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130 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27597413 58 Development of highly potent phosphodiesterase 4 inhibitors with anti-neuroinflammation potential: Design, synthesis, and structure-activity relationship study of catecholamides bearing aromatic rings.EBI Southern Medical University
27606546 218 Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.EBI University of Navarra
27301679 21 Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket.EBI Takeda Pharmaceutical Company Limited
26978121 20 Discovery and modelling studies of natural ingredients from Gaultheria yunnanensis (FRANCH.) against phosphodiesterase-4.EBI Sun Yat-Sen University
26789933 100 Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases.EBI Intra-Cellular Therapies, Inc.
26935942 41 Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals.EBI Mercachem
26526739 35 Catecholic amides as potential selective phosphodiesterase 4D inhibitors: Design, synthesis, pharmacological evaluation and structure-activity relationships.EBI Southern Medical University
25866242 55 2-(Isopropylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as selective phosphodiesterase 7 inhibitors with potent in vivo efficacy.EBI Kaken Pharmaceutical Co. Ltd
25801159 36 Discovery of novel pyrazolopyrimidinone analogs as potent inhibitors of phosphodiesterase type-5.EBI CSIR-Indian Institute of Integrative Medicine
25754491 11 8-(3-chloro-4-methoxybenzyl)-8H-pyrido[2,3-d]pyrimidin-7-one derivatives as potent and selective phosphodiesterase 5 inhibitors.EBI Mitsubishi Tanabe Pharma Corporation
25529739 43 Discovery and SAR study of 2-(4-pyridylamino)thieno[3,2-d]pyrimidin-4(3H)-ones as soluble and highly potent PDE7 inhibitors.EBI Kyoto 607-8042
25456383 113 Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility.EBI TBA
25455484 26 The discovery of avanafil for the treatment of erectile dysfunction: a novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor.EBI Mitsubishi Tanabe Pharma Corporation
25442307 17 Design and synthesis of novel 5-(3,4,5-trimethoxybenzoyl)-4-aminopyrimidine derivatives as potent and selective phosphodiesterase 5 inhibitors: scaffold hopping using a pseudo-ring by intramolecular hydrogen bond formation.EBI Mitsubishi Tanabe Pharma Corporation
25432025 34 Discovery of a phosphodiesterase 9A inhibitor as a potential hypoglycemic agent.EBI Sun Yat-Sen University
24856068 48 Pharmacophore based virtual screening, molecular docking and biological evaluation to identify novel PDE5 inhibitors with vasodilatory activity.EBI Banasthali University
24758746 36 Discovery of a potent, selective, and orally active phosphodiesterase 10A inhibitor for the potential treatment of schizophrenia.EBI Janssen Research& Development
24702184 5 Thermodynamic and structural characterization of halogen bonding in protein-ligand interactions: a case study of PDE5 and its inhibitors.EBI Chinese Academy of Sciences (CAS)
23313637 14 Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease.EBI Columbia University
23260348 91 Discovery of a new series of [1,2,4]triazolo[4,3-a]quinoxalines as dual phosphodiesterase 2/phosphodiesterase 10 (PDE2/PDE10) inhibitors.EBI Janssen-Cilag S.A.
18045743 49 Bioactivities of a series of phosphodiesterase type 5 (PDE-5) inhibitors as modelled by MIA-QSAR.EBI Universidade Federal de Lavras-UFLA
18656371 47 In silico prediction of novel phosphodiesterase type-5 inhibitors derived from Sildenafil, Vardenafil and Tadalafil.EBI Universidade Federal de Lavras-UFLA
17553682 33 3D-QSAR studies on sildenafil analogues, selective phosphodiesterase 5 inhibitors.EBI Sungkyunkwan University
23137303 38 Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5.EBI Chinese Academy of Sciences
22985069 18 Structure-based discovery of highly selective phosphodiesterase-9A inhibitors and implications for inhibitor design.EBI Sun Yat-Sen University
22780914 35 Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a selective brain penetrant PDE9A inhibitor for the treatment of cognitive disorders.EBI Pfizer Inc.
