Found 40 hits for monomerid = 16285 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank MMDB PDB Article PubMed
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Takeda Pharmaceutical Company Ltd.
| Assay Description Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay.... |
J Med Chem 50: 2297-300 (2007)
Article DOI: 10.1021/jm070104l BindingDB Entry DOI: 10.7270/Q2TM78C5 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Acyl-protein thioesterase 1/2
(Rattus norvegicus) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| PubMed
| n/a | n/a | 1.47E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University First Hospital
Curated by ChEMBL
| Assay Description Inhibition of FAP in human U87MG cells using Suc-Gly-Pro-AMC as substrate by fluorescence based assay |
Bioorg Med Chem Lett 30: (2020)
|
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase-IV (DDP-4)
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB
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| PDB Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
| Assay Description The DPP-4 Drug Discovery Kit (Enzo Life Sciences International, Inc.) was used for the assay of inhibition of DPP-4 activity. The assay is based on t... |
Chem Biol Drug Des 86: 849-56 (2015)
Article DOI: 10.1111/cbdd.12560 BindingDB Entry DOI: 10.7270/Q2FJ2FJG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB MMDB
Reactome pathway KEGG
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| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
XuanZhu Pharma
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DPP4 pre-incubated with compound for 15 mins before substrate addition by luminescence assay |
ACS Med Chem Lett 5: 921-6 (2014)
Article DOI: 10.1021/ml5001905 BindingDB Entry DOI: 10.7270/Q2N29ZQM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase VIII
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
XuanZhu Pharma
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DPP8 pre-incubated with compound for 15 mins before substrate addition by luminescence assay |
ACS Med Chem Lett 5: 921-6 (2014)
Article DOI: 10.1021/ml5001905 BindingDB Entry DOI: 10.7270/Q2N29ZQM |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 9
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
XuanZhu Pharma
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DPP9 pre-incubated with compound for 15 mins before substrate addition by luminescence assay |
ACS Med Chem Lett 5: 921-6 (2014)
Article DOI: 10.1021/ml5001905 BindingDB Entry DOI: 10.7270/Q2N29ZQM |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 9
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of DPP9 (unknown origin) preincubated for 20 mins followed by Gly-Pro-AMC addition measured for 50 mins by continuous fluorescence assay |
ACS Med Chem Lett 7: 498-501 (2016)
BindingDB Entry DOI: 10.7270/Q2CN75SM |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase VIII
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of recombinant DPP8 (unknown origin) preincubated for 20 mins followed by Ala-Pro-AFC addition measured for 40 mins by continuous fluoresc... |
ACS Med Chem Lett 7: 498-501 (2016)
BindingDB Entry DOI: 10.7270/Q2CN75SM |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 2 (DPP II)
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB MMDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of QPP (unknown origin) preincubated for 30 mins followed by Nle-Pro-AMC addition measured for 50 mins by continuous fluorescence assay |
ACS Med Chem Lett 7: 498-501 (2016)
BindingDB Entry DOI: 10.7270/Q2CN75SM |
More data for this Ligand-Target Pair | |
Lysosomal phospholipase A1
(Rattus norvegicus) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB MMDB
Reactome pathway KEGG
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| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of FAP (unknown origin) preincubated for 20 mins followed by Nle-Pro-AMC addition measured for 40 mins by continuous fluorescence assay |
ACS Med Chem Lett 7: 498-501 (2016)
BindingDB Entry DOI: 10.7270/Q2CN75SM |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB MMDB
Reactome pathway KEGG
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| DrugBank MMDB PDB PubMed
| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human DPP4 preincubated for 30 mins followed by Gly-Pro-AMC addition measured for 50 mins by continuous fluorescence assay |
ACS Med Chem Lett 7: 498-501 (2016)
BindingDB Entry DOI: 10.7270/Q2CN75SM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB MMDB
