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36 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
26713103 7 Potent Triazole Bisphosphonate Inhibitor of Geranylgeranyl Diphosphate Synthase.EBI University of Iowa
25815158 6 Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries.EBI University of Illinois at Urbana-Champaign
25935643 5 N-Oxide derivatives of 3-(3-pyridyl)-2-phosphonopropanoic acids as potential inhibitors of Rab geranylgeranylation.EBI University of Iowa
25630225 5 Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase.EBI McGill University
24811300 20 Biased and unbiased strategies to identify biologically active small molecules.EBI Institut de Chimie des Substances Naturelles
25184810 4 Structural evidence of N6-isopentenyladenosine as a new ligand of farnesyl pyrophosphate synthase.EBI Universit£ degli Studi di Salerno
24911527 30 Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases.EBI McGill University
24726306 11 Geranyl and neryl triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase.EBI University of Iowa
23998921 19 Thienopyrimidine bisphosphonate (ThPBP) inhibitors of the human farnesyl pyrophosphate synthase: optimization and characterization of the mode of inhibition.EBI McGill University
23477945 3 Discovery of thienopyrimidine-based inhibitors of the human farnesyl pyrophosphate synthase--parallel synthesis of analogs via a trimethylsilyl ylidene intermediate.EBI McGill University
12825934 55 A quantitative structure-activity relationship and pharmacophore modeling investigation of aryl-X and heterocyclic bisphosphonates as bone resorption agents.EBI University of Illinois at Urbana-Champaign
22884353 15 Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site 'capping' phenyls.EBI McGill University
21780776 40 Remarkable potential of thea-aminophosphonate/phosphinate structural motif in medicinal chemistry.EBI Wroclaw University of Technology
22390415 28 Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells.EBI McGill University
20394422 6 Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid.EBI University of Southern California
18434151 2 Farnesyl pyrophosphate synthase enantiospecificity with a chiral risedronate analog, [6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl(hydroxy)methylene]bis(phosphonic acid) (NE-10501): Synthetic, structural, and modeling studies.EBI University of Southern California
18308574 15 Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation.EBI University of Iowa
18327899 106 Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.EBI University of Oxford
18295483 50 Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones.EBI Novartis Institutes for BioMedical Research
20801032 3 Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase.EBI McGill University
20303767 5 Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi.EBI University of California Santa Cruz
18937434 7 Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism.EBI Universita di Ferrara
18789701 2 Bisphosphonate inhibitors of ATP-mediated HIV-1 reverse transcriptase catalyzed excision of chain-terminating 3'-azido, 3'-deoxythymidine: a QSAR investigation.EBI University of Illinois at Urbana-Champaign
17975902 8 Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate.EBI University of Southern California
17963374 11 Activity of sulfonium bisphosphonates on tumor cell lines.EBI University of Illinois at Urbana-Champaign
16143525 8 Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase.EBI Universidad de Buenos Aires
14613320 186 3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates.EBI University of Illinois at Urbana-Champaign
12951099 28 Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase.EBI Universidad de Buenos Aires
12014956 34 Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents.EBI University of Illinois at Urbana-Champaign
27428767 6 Fluorescent Farnesyl Diphosphate Analogue: A Probe To Validate trans-Prenyltransferase Inhibitors.BDB Academia Sinica
23421555 11 Farnesyl diphosphate synthase inhibitors from in silico screening.BDB University of California San Diego
1567835 4 Steady-state kinetic mechanism of Ras farnesyl:protein transferase.BDB Merck Research Laboratories
20711197 12 Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery.BDB Novartis Institutes for Biomedical Research