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126 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27163581 110 Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases.EBI University of Bath
26985304 23 Potential Use of Inhibitors of Tankyrases and PARP-1 as Treatment for Cancer and Other Diseases.EBI Therachem Research Medilab (India) Pvt. Ltd.
26652717 96 Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase-1/2 Inhibitor, as an Anticancer Agent.EBI BioMarin Pharmaceutical Inc.
26706174 46 Development and structural analysis of adenosine site binding tankyrase inhibitors.EBI University of Oulu
26231158 29 Selective inhibition of PARP10 using a chemical genetics strategy.EBI Oregon Health& Science University
26342868 14 Identification of novel PARP-1 inhibitors: Drug design, synthesis and biological evaluation.EBI China Pharmaceutical University
26312434 1 Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties.EBI Xinjiang Technical Institute of Physics and Chemistry
26222319 192 Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy.EBI Nerviano Medical Sciences Srl
26183543 87 Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics.EBI University of Oulu
26088338 50 Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODH.EBI University of Malaya
26026769 24 Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases.EBI University of Bath
26061013 55 Tankyrase 1 Inhibitors with Drug-like Properties Identified by Screening a DNA-Encoded Chemical Library.EBI £Philochem AG
25761096 17 Niraparib: A Poly(ADP-ribose) Polymerase (PARP) Inhibitor for the Treatment of Tumors with Defective Homologous Recombination.EBI Istituto di Ricerche di Biologia Molecolare
25899312 6 Design, synthesis and biological evaluation of pyridazino[3,4,5-de]quinazolin-3(2H)-one as a new class of PARP-1 inhibitors.EBI Peking University
25847771 121 Towards small molecule inhibitors of mono-ADP-ribosyltransferases.EBI Karolinska Institutet
25555733 11 Synthesis and biological evaluation of isoindoloisoquinolinone, pyroloisoquinolinone and benzoquinazolinone derivatives as poly(ADP-ribose) polymerase-1 inhibitors.EBI Pondicherry University
25086680 11 Synthesis and biological evaluation of substituted 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors.EBI Beijing Institute of Pharmacology and Toxicology
24922587 45 Discovery and structure-activity relationship of novel 2,3-dihydrobenzofuran-7-carboxamide and 2,3-dihydrobenzofuran-3(2H)-one-7-carboxamide derivatives as poly(ADP-ribose)polymerase-1 inhibitors.EBI St. John's University
24815508 29 Synthesis of isoquinolinone-based tricycles as novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors.EBI Chinese Academy of Sciences
24527792 8 Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors.EBI Universit£ degli Studi di Perugia
24521039 5 Nitric oxide (NO) releasing poly ADP-ribose polymerase 1 (PARP-1) inhibitors targeted to glutathione S-transferase P1-overexpressing cancer cells.EBI Frederick National Laboratory for Cancer Research
24503274 7 Synthesis, [8F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography.EBI Washington University in Saint Louis
24398383 24 7-Azaindole-1-carboxamides as a new class of PARP-1 inhibitors.EBI Universit£ di Milano
24388690 48 Novel PARP-1 inhibitors based on a 2-propanoyl-3H-quinazolin-4-one scaffold.EBI R&D Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
24188023 32 Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3.EBI Ume£ University
24074844 6 Identification of novel PARP-1 inhibitors by structure-based virtual screening.EBI St. John's University
24116873 16 Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.EBI University of Oulu
23879431 11 Structure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases.EBI Novartis Institutes for Biomedical Research Incorporated
23844574 71 Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor.EBI Novartis Institutes for Biomedical Research
23849206 22 One-pot tandem Hurtley-retro-Claisen-cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs.EBI University of Bath
23850199 89 Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose)polymerase inhibitors.EBI Takeda California
23701517 12 Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors.EBI Amgen Inc.
23672613 8 Fragment-based ligand design of novel potent inhibitors of tankyrases.EBI Nanyang Technological University
23522835 7 In silico identification of poly(ADP-ribose)polymerase-1 inhibitors and their chemosensitizing effects against cisplatin-resistant human gastric cancer cells.EBI Sungkyunkwan [corrected] University
23481647 9 Design, synthesis and biological evaluation of novel imidazo[4,5-c]pyridinecarboxamide derivatives as PARP-1 inhibitors.EBI China Pharmaceutical University
23574272 30 Screening and structural analysis of flavones inhibiting tankyrases.EBI University of Oulu
23473053 35 Design, synthesis, and biological evaluation of a series of benzo[de][1,7]naphthyridin-7(8H)-ones bearing a functionalized longer chain appendage as novel PARP1 inhibitors.EBI Chinese Academy of Sciences
23316926 12 Discovery of a class of novel tankyrase inhibitors that bind to both the nicotinamide pocket and the induced pocket.EBI Amgen Inc.
21413808 170 Synopsis of some recent tactical application of bioisosteres in drug design.EBI Bristol-Myers Squibb Pharmaceutical Research and Development
22766219 67 Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer.EBI Abbott Laboratories
22233320 19 Structural basis of selective inhibition of human tankyrases.EBI Abo Akademi University
22260203 73 [1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding.EBI Novartis Institutes for Biomedical Research
21634396 55 Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist.EBI Cephalon, Inc.
20565110 7 Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor.EBI Karolinska Institutet
17074482 31 Novel poly(ADP-ribose) polymerase-1 inhibitors.EBI Cephalon Inc.
