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41 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27777004 90 Identification of the minimum PAR4 inhibitor pharmacophore and optimization of a series of 2-methoxy-6-arylimidazo[2,1-b][1,3,4]thiadiazoles.EBI Vanderbilt University Medical Center
27774122 8 Protease-Activated Receptor 1 (PAR-1) Antagonists as Potential Treatment for Acute Coronary Syndrome.EBI Therachem Research Medilab (India) Pvt. Ltd.
27075367 55 Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2.EBI BAYER Pharma AG
25937878 9 The chemistry and pharmacology of privileged pyrroloquinazolines.EBI Oregon Health& Science University
25176330 14 Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354.EBI Northwest Agriculture& Forestry University
24900880 12 Himbacine-derived thrombin receptor antagonists: c7-spirocyclic analogues of vorapaxar.EBI Merck Research Laboratories
23895492 49 Toward drugs for protease-activated receptor 2 (PAR2).EBI The University of Queensland
20137929 6 Exploration of a new series of PAR1 antagonists.EBI Centre de Recherche Pierre Fabre
22405832 24 Discovery of nor-seco himbacine analogs as thrombin receptor antagonists.EBI Pfizer Inc.
8960546 160 Development of potent thrombin receptor antagonist peptides.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
9873407 27 Thrombin receptor (PAR-1) antagonists. Heterocycle-based peptidomimetics of the SFLLR agonist motif.EBI R. W. Johnson Pharmaceutical Research Institute
20888225 17 Discovery of a vorapaxar analog with increased aqueous solubility.EBI Merck Research Laboratories
 54 Solid-phase parallel synthesis applied to lead optimization: Discovery of potent analogues of the GPIIb/IIIa antagonist RWJ-50042EBI TBA
18447380 28 Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity.EBI Schering-Plough Research Institute
17854166 33 Heterotricyclic himbacine analogs as potent, orally active thrombin receptor (protease activated receptor-1) antagonists.EBI Schering-Plough Research Institute
17574850 27 Himbacine derived thrombin receptor (PAR-1) antagonists: SAR of the pyridine ring.EBI Schering-Plough Research Institute
17490877 30 Himbacine derived thrombin receptor antagonists: discovery of a new tricyclic core.EBI Schering-Plough Research Institute
17201416 24 Metabolism-based identification of a potent thrombin receptor antagonist.EBI Schering-Plough Research Institute
16824760 22 Himbacine derived thrombin receptor (PAR-1) antagonists: structure-activity relationship of the lactone ring.EBI Schering-Plough Research Institute
16380251 31 Discovery and synthesis of a novel series of quinoline-based thrombin receptor (PAR-1) antagonists.EBI Schering-Plough Research Institute
16161991 50 Discovery of potent orally active thrombin receptor (protease activated receptor 1) antagonists as novel antithrombotic agents.EBI Schering-Plough Research Institute
12798334 18 High-affinity thrombin receptor (PAR-1) ligands: a new generation of indole-based peptide mimetic antagonists with a basic amine at the C-terminus.EBI Johnson & Johnson Pharmaceutical Research & Development
11814787 73 Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1).EBI Merck Research Laboratories
11597414 10 Potent, low molecular weight thrombin receptor antagonists.EBI Schering-Plough Research Institute
11591503 7 Discovery and initial structure-activity relationships of trisubstituted ureas as thrombin receptor (PAR-1) antagonists.EBI Merck Research Laboratories
11514149 86 Thrombin receptor (PAR-1) antagonists. Solid-phase synthesis of indole-based peptide mimetics by anchoring to a secondary amide.EBI The R. W. Johnson Pharmaceutical Research Institute
11297447 18 Discovery and optimization of a novel series of thrombin receptor (par-1) antagonists: potent, selective peptide mimetics based on indole and indazole templates.EBI The R. W. Johnson Pharmaceutical Research Institute
10450984 16 Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists.EBI Schering-Plough Research Institute
10360749 97 Heterocycle-peptide hybrid compounds. Aminotriazole-containing agonists of the thrombin receptor (PAR-1).EBI The R. W. Johnson Pharmaceutical Research Institute
10230630 36 Thrombin inhibitors based on a propargylglycine template.EBI Biotech Research Institute
10021945 8 Photoactivatable peptides based on BMS-197525: a potent antagonist of the human thrombin receptor (PAR-1).EBI University at Stony Brook
7562949 61 Development of a potent thrombin receptor ligand.EBI Merck Research Laboratories