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27 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27397499 21 Discovery of novel dihydrobenzofuran cyclopropane carboxylic acid based calcium sensing receptor antagonists for the treatment of osteoporosis.EBI Merck Research Laboratories
26752095 12 Design and synthesis of calindol derivatives as potent and selective calcium sensing receptor agonists.EBI CNRS
26516782 59 Selective Allosteric Antagonists for the G Protein-Coupled Receptor GPRC6A Based on the 2-Phenylindole Privileged Structure Scaffold.EBI University of Copenhagen
24215889 21 Metabolism-guided discovery of a potent and orally bioavailable urea-based calcimimetic for the treatment of secondary hyperparathyroidism.EBI Amgen Inc.
23499504 31 New potent calcimimetics: II. Discovery of benzothiazole trisubstituted ureas.EBI Galapagos SASU
23465611 61 New potent calcimimetics: I. Discovery of a series of novel trisubstituted ureas.EBI Galapagos SASU
20727747 15 Discovery of a class of calcium sensing receptor positive allosteric modulators; 1-(benzothiazol-2-yl)-1-phenylethanols.EBI ACADIA Pharmaceuticals AB
19821575 47 Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues.EBI GlaxoSmithKline
16913701 8 N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity.EBI CNRS
15149704 3 N2-benzyl-N1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1,2-diamines and conformationally restrained indole analogues: development of calindol as a new calcimimetic acting at the calcium sensing receptor.EBI UPR 2301 Centre National de la Recherche Scientifique
19442519 14 The discovery of novel calcium sensing receptor negative allosteric modulators.EBI Pfizer Inc.
21353570 25 Novel and potent calcium-sensing receptor antagonists: discovery of (5R)-N-[1-ethyl-1-(4-ethylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide monotosylate (TAK-075) as an orally active bone anabolic agent.EBI Takeda Pharmaceutical Company Ltd
21306167 26 Discovery of novel and potent orally active calcium-sensing receptor antagonists that stimulate pulselike parathyroid hormone secretion: synthesis and structure-activity relationships of tetrahydropyrazolopyrimidine derivatives.EBI Takeda Pharmaceutical Company Limited
21055954 21 Synthesis and structure-activity relationship of tetrahydropyrazolopyrimidine derivatives--a novel structural class of potent calcium-sensing receptor antagonists.EBI Takeda Pharmaceutical Company Limited
20708930 36 The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core.EBI Amgen Inc.
20685119 37 Penta-substituted benzimidazoles as potent antagonists of the calcium-sensing receptor (CaSR-antagonists).EBI Novartis Institutes for BioMedical Research
20472433 37 New aminopropandiol derivatives as orally available and short-acting calcium-sensing receptor antagonists.EBI Central Pharmaceutical Research Institute
20218623 68 Emerging targets in osteoporosis disease modification.EBI Amgen, Inc.
20158186 48 1-Alkyl-4-phenyl-6-alkoxy-1H-quinazolin-2-ones: a novel series of potent calcium-sensing receptor antagonists.EBI Novartis Institutes for BioMedical Research
19835382 18 Discovery and optimization of substituted 1-(1-phenyl-1H-pyrazol-3-yl)methanamines as potent and efficacious type II calcimimetics.EBI Amgen Inc.
19492813 56 Antagonists of the calcium receptor I. Amino alcohol-based parathyroid hormone secretagogues.EBI GlaxoSmithKline
16216508 44 Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
15863312 17 Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones.EBI NPS Pharmaceuticals, Inc.
15745796 22 3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis.EBI NPS Pharmaceuticals, Inc.
19143533 44 Discovery and Structure-Activity Relationships of Trisubstituted Pyrimidines/Pyridines as Novel Calcium-Sensing Receptor Antagonists.BDB Bristol-Myers Squibb Company