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46 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
10821712 18 Quantized surface complementarity diversity (QSCD): a model based on small molecule-target complementarity.EBI NeoGenesis, Inc.
8759636 1 Structure-activity relationships of (E)-3-(1,4-benzoquinonyl)-2-[(3-pyridyl)-alkyl]-2-propenoic acid derivatives that inhibit both 5-lipoxygenase and thromboxane A2 synthetase.EBI Eisai Company Ltd.
8709092 21 Modulators of leukotriene biosynthesis and receptor activation.EBI Abbott Laboratories
7932529 37 Novel dual inhibitors of 5-lipoxygenase and thromboxane A2 synthetase: synthesis and structure-activity relationships of 3-pyridylmethyl-substituted 2-amino-6-hydroxybenzothiazole derivatives.EBI Eisai Company, Ltd.
8230121 15 Synthesis of structural analogs of leukotriene B4 and their receptor binding activity.EBI SmithKline Beecham Pharmaceuticals
 14 Synthesis and pharmacologic activity of hydroxyacetophenone-substituted benzophenone/xanthone leukotriene B4 receptor antagonistsEBI TBA
20380377 70 Discovery of novel and potent leukotriene B4 receptor antagonists. Part 1.EBI Roche Research Center
 15 N-aryl cinnamides: A novel class of rigid and highly potent leukotriene B4 receptor antagonistsEBI TBA
 1 3-Amino-1,2-benzisoxazoles: A new family of potent inhibitors of LTB4 binding to the human neutrophilsEBI TBA
 5 Synthesis and pharmacological profile of new 1,3-disubstituted cyclohexanes as leukotriene B4 receptor antagonistsEBI TBA
 25 Synthesis and in vitro profile of 7-substituted quinoline chromanols as novel, non-acidic LTB4 antagonistsEBI TBA
 16 2-alkyl-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol leukotriene B4 receptor antagonistsEBI TBA
 10 Synthesis and pharmacological activity of SC-53228, a leukotriene B4 receptor antagonist with high intrinsic potency and selectivityEBI TBA
 10 Structural analogues of LY292728, a highly potent xanthone dicarboxylic acid leukotriene B4 receptor antagonist: spatial positioning of the secondary acid groupEBI TBA
 12 Acid unit modifications of 1,2,4,5-substituted hydroxyacetophenones and the effect on in vitro and in vivo LTB4 receptor antagonismEBI TBA
 8 Ortho-alkoxyphenol leukotriene B4 receptor antagonists: effect of a chroman carboxylic acid.EBI TBA
 16 Ortho-alkoxyphenol leukotriene B4 receptor antagonistsEBI TBA
 1 Enantioselective total synthesis and pharmacologic profile of 12-deoxy-12(S)-methyl leukotriene B4EBI TBA
16190770 8 Synthesis of leukotriene B4 antagonists labeled with In-111 or Tc-99m to image infectious and inflammatory foci.EBI Bristol-Myers Squibb Medical Imaging
14643356 32 Structure-activity relationships of indole cytosolic phospholipase A(2)alpha inhibitors: substrate mimetics.EBI Wyeth Research
10782692 8 Leukotriene B4 photoaffinity probes: design, synthesis and evaluation of new arylazide-1,3-disubstituted cyclohexanes.EBI UPRESA-CNRS 5074
9888841 1 Carboxy-substituted cinnamides: a novel series of potent, orally active LTB4 receptor antagonists.EBI Novartis Pharmaceuticals Corporation
8809171 13 (E)-3-[6-[[(2,6-dichlorophenyl)thio]methyl]-3-(2-phenylethoxy)-2- pyridinyl]-2-propenoic acid: a high-affinity leukotriene B4 receptor antagonist with oral antiinflammatory activity.EBI SmithKline Beecham Pharmaceuticals
8809164 5 Structure-activity relationships study of two series of leukotriene B4 antagonists: novel indolyl and naphthyl compounds substituted with a 2-[methyl(2-phenethyl)amino]-2-oxoethyl side chain.EBI Rhône-Poulenc Rorer Central Research