22483586 10 Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor.EBI Sun Yat-Sen University
22377514 75 The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia.EBI Merck Research Laboratories
20400309 26 1-(2-(2,2,2-trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors.EBI Pfizer Global Research and Development
20443228 35 1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors.EBI Pfizer Global Research and Development
18778098 12 Potent inhibition of human phosphodiesterase-5 by icariin derivatives.EBI University of Milan
17337182 23 Potent and selective xanthine-based inhibitors of phosphodiesterase 5.EBI Novartis Institutes of Biomedical Research
15887951 29 The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.EBI Monash University (Parkville Campus)
15878277 42 Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3H)-one derivatives.EBI Chinese Academy of Sciences
12213052 15 Pyrimidinylpyrroloquinolones as highly potent and selective PDE5 inhibitors for treatment of erectile dysfunction.EBI Johnson& Johnson Pharmaceutical Research& Development
11405657 123 Novel, potent, and selective phosphodiesterase 5 inhibitors: synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives.EBI Tanabe Seiyaku Co., Ltd.
10891111 56 4-(3-Chloro-4-methoxybenzyl)aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5.EBI Eisai Company, Ltd.
10090791 77 Novel, potent, and selective phosphodiesterase-4 inhibitors as antiasthmatic agents: synthesis and biological activities of a series of 1-pyridylnaphthalene derivatives.EBI Tanabe Seiyaku Company, Ltd.
9191951 8 9-Benzyladenines: potent and selective cAMP phosphodiesterase inhibitors.EBI UPR 421 du CNRS
8709099 20 Novel selective PDE IV inhibitors as antiasthmatic agents. Synthesis and biological activities of a series of 1-aryl-2,3-bis(hydroxymethyl)naphthalene lignans.EBI Tan£be Seiyaku Company, Ltd.
7658441 89 Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities.EBI Biofor Inc.
8254606 50 Cyclic GMP phosphodiesterase inhibitors. 1. The discovery of a novel potent inhibitor, 4-((3,4-(methylenedioxy)benzyl)amino)-6,7,8-trimethoxyquinazoline.EBI Eisai Co. Ltd.
8388468 23 Cyclic nucleotide phosphodiesterase inhibition by imidazopyridines: analogues of sulmazole and isomazole as inhibitors of the cGMP specific phosphodiesterase.EBI SmithKline Beecham Pharmaceuticals
12824030 23 1,7- and 2,7-naphthyridine derivatives as potent and highly specific PDE5 inhibitors.EBI Tanabe Seiyaku Co., Ltd.
11755362 16 Synthesis of 4-(8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridine-6-yl)-benzoic acid: a potent and selective phosphodiesterase type 4D inhibitor.EBI Novartis Pharma AG
22222034 35 The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia.EBI Merck Research Laboratories
22142545 96 Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia.EBI Merck Research Laboratories
22100260 30 The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics.EBI Worldwide Medicinal Chemistry, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. davidrawson1@gmail.com
21988093 316 Highly potent, selective, and orally active phosphodiesterase 10A inhibitors.EBI Pfizer Inc.
21955943 47 Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region.EBI Pfizer Inc.
