BindingDB logo
myBDB logout

115 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27676469 64 Phenyltetrazolyl-phenylamides: Substituent impact on modulation capability and selectivity toward the efflux protein ABCG2 and investigation of interaction with the transporter.EBI Rheinische Friedrich-Wilhelms-Universit£t Bonn
27504669 39 Hernandezine, a Bisbenzylisoquinoline Alkaloid with Selective Inhibitory Activity against Multidrug-Resistance-Linked ATP-Binding Cassette Drug Transporter ABCB1.EBI Chang Gung Memorial Hospital
27131064 22 Synthesis and bioevaluation of novel benzodipyranone derivatives as P-glycoprotein inhibitors for multidrug resistance reversal agents.EBI China Medical University
27262425 14 Structure-activity relationships of dibenzoylhydrazines for the inhibition of P-glycoprotein-mediated quinidine transport.EBI Kyoto University
27100033 40 The combination of quinazoline and chalcone moieties leads to novel potent heterodimeric modulators of breast cancer resistance protein (BCRP/ABCG2).EBI University of Bonn
26836364 30 Optimization by Molecular Fine Tuning of Dihydro-▀-agarofuran Sesquiterpenoids as Reversers of P-Glycoprotein-Mediated Multidrug Resistance.EBI Instituto Universitario de Bio-Org£nica"Antonio Gonz£lez"
26774038 67 Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization.EBI University of Regensburg
26123642 38 The interaction of 4-thiazolidinone derivatives containing indolin-2-one moiety with P-glycoprotein studied using K562 cell lines.EBI The First Affiliated Hospital of Dalian Medical University
26233798 11 Optimization of permethyl ningalin B analogs as P-glycoprotein inhibitors.EBI Ocean University of China
26048803 3 Discovery of substituted 1,4-dihydroquinolines as novel promising class of P-glycoprotein inhibitors: First structure-activity relationships and bioanalytical studies.EBI Martin Luther University Halle-Wittenberg
25985195 94 Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives.EBI The Hong Kong Polytechnic University
25695368 4 Restoration of Chemosensitivity in P-Glycoprotein-Dependent Multidrug-Resistant Cells by Dihydro-▀-agarofuran Sesquiterpenes from Celastrus vulcanicola.EBI Instituto Universitario de Bio-Org£nica Antonio Gonz£lez
23132334 28 In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor.EBI GlaxoSmithKline
25855895 23 HM30181 Derivatives as Novel Potent and Selective Inhibitors of the Breast Cancer Resistance Protein (BCRP/ABCG2).EBI University of Bonn
25093931 44 Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding.EBI Universit£ di Bari"Aldo Moro"
25499431 4 Investigating the binding interactions of the anti-Alzheimer's drug donepezil with CYP3A4 and P-glycoprotein.EBI University of Waterloo
25462276 39 Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity froms2 receptor affinity in mixed P-gp/s2 receptor agents.EBI Universit£ degli Studi di Bari Aldo Moro
25379609 24 SAR studies on tetrahydroisoquinoline derivatives: the role of flexibility and bioisosterism to raise potency and selectivity toward P-glycoprotein.EBI Universit£ degli Studi di Bari"A. Moro"
25310383 50 Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.EBI Novartis Institutes for Biomedical Research
24952376 2 4,5-Di-substituted benzyl-imidazol-2-substituted amines as the structure template for the design and synthesis of reversal agents against P-gp-mediated multidrug resistance breast cancer cells.EBI Ocean University of China
24773054 11 Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid.EBI St. John's University
24613626 21 Synthesis, biological evaluation and 3D-QSAR studies of new chalcone derivatives as inhibitors of human P-glycoprotein.EBI Medical University Vienna
24607999 16 SAR study on arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity.EBI Universit£ di Pisa
24184213 71 Investigation of quinazolines as inhibitors of breast cancer resistance protein (ABCG2).EBI University of Bonn
24161678 9 Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging ofs2 receptors.EBI Universit£ degli Studi di Bari ALDO MORO
23332369 5 Synthesis of N(4)-(substituted phenyl)-N(4)-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells.EBI Duquesne University
23374872 27 Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp.EBI Universit£ degli Studi di Bari 'A. Moro'
23347803 29 Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters.EBI Universit£ degli Studi di Bari ALDO MORO
21723648 41 Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of p-glycoprotein targeting the nucleotide binding domain.EBI Chosun University
15331656 2 Intrinsic and acquired forms of resistance against the anticancer ruthenium compound KP1019 [indazolium trans-[tetrachlorobis(1H-indazole)ruthenate (III)] (FFC14A).EBI Institute of Cancer Research
15359574 1 Transport characteristics of fexofenadine in the Caco-2 cell model.EBI Uppsala University
