BindingDB logo
myBDB logout

52 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27842798 66 Synthesis, COX-1/2 inhibition activities and molecular docking study of isothiazolopyridine derivatives.EBI Wroclaw Medical University
26774035 16 Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity.EBI University of Siena
25408841 108 Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors.EBI Vanderbilt University School of Medicine
24629448 2 Synthetic approaches to the 2012 new drugs.EBI PharmaPhase Co., Ltd
24656662 33 Synthesis, biological evaluation, and docking analysis of a novel family of 1-methyl-1H-pyrrole-2,5-diones as highly potent and selective cyclooxygenase-2 (COX-2) inhibitors.EBI Kyung Hee University
23534442 32 Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors.EBI Universit£ degli Studi di Siena
23353741 117 Synthesis and biological evaluation of some novel resveratrol amide derivatives as potential anti-tumor agents.EBI Hefei University of Technology
23432095 160 Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17ß-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer.EBI Vanderbilt University School of Medicine
15225716 26 Quantitative structure-activity relationship analysis of a series of 2,3-diaryl benzopyran analogues as novel selective cyclooxygenase-2 inhibitors.EBI Devi Ahilya Vishwavidyalaya
18023931 30 QSAR analysis of 1,3-diaryl-4,5,6,7-tetrahydro-2H-isoindole derivatives as selective COX-2 inhibitors.EBI Dr HS Gour University
12383010 114 Computer-aided design of selective COX-2 inhibitors: comparative molecular field analysis, comparative molecular similarity indices analysis, and docking studies of some 1,2-diarylimidazole derivatives.EBI University of Hyderabad
12383007 100 Inhibitory mode of 1,5-diarylpyrazole derivatives against cyclooxygenase-2 and cyclooxygenase-1: molecular docking and 3D QSAR analyses.EBI Chinese Academy of Sciences
23040893 3 Synthesis of 1,5-diarylhaloimidazole analogs and their inhibitory activities against PGE2 production from LPS-treated RAW 264.7 cells.EBI College of Pharmacy
23131542 16 Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme.EBI Universit£ La Sapienza
22263894 23 Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold.EBI Vanderbilt Institute of Chemical Biology
21318094 25 [I]-Celecoxib Analogues as SPECT Tracers of Cyclooxygenase-2 in Inflammation.EBI TBA
20188577 23 In silico search for multi-target anti-inflammatories in Chinese herbs and formulas.EBI King's College London
17434872 38 Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib.EBI Vanderbilt Institute for Chemical Biology
11101350 72 1,3-Diaryl-4,5,6,7-tetrahydro-2H-isoindole derivatives: a new series of potent and selective COX-2 inhibitors in which a sulfonyl group is not a structural requisite.EBI Institut de Recherche Servier
15109651 53 Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities.EBI Yeungnam University
21992176 52 Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties.EBI Universit£"Sapienza"
22172309 12 Novel bioactive metabolites of dipyrone (metamizol).EBI Philipps-Universit£t
19476340 2 Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds.EBI Ghent University-UGent
21524587 6 Synthesis and evaluation of carbaborane derivatives of indomethacin as cyclooxygenase inhibitors.EBI Universit£t Leipzig
21381754 15 Synthesis and biological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives for the treatment of inflammatory diseases.EBI Sichuan University
20970329 8 Sulfonamide derivatives of styrylheterocycles as a potent inhibitor of COX-2-mediated prostaglandin E2 production.EBI Seoul National University
20129783 30 Podophyllotoxin analogues active versus Trypanosoma brucei.EBI Vanderbilt University School of Medicine
20056549 12 Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production.EBI National Taiwan University
19957931 66 Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation.EBI Universit£ La Sapienza
19427206 5 The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivatives.EBI Vanderbilt University School of Medicine
19286379 8 Synthesis and anti-inflammatory activity of the major metabolites of imrecoxib.EBI Chinese Academy of Medical Sciences
19233646 7 Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study.EBI University of Medicine and Pharmacy at Ho Chi Minh City
19041241 21 Synthesis of biflavones having a 6-O-7'' linkage and effects on cyclooxygenase-2 and inducible nitric oxide synthase.EBI Kangwon National University
18752957 44 Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.EBI Università La Sapienza
18598017 28 Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity.EBI Universita di Siena
17125227 3 Triterpene saponins from clematis mandshurica.EBI Peking University Health Science Center
17915854 38 Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity.EBI Università La Sapienza
17341061 21 Structural and functional basis of cyclooxygenase inhibition.EBI Institute for Chemical Biology and Center in Molecular Toxicology
17258905 22 Design, synthesis, and biological evaluation of substituted 2-alkylthio-1,5-diarylimidazoles as selective COX-2 inhibitors.EBI Tehran University of Medical Sciences
16153836 7 Synthesis of 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new [18F]fluorinated analogue of valdecoxib, as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomography.EBI David Geffen School of Medicine at University of California
15857149 24 1,5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors.EBI Università "La Sapienza"
11965379 91 Enantiospecific, selective cyclooxygenase-2 inhibitors.EBI Vanderbilt University School of Medicine
11844663 54 Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.EBI Vanderbilt University School of Medicine
10197960 171 Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.EBI Warner-Lambert Company
10197959 92 Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.EBI Warner-Lambert Company
27588346 50 Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors.BDB Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine
10639181 68 Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.BDB Vanderbilt University School of Medicine