSP (kinesin spindle protein) inhibitors.EBI Nanjing University
23899248 1 Resistance by allostery: a novel perspective for eg5-targeted drug design.EBI Korea Institute of Science and Technology
23875972 3 Mitotic kinesin Eg5 overcomes inhibition to the phase I/II clinical candidate SB743921 by an allosteric resistance mechanism.EBI The Beatson Institute for Cancer Research
23434636 25 Advances in the discovery of kinesin spindle protein (Eg5) inhibitors as antitumor agents.EBI Cairo University
23394180 68 Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.EBI The Beatson Institute for Cancer Research
23287057 1 Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent.EBI CSIR-Central Drug Research Institute
22749640 36 Doing the methylene shuffle--further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine.EBI University of Strathclyde
22309208 8 Receptor-ligand interaction-based virtual screening for novel Eg5/kinesin spindle protein inhibitors.EBI Korea Institute of Science and Technology
22248262 101 Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity.EBI The Beatson Institute for Cancer Research
20149654 66 The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5.EBI Merck Serono
17095225 40 Pharmacophore identification of KSP inhibitors.EBI China Pharmaceutical University
16730979 16 Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
21620536 1 Recent progress in biological activities of synthesized phenothiazines.EBI The Medical University of Silesia
21899292 76 Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent.EBI AstraZeneca
21856161 34 De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors.EBI China Pharmaceutical University
21855351 14 Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity.EBI New Mexico State University
21620531 1 Synthesis and biological evaluation of conformationally flexible as well as restricted dimers of monastrol and related dihydropyrimidones.EBI Indian Institute of Chemical Technology
21599002 19 Structure-activity relationships of carboline and carbazole derivatives as a novel class of ATP-competitive kinesin spindle protein inhibitors.EBI Kyoto University
21344920 36 Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5.EBI Institute for Cancer Research
20934346 46 Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents.EBI China Pharmaceutical University
20597485 3 Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol.EBI Institute for Cancer Research
20521839 28 Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds.EBI Kyoto University
20537544 30 Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP.EBI China Pharmaceutical University
19945875 31 The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5.EBI Novartis Institutes for Biomedical Research
19481450 121 Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors.EBI Schering-Plough Research Institute
19167222 26 Bis(hetero)aryl derivatives as unique kinesin spindle protein inhibitors.EBI University of Shizuoka
17251189 4 Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration.EBI CNRS-Commissariat à l'Energie Atomique-Université Joseph Fourier
17804233 29 Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP.EBI Merck Research Laboratories
17761419 16 Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP.EBI Merck Research Laboratories
17725339 61 Novel ATP-competitive kinesin spindle protein inhibitors.EBI GlaxoSmithKline
17587586 31 New chemical tools for investigating human mitotic kinesin Eg5.EBI CNRS-Université Louis Pasteur
17524640 21 Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors.EBI University of Shizuoka
17395460 13 Kinesin spindle protein (KSP) inhibitors. Part V: discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by beta-fluorination to overcome cellular efflux by P-glycoprotein.EBI Merck Research Laboratories
16884297 2 Inhibition of kinesin motor proteins by adociasulfate-2.EBI University of Georgia
16439122 16 Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility.EBI Merck Research Laboratories
15808464 32 Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP.EBI Merck Research Laboratories
20718440 7 Novel benzimidazole inhibitors bind to a unique site in the kinesin spindle protein motor domain.BDB Merck Research Laboratories
16216042 10 Synthesis and biological evaluation of novel EG5 inhibitors.BDB University of Leipzig
17922005 27 ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.BDB GlaxoSmithKline
17498954 33 Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors.BDB Kalypsys, Inc.
16458511 44 Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series.BDB Bristol-Myers Squibb Company
18266314 65 Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.BDB Institut de Biologie Structurale