9914792 3 Inhibitory effects of a cyclosporin derivative, SDZ PSC 833, on transport of doxorubicin and vinblastine via human P-glycoprotein.EBI Kobe University
11145223 7 Inhibitory potencies of 1,4-dihydropyridine calcium antagonists to P-glycoprotein-mediated transport: comparison with the effects on CYP3A4.EBI Kanazawa University
11231118 8 Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport.EBI Kanazawa University
7562598 1 Cepharanthin, a multidrug resistant modifier, is a substrate for P-glycoprotein.EBI Kyoto University Hospital
8862725 8 Ranking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay.EBI Strasbourg 1 University
12134945 9 Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?EBI The University of Kansas
11474784 6 HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein.EBI Schering-Plough Research Institute
11743742 6 Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4.EBI Schering-Plough Research Institute
11606389 1 The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein.EBI Schering-Plough Research Institute
11027568 1 Cholesterol interaction with the daunorubicin binding site of P-glycoprotein.EBI Schering-Plough Research Institute
11452702 1 P-glycoprotein interactions of nefazodone and trazodone in cell culture.EBI Tufts University School of Medicine
11408360 1 Methadone inhibits rhodamine123 transport in Caco-2 cells.EBI Tufts University School of Medicine
11454724 3 Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein.EBI Schering-Plough Research Institute
11716514 103 Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors.EBI Schering-Plough Research Institute
11751127 2 Interaction of common azole antifungals with P glycoprotein.EBI Schering-Plough Research Institute
10820137 13 Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes.EBI Vanderbilt University School of Medicine
12700464 1 Lopinavir: acute exposure inhibits P-glycoprotein; extended exposure induces P-glycoprotein.EBI Tufts University School of Medicine
10901697 1 Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both P-glycoprotein and CYP3A in vitro.EBI Vanderbilt University School of Medicine
11964599 4 Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein.EBI Vanderbilt University
11770010 3 Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein.EBI Institute of Clinical Pharmacology
10773005 2 Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein.EBI Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
10729360 1 Inhibition of the P-glycoprotein- and multidrug resistance protein-mediated efflux of anthracyclines and calceinacetoxymethyl ester by PAK-104P.EBI Universit£ Paris Nord
15240100 12 Reversal of P-glycoprotein-mediated MDR by 5,7,3',4',5'-pentamethoxyflavone and SAR.EBI Chosun University
15616150 14 Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1.EBI Pfizer Inc.
12569305 12 Differential effects of the optical isomers of KR30031 on cardiotoxicity and on multidrug resistance reversal activity.EBI Korea Research Institute of Chemical Technology
14755051 1 Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine.EBI Washington University School of Medicine
10411602 2 Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities.EBI Lilly Research Laboratories
17890094 35 New functional assay of P-glycoprotein activity using Hoechst 33342.EBI University of Bonn
16722621 3 New potent P-glycoprotein inhibitors carrying a polycyclic scaffold.EBI University of Bologna
15481991 2 Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring.EBI Yale University
11784143 4 C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump.EBI Georgetown University School of Medicine
10386932 55 Synthesis and evaluation of hapalosin and analogs as MDR-reversing agents.EBI Eisai Research Institute
22727780 17 Thiorhodamines containing amide and thioamide functionality as inhibitors of the ATP-binding cassette drug transporter P-glycoprotein (ABCB1).EBI The State University of New York
22541068 73 Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.EBI Uppsala University
12604693 1 Pharmacokinetics and interactions of a novel antagonist of chemokine receptor 5 (CCR5) with ritonavir in rats and monkeys: role of CYP3A and P-glycoprotein.EBI Merck Research Laboratories
11961113 36 Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.EBI Lilly Research Laboratories
9751076 2 Effect of modulators on the ATPase activity and vanadate nucleotide trapping of human P-glycoprotein.EBI Lilly Research Laboratories
12130727 2 Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4.EBI Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
10198227 3 PSC833, cyclosporin A, and dexniguldipine effects on cellular calcein retention and inhibition of the multidrug resistance pump in human leukemic lymphoblasts.EBI University of Tennessee Medical Center
19721074 1 Nonclinical pharmacokinetics of oseltamivir and oseltamivir carboxylate in the central nervous system.EBI F. Hoffmann-La Roche Ltd.