21983442 142 Synthesis and structure-activity relationship studies of dihydronaphthyridinediones as a novel structural class of potent and selective PDE7 inhibitors.EBI biocrea GmbH
19447034 76 Discovery of selective PDE4B inhibitors.EBI Asahi Kasei Pharma Corporation
21602043 50 Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors.EBI H. Lundbeck A/S
21570840 44 Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: part 1.EBI Merck Research Laboratories
21530250 73 Phosphodiesterase inhibitors. Part 1: Synthesis and structure-activity relationships of pyrazolopyridine-pyridazinone PDE inhibitors developed from ibudilast.EBI Heriot-Watt University
21189023 66 Synthesis and molecular modeling of novel tetrahydro-ß-carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties.EBI German University in Cairo
21087867 30 Synthesis and SAR study of new phenylimidazole-pyrazolo[1,5-c]quinazolines as potent phosphodiesterase 10A inhibitors.EBI Universit£ di Sassari
20937560 54 Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A(1) adenosine receptor ligands.EBI Dipartimento di Scienze Farmaceutiche
20709547 69 The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors.EBI Merck Frosst Centre for Therapeutic Research
20450197 80 Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors.EBI Biotie Therapies GmbH
20206015 22 Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective.EBI German University in Cairo
19856955 2 Lorneic acids, trialkyl-substituted aromatic acids from a marine-derived actinomycete.EBI Nippon Suisan Kaisha, Ltd
20053559 55 Design, synthesis, and evaluation of 2-aryl-7-(3',4'-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines as novel PDE-4 inhibitors.EBI Korea Research Institute of Chemical Technology
20196613 32 Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5).EBI Pfizer Global Research and Development
19631533 126 Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.EBI Pfizer Global Research and Development
19919087 55 Identification of a brain penetrant PDE9A inhibitor utilizing prospective design and chemical enablement as a rapid lead optimization strategy.EBI Pfizer Global Research and Development
19540112 33 Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors.EBI Pfizer Global Research and Development
19539468 6 Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.EBI Pfizer Global Research and Development
 24 Imidazotriazinone inhibitors of the Ca2+-calmodulin sensitive phosphodiesterase (PDE I)EBI TBA
 15 Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunctionEBI TBA
19339180 69 The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents.EBI Pfizer Global Research and Development
19272774 12 Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
19049349 107 Design, synthesis, and structure-activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors.EBI Georgia State University
18951784 19 Highly potent and selective chiral inhibitors of PDE5: an illustration of Pfeiffer's rule.EBI Pfizer Global Research and Development
18393409 16 Synthesis and pharmacological evaluations of sildenafil analogues for treatment of erectile dysfunction.EBI State University of Campinas
16913726 33 Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase 5 (PDE5) inhibitory activity as potential agents for treatment of erectile dysfunction.EBI Università di Firenze
16337379 14 Identification of phosphodiesterase-1 and 5 dual inhibitors by a ligand-based virtual screening optimized for lead evolution.EBI Sumitomo Pharmaceuticals Co., Ltd
16275071 26 A new chemical tool for exploring the physiological function of the PDE2 isozyme.EBI Pfizer, Inc.
16263279 37 A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function.EBI Pfizer, Inc.
16005625 162 Discovery of hydroxamic acid analogs as dual inhibitors of phosphodiesterase-1 and -5.EBI Sumitomo Pharmaceuticals Co., Ltd
15993055 61 Comparison of different heterocyclic scaffolds as substrate analog PDE5 inhibitors.EBI BAYER HealthCare AG
15837329 37 New pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective PDE5 inhibitors.EBI Rhône-Poulenc Rorer
15837326 51 Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male ED.EBI Schering-Plough Research Institute
15324877 90 Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives.EBI Pfizer Global Research and Development
15324876 94 Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1.EBI Pfizer Global Research and Development
15324874 169 Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies.EBI Pfizer Global Research and Development
15149695 3 New substituted triaza-benzo[cd]azulen-9-ones as promising phosphodiesterase-4 inhibitors.EBI Pfizer Global Research and Development
15125967 12 Identification of purine inhibitors of phosphodiesterase 7 (PDE7).EBI Bristol-Myers Squibb Pharmaceutical Research Institute
15080987 14 Synthesis and phosphodiesterase 5 inhibitory activity of new sildenafil analogues containing a phosphonate group in the 5(')-sulfonamide moiety of phenyl ring.EBI Ewha Womans University
15006407 12 Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
14980684 52 SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction.EBI Schering-Plough Research Institute
14736245 16 Structure-activity relationships of N-acyl pyrroloquinolone PDE-5 inhibitors.EBI Johnson and Johnson Pharmaceutical Research and Development LLC
12668004 53 Design, synthesis and biological activity of beta-carboline-based type-5 phosphodiesterase inhibitors.EBI Pfizer Global Research and Development
12639576 34 Synthesis and biological activities of novel beta-carbolines as PDE5 inhibitors.EBI Johnson & Johnson Pharmaceutical Research & Development L.L.C.