8809163 3 A novel series of [2-[methyl(2-phenethyl)amino]-2-oxoethyl] benzene-containing leukotriene B4 antagonists: initial structure-activity relationships.EBI Rhone-Poulenc Rorer Central Research
8410983 7 (E)-3-[[[[6-(2-carboxyethenyl)-5-[[8-(4- methoxyphenyl)octyl]oxy]-2-pyridinyl]-methyl]thio]methyl]benzoic acid: a novel high-affinity leukotriene B4 receptor antagonist.EBI SmithKline Beecham Pharmaceuticals
8389876 11 Design, synthesis, and pharmacological evaluation of potent xanthone dicarboxylic acid leukotriene B4 receptor antagonists.EBI Lilly Research Laboratories
8254628 12 Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists.EBI Lilly Research Laboratories
8230123 7 Synthesis and LTB4 receptor antagonist activities of the naturally occurring LTB4 receptor antagonist Leucettamine A and related analogues.EBI Smithkline Beecham Pharmaceuticals
8230122 32 Trisubstituted pyridine leukotriene B4 receptor antagonists: synthesis and structure-activity relationships.EBI SmithKline Beecham Pharmaceuticals
8057289 17 Leukotriene B4 (LTB4) receptor antagonists: a series of (hydroxyphenyl)pyrazoles.EBI Lilly Research Laboratories
7932560 19 (E)-3-[[[[6-(2-carboxyethenyl)-5-[[8-(4- methoxyphenyl)octyl]oxy]-2-pyridinyl]-methyl]thio]methyl]benzoic acid and related compounds: high affinity leukotriene B4 receptor antagonists.EBI SmithKline Beecham Pharmaceuticals
7932545 3 (+)-1-(3S,4R)-[3-(4-phenylbenzyl)-4-hydroxychroman-7-yl]cyclopentane carboxylic acid, a highly potent, selective leukotriene B4 antagonist with oral activity in the murine collagen-induced arthritis model.EBI Pfizer Inc.
7699700 23 Second-generation leukotriene B4 receptor antagonists related to SC-41930: heterocyclic replacement of the methyl ketone pharmacophore.EBI Searle Research and Development
7473568 5 Synthetic and structure/activity studies on acid-substituted 2-arylphenols: discovery of 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- hydroxyphenoxy]-propoxy]phenoxy]benzoic acid, a high-affinity leukotriene B4 receptor antagonist.EBI Lilly Research Laboratories
2542550 1 7-[3-(4-acetyl-3-methoxy-2-propylphenoxy)propoxy]-3,4-dihydro-8- propyl-2H-1-benzopyran-2-carboxylic acid: an orally active selective leukotriene B4 receptor antagonist.EBI G.D. Searle and Co.
2170648 2 Benzophenone dicarboxylic acid antagonists of leukotriene B4. 2. Structure-activity relationships of the lipophilic side chain.EBI Lilly Research Laboratories
1333012 106 omega-[(4,6-Diphenyl-2-pyridyl)oxy]alkanoic acid derivatives: a new family of potent and orally active LTB4 antagonists.EBI Centre de Recherche de Vitry-Alfortville
1333011 29 omega-[(4-Phenyl-2-quinolyl)oxy]alkanoic acid derivatives: a new family of potent LTB4 antagonists.EBI Centre de Recherche de Vitry-Alfortville
1331462 9 4-[2-[Methyl(2-phenethyl)amino]-2-oxoethyl]-8-(phenylmethoxy)-2- naphthalenecarboxylic acid: a high affinity, competitive, orally active leukotriene B4 receptor antagonist.EBI Rhone-Poulenc Rorer Central Research
1324316 22 Omega-[(omega-arylalkyl)thienyl]alkanoic acids: from specific LTA4 hydrolase inhibitors to LTB4 receptor antagonists.EBI Centre de Recherche de Vitry-Alfortville
1313879 21 Development of 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase.EBI Merck Frosst Centre For Therapeutic Research
11006272 59 A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization.BDB Schering-Plough Research Institute