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| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda San Diego, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human DPP4 |
J Med Chem 54: 510-24 (2011)
Article DOI: 10.1021/jm101016w BindingDB Entry DOI: 10.7270/Q24X5828 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase VIII
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda San Diego, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human DPP8 |
J Med Chem 54: 510-24 (2011)
Article DOI: 10.1021/jm101016w BindingDB Entry DOI: 10.7270/Q24X5828 |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB MMDB
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| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of DPP4 in human plasma assessed as formation of 7-amino-4-methylcoumarin from glycyl-L-proline 4-methylcoumaryl-7-amide by fluorescence a... |
Bioorg Med Chem 19: 5490-9 (2011)
Article DOI: 10.1016/j.bmc.2011.07.042 BindingDB Entry DOI: 10.7270/Q2T72HT6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB MMDB
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| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of DPP4 after 20 mins by fluorescence assay |
Eur J Med Chem 46: 71-6 (2010)
Article DOI: 10.1016/j.ejmech.2010.10.016 BindingDB Entry DOI: 10.7270/Q28P61HD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase VIII
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of DPP8 after 20 mins by fluorescence assay |
Eur J Med Chem 46: 71-6 (2010)
Article DOI: 10.1016/j.ejmech.2010.10.016 BindingDB Entry DOI: 10.7270/Q28P61HD |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 9
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of DPP9 after 20 mins by fluorescence assay |
Eur J Med Chem 46: 71-6 (2010)
Article DOI: 10.1016/j.ejmech.2010.10.016 BindingDB Entry DOI: 10.7270/Q28P61HD |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 9
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of DPP9 |
Bioorg Med Chem 20: 5864-83 (2012)
Article DOI: 10.1016/j.bmc.2012.07.046 BindingDB Entry DOI: 10.7270/Q2FX7BJX |
More data for this Ligand-Target Pair | |
Fibroblast activation protein alpha
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB MMDB
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| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of FAPalpha |
Bioorg Med Chem 20: 5864-83 (2012)
Article DOI: 10.1016/j.bmc.2012.07.046 BindingDB Entry DOI: 10.7270/Q2FX7BJX |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB MMDB
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| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of DPP4 in human plasma using Gly-Pro-AMC as substrate by fluorimetric analysis |
Bioorg Med Chem 20: 5864-83 (2012)
Article DOI: 10.1016/j.bmc.2012.07.046 BindingDB Entry DOI: 10.7270/Q2FX7BJX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase 2 (DPP II)
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB MMDB
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| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of human DPP2 using Lys-Ala-AMC as substrate by fluorimetric analysis |
Bioorg Med Chem 20: 5864-83 (2012)
Article DOI: 10.1016/j.bmc.2012.07.046 BindingDB Entry DOI: 10.7270/Q2FX7BJX |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase VIII
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of DPP8 |
Bioorg Med Chem 20: 5864-83 (2012)
Article DOI: 10.1016/j.bmc.2012.07.046 BindingDB Entry DOI: 10.7270/Q2FX7BJX |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 9
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of DPP9 |
Eur J Med Chem 52: 205-12 (2012)
Article DOI: 10.1016/j.ejmech.2012.03.015 BindingDB Entry DOI: 10.7270/Q2B8594W |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase VIII
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of DPP8 |
Eur J Med Chem 52: 205-12 (2012)
Article DOI: 10.1016/j.ejmech.2012.03.015 BindingDB Entry DOI: 10.7270/Q2B8594W |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB MMDB
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| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human DPP4 after 10 mins |
Eur J Med Chem 52: 205-12 (2012)
Article DOI: 10.1016/j.ejmech.2012.03.015 BindingDB Entry DOI: 10.7270/Q2B8594W |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB MMDB
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| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DPP4 using Gly-Pro-7-amido-4-methyl-coumarin as substrate incubated for 15 mins by fluorescence assay |
J Med Chem 60: 6480-6515 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00010 BindingDB Entry