12825952 31 Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries.EBI Guilford Pharmaceuticals Inc
11425538 29 Synthesis of substituted 5[H]phenanthridin-6-ones as potent poly(ADP-ribose)polymerase-1 (PARP1) inhibitors.EBI Guilford Pharmaceuticals Inc.
22365563 29 Synthesis and SAR optimization of quinazolin-4(3H)-ones as poly(ADP-ribose)polymerase-1 inhibitors.EBI St. John's University
22153339 27 Novel poly(ADP-ribose) polymerase-1 inhibitors.EBI Cephalon, Inc.
21692479 27 Discovery and structure-activity relationships of modified salicylanilides as cell permeable inhibitors of poly(ADP-ribose) glycohydrolase (PARG).EBI University of Arizona
21417348 48 5-Benzamidoisoquinolin-1-ones and 5-(κ-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2).EBI University of Bath
21174434 13 Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer.EBI Cylene Pharmaceuticals
20364863 30 Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic.EBI Johns Hopkins University Brain Science Institute
19873981 34 Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.EBI IRBM/Merck Research Labs Rome
20337371 79 Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor.EBI Abbott Laboratories
20189385 18 Synthesis and evaluation of tricyclic derivatives containing a non-aromatic amide as inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).EBI Jeil Pharmaceutical Co., Ltd.
20045315 26 Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer.EBI Abbott Laboratories
20031401 54 Identification and SAR of novel pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).EBI IRBM/Merck Research Laboratories
20022747 35 Development of substituted 6-[4-fluoro-3-(piperazin-1-ylcarbonyl)benzyl]-4,5-dimethylpyridazin-3(2H)-ones as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors active in BRCA deficient cells.EBI Merck Research Laboratories Rome
20015648 94 Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).EBI IRBM-Merck Research Laboratories Rome
20007017 45 Synthesis and biological evaluation of substituted 2-phenyl-2H-indazole-7-carboxamides as potent poly(ADP-ribose) polymerase (PARP) inhibitors.EBI IRBM-Merck Research Laboratories Rome
19800803 16 Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors.EBI Sookmyung Women's University
19888760 44 Synthesis and evaluation of a new generation of orally efficacious benzimidazole-based poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors as anticancer agents.EBI Abbott Laboratories
19553114 38 Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).EBI Abbott Laboratories
19553107 27 Identification of aminoethyl pyrrolo dihydroisoquinolinones as novel poly(ADP-ribose) polymerase-1 inhibitors.EBI IRBM--Merck Research Laboratories Rome
19541484 45 Identification of substituted pyrazolo[1,5-a]quinazolin-5(4H)-one as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors.EBI IRBM - Merck Research Laboratories Rome
19354255 10 Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3.EBI Institutet
19125579 58 Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors.EBI Huazhong University of Science and Technology
19117416 18 Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor.EBI University of Bath
18586490 40 Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituent.EBI Abbott Laboratories
17804225 33 Rational design of conformationally restricted quinazolinone inhibitors of poly(ADP-ribose)polymerase.EBI Astellas Pharma Inc.
16359865 22 Synthesis and structure-activity relationships of novel pyrrolocarbazole lactam analogs as potent and cell-permeable inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).EBI Cephalon, Inc.
16290935 17 Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors.EBI Cephalon, Inc.
16290932 33 Phthalazinones 2: Optimisation and synthesis of novel potent inhibitors of poly(ADP-ribose)polymerase.EBI KuDOS Pharmaceuticals Ltd
16098744 18 4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors.EBI Fujisawa Pharmaceutical Co., Ltd.
15837300 30 Phthalazinones. Part 1: The design and synthesis of a novel series of potent inhibitors of poly(ADP-ribose)polymerase.EBI KuDOS Horsham Ltd
15481984 45 Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase.EBI Pfizer Global R&D--La Jolla Laboratories
15293985 33 Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase.EBI Fujisawa Pharmaceutical Co., Ltd.
15109627 16 Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors.EBI University of Newcastle
12852955 25 Design and synthesis of poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors. Part 3: In vitro evaluation of 1,3,4,5-tetrahydro-benzo[c][1,6]- and [c][1,7]-naphthyridin-6-ones.EBI Guilford Pharmaceuticals Inc.
12519059 10 Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors.EBI Pfizer Global R&D
12408707 32 Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure.EBI Pfizer Global Research and Development
12372530 75 Substituted uracil derivatives as potent inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).EBI Bayer AG
11689065 27 Modeling of poly(ADP-ribose)polymerase (PARP) inhibitors. Docking of ligands and quantitative structure-activity relationship analysis.EBI Università di Perugia
11063605 36 Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase.EBI The University
27866910 9 Proteome-wide Profiling of Clinical PARP Inhibitors Reveals Compound-Specific Secondary Targets.BDB H. Lee Moffitt Cancer Center & Research Institute
27667561 16 Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage.BDB University of Oulu
23742272 9 PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3.BDB Ume£ University
16288880 41 Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling.BDB Fujisawa Pharmaceutical Co. Ltd
18713665 23 Identification of ring-fused pyrazolo pyridin-2-ones as novel poly(ADP-ribose)polymerase-1 inhibitors.BDB Deltagen Research Laboratories
18579376 23 Novel alkoxybenzamide inhibitors of poly(ADP-ribose) polymerase.BDB KuDOS Pharmaceuticals Ltd
18800822 40 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1.BDB KuDOS Pharmaceuticals Ltd.
16078828 25 Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone.BDB Inotek Pharmaceuticals Corporation
18809672 30 Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors.BDB University of Konstanz
19143569 36 Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer.BDB Abbott Laboratories
18541433 45 Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer.BDB Abbott Laboratories