17664327 10 Effects of human immunodeficiency virus protease inhibitors on the intestinal absorption of tenofovir disoproxil fumarate in vitro.EBI Gilead Sciences Inc
19170519 34 Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar.EBI University of Regensburg
18083034 70 Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors.EBI University of Bonn
17936633 16 Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives.EBI Universit£ degli Studi di Bari
18257545 34 Synthesis and biological evaluation of (hetero)arylmethyloxy- and arylmethylamine-phenyl derivatives as potent P-glycoprotein modulating agents.EBI Universita degli Studi di Bari
17352460 159 Self-organizing maps for identification of new inhibitors of P-glycoprotein.EBI University of Vienna
16686543 44 Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells.EBI Universit£ di Bologna
12699389 152 Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery.EBI F. Hoffmann-LaRoche Ltd.
12477351 41 Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).EBI Bulgarian Academy of Sciences
12361387 59 Cyclosporins: structure-activity relationships for the inhibition of the human MDR1 P-glycoprotein ABC transporter.EBI Strasbourg 1 University
10891114 28 Aureobasidins: structure-activity relationships for the inhibition of the human MDR1 P-glycoprotein ABC-transporter.EBI Strasbourg 1 University
9767638 24 Substituted 4-acylpyrazoles and 4-acylpyrazolones: synthesis and multidrug resistance-modulating activity.EBI University of Vienna
10673101 10 The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoprotein.EBI Universit£ Claude Bernard-Lyon 1
22112208 98 Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein.EBI Universit£ degli Studi di Bari"Aldo Moro"
21856049 8 Overcoming human P-glycoprotein-dependent multidrug resistance with novel dihydro-ß-agarofuran sesquiterpenes.EBI Instituto Universitario de Bio-Org£nica Antonio Gonz£lez
21570282 28 Solid phase synthesis of tariquidar-related modulators of ABC transporters preferring breast cancer resistance protein (ABCG2).EBI Universidad Nacional de Colombia
21341745 4 A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields.EBI University of Perugia
21189339 5 Interaction potential of etravirine with drug transporters assessed in vitro.EBI University Hospital Heidelberg
21354800 77 Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).EBI University of Bonn
20731360 6 Potent and fully noncompetitive peptidomimetic inhibitor of multidrug resistance P-glycoprotein.EBI UMR 5086 CNRS
20684594 71 Phenylsulfonylfuroxans as modulators of multidrug-resistance-associated protein-1 and P-glycoprotein.EBI Universita degli Studi di Torino
19819706 16 Antimalarial and antitrypanosomal activity of a series of amide and sulfonamide derivatives of a 2,5-diaminobenzophenone.EBI Philipps-Universit£t Marburg
19402665 29 Rhodamine inhibitors of P-glycoprotein: an amide/thioamide"switch" for ATPase activity.EBI The State University of New York
19053888 114 2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties.EBI Universita degli Studi di Bari
18954040 5 Bis-pyranobenzoquinones as a new family of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in mammalian cells and the protozoan parasite Leishmania.EBI Instituto Universitario de Bio-Orgánica Antonio González
18524592 4 Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum.EBI Università degli Studi di Bari
17850057 72 Biological evaluation, structure-activity relationships, and three-dimensional quantitative structure-activity relationship studies of dihydro-beta-agarofuran sesquiterpenes as modulators of P-glycoprotein-dependent multidrug resistance.EBI Instituto Universitario de Bio-OrgAnica Antonio GonzAlez
17399990 45 In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity on CYP-450 (Part 2).EBI Université Laval
17064079 22 Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition.EBI Università degli Studi di Bari
16640345 9 Biological evaluation of bishydroxymethyl-substituted cage dimeric 1,4-dihydropyridines as a novel class of p-glycoprotein modulating agents in cancer cells.EBI Martin-Luther-University Halle-Wittenberg
16458504 37 Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand.EBI Columbia University College of Physicians and Surgeons
16392798 46 Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.EBI Columbia University College of Physicians and Surgeons
14998324 190 Design and synthesis of new templates derived from pyrrolopyrimidine as selective multidrug-resistance-associated protein inhibitors in multidrug resistance.EBI Xenova Ltd.
11958985 21 Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1).EBI Eli Lilly and Company
11140738 8 B-ring substituted 5,7-dihydroxyflavonols with high-affinity binding to P-glycoprotein responsible for cell multidrug resistance.EBI Département de Pharmacochimie Moléculaire UMR-CNRS 5063
27331911 27 Design, synthesis, biological evaluation, NMR and DFT studies of structurally simplified trimethoxy benzamides as selective P-glycoprotein inhibitors: the role of molecular flatness.BDB UniversitÓ di Bari Aldo Moro
16352709 44 Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis.BDB McGill University