12570368 9 Substituted pyrazolopyridopyridazines as orally bioavailable potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
12540243 29 Furoyl and benzofuroyl pyrroloquinolones as potent and selective PDE5 inhibitors for treatment of erectile dysfunction.EBI Johnson & Johnson Pharmaceutical Research & Development L.L.C.
12372521 21 Design and synthesis of xanthine analogues as potent and selective PDE5 inhibitors.EBI Schering-Plough Research Institute
12182866 42 8-Aryl xanthines potent inhibitors of phosphodiesterase 5.EBI Novartis Horsham Research Centre
11958981 7 Imidazo[5,1-f]triazin-4(3H)-ones, a new class of potent PDE 5 inhibitors.EBI BAYER AG
11606139 11 Synthesis of 1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole analogues as novel antiplatelet agents.EBI Institute of Pharmaceutical Chemistry
11549447 6 The discovery of novel, potent and selective PDE5 inhibitors.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
11297448 11 Substituted pyrazolopyridines as potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
11150175 17 Optimization of substituted N-3-benzylimidazoquinazolinone sulfonamides as potent and selective PDE5 inhibitors.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
10753463 5 N-3-substituted imidazoquinazolinones: potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
10197972 133 1-Arylnaphthalene lignan: a novel scaffold for type 5 phosphodiesterase inhibitor.EBI Tanabe Seiyaku Company, Ltd.
9873594 1 Aryl sulfonamides as selective PDE4 inhibitors.EBI Chiroscience Ltd
9719589 13 4-Benzylamino-1-chloro-6-substituted phthalazines: synthesis and inhibitory activity toward phosphodiesterase 5.EBI Eisai Company, Ltd.
8648603 101 Synthesis and cyclic GMP phosphodiesterase inhibitory activity of a series of 6-phenylpyrazolo[3,4-d]pyrimidones.EBI Laboratories Glaxo Wellcome Centre de Recherches
8544172 3 Introduction of a conformational switching element on a pyrrolidine ring. Synthesis and evaluation of (R*,R*)-(+/-)-methyl 3-acetyl-4-[3- (cyclopentyloxy)-4-methoxyphenyl]-3-methyl-1-pyrrolidinecarboxylate, a potent and selective inhibitor of cAMP-specific phosphodiesterase.EBI Glaxo Wellcome Research
8201604 96 Selective type IV phosphodiesterase inhibitors as antiasthmatic agents. The syntheses and biological activities of 3-(cyclopentyloxy)-4-methoxybenzamides and analogues.EBI Rhône-Poulenc Rorer Central Research
8120866 54 Inhibition of cyclic nucleotide phosphodiesterase by derivatives of 1,3-bis(cyclopropylmethyl)xanthine.EBI SmithKline Beecham Pharmaceuticals
8027992 49 Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity.EBI Eisai Company Ltd.
6620311 6 Optical resolution, absolute configuration, and activity of the enantiomers of proxyphylline.EBI TBA
 8 Synthesis,MolecularModeling, and Biological Evaluation of Novel Tetrahydro--Carboline Hydantoin and Tetrahydro--Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 InhibitorsBDB German University in Cairo
22356915 27 Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors.BDB University of North Carolina
22284362 91 Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen.BDB Boston College
16759100 33 A novel series of potent and selective PDE5 inhibitors with potential for high and dose-independent oral bioavailability.BDB Pfizer