BindingDB logo
myBDB logout

78 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27595421 21 The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists.EBI Janssen Pharmaceutical Research& Development L.L.C.
27548392 76 Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor.EBI Janssen Pharmaceutical Research& Development, LLC
27096039 20 Promising Therapeutic Potential of P2X7 Modulators.EBI Therachem Research Medilab (India) Pvt. Ltd.
26707399 45 Preclinical characterization of substituted 6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one P2X7 receptor antagonists.EBI Janssen Pharmaceutical Research& Development L.L.C.
26099534 72 Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists.EBI Janssen Pharmaceutical Research& Development L.L.C.
26099538 8 Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human.EBI University of Leeds
25597334 67 Discovery of novel 2,5-dioxoimidazolidine-based P2X(7) receptor antagonists as constrained analogues of KN62.EBI Gwangju Institute of Science and Technology (GIST)
24411477 84 Carbamazepine derivatives with P2X4 receptor-blocking activity.EBI University of Bonn
24246730 34 Design and synthesis of potent and selective P2X3 receptor antagonists derived from PPADS as potential pain modulators.EBI Gwangju Institute of Science and Technology (GIST)
23510563 9 Synthesis and structure-activity relationships of carboxylic acid derivatives of pyridoxal as P2X receptor antagonists.EBI Gwangju Institute of Science and Technology
23121096 86 Ion channels as therapeutic targets: a drug discovery perspective.EBI Pfizer Inc.
17482819 36 Novel and potent 3-(2,3-dichlorophenyl)-4-(benzyl)-4H-1,2,4-triazole P2X7 antagonists.EBI Abbott Laboratories
21536435 90 Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine P2X(7) antagonists.EBI Abbott Laboratories
20934331 23 Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X(7) receptor.EBI GlaxoSmithKline
20673717 30 Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor.EBI GlaxoSmithKline
20579878 26 Structure-activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X(7) receptor.EBI GlaxoSmithKline
20399651 34 Synthesis and structure-activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor.EBI GlaxoSmithKline
20045645 66 Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist.EBI Roche Palo Alto
19191585 143 Antagonists of the P2X(7) receptor. From lead identification to drug development.EBI AstraZeneca
19397270 122 Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain.EBI Abbott Laboratories
18438986 71 Structure-activity relationship studies on N'-aryl carbohydrazide P2X7 antagonists.EBI Abbott Laboratories
18272366 74 Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists.EBI Abbott Laboratories
16759108 40 Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists.EBI Abbott Laboratories
14592504 19 Novel P2X7 receptor antagonists.EBI AstraZeneca
23075067 98 N-substituted phenoxazine and acridone derivatives: structure-activity relationships of potent P2X4 receptor antagonists.EBI University of Bonn
22400713 39 Structure-activity relationships and optimization of 3,5-dichloropyridine derivatives as novel P2X(7) receptor antagonists.EBI Gwangju Institute of Science and Technology (GIST)
21207957 163 Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor.EBI University of Bonn
18272365 57 Synthesis and in vitro activity of N'-cyano-4-(2-phenylacetyl)-N-o-tolylpiperazine-1-carboximidamide P2X7 antagonists.EBI Abbott Bioresearch Center
12213051 207 Purine and pyrimidine (P2) receptors as drug targets.EBI National Institute of Diabetes
14592505 31 Hit-to-Lead studies: the discovery of potent adamantane amide P2X7 receptor antagonists.EBI AstraZeneca R&D Charnwood
22078214 29 Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: part 2.EBI Merck Research Laboratories
21782426 42 Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X7 receptor.EBI Pfizer Inc.
21634377 73 Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.EBI Amgen Inc.
20634071 41 Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X(7) antagonists.EBI GlaxoSmithKline
21570840 44 Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: part 1.EBI Merck Research Laboratories
21565499 32 Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535.EBI Pfizer Inc.
20392639 18 Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist.EBI Pfizer St. Louis Research Laboratories
19800793 15 Synthesis and structure-activity relationships of pyrazolodiazepine derivatives as human P2X7 receptor antagonists.EBI Institute of Science& Technology
19540765 10 Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening.EBI University of Sydney
19231180 81 Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain.EBI Roche Palo Alto LLC
19231178 61 Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X(3)/P2X(2/3) antagonist for the treatment of pain.EBI Roche Palo Alto LLC
19110420 23 Synthesis and structure-activity relationships of novel, substituted 5,6-dihydrodibenzo[a,g]quinolizinium P2X7 antagonists.EBI Institute of Science and Technology (GIST)
18595695 43 Synthesis and activity of N-cyanoguanidine-piperazine P2X7 antagonists.EBI Abbott Bioresearch Center
18078749 22 Synthesis and structure-activity relationship studies of tyrosine-based antagonists at the human P2X7 receptor.EBI Institute of Science and Technology
17963373 36 Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors.EBI AstraZeneca R&D Charnwood
17585854 42 From tyrosine to glycine: synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor.EBI Università di Ferrara
15482953 2 Synthesis, radiolabeling, and preliminary biological evaluation of [3H]-1-[(S)-N,O-bis-(isoquinolinesulfonyl)-N-methyl-tyrosyl]-4-(o-tolyl)-piperazine, a potent antagonist radioligand for the P2X7 receptor.EBI Università di Ferrara
12672232 28 Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor.EBI Università di Ferrara
10762053 2 Synthesis of conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor.EBI Università di Ferrara
26123174 9 Discovery of novel purine-based heterocyclic P2X7 receptor antagonists.BDB Gwangju Institute of Science and Technology
11111828 16 Agonists and antagonists acting at P2X receptors: selectivity profiles and functional implications.BDB Biocentre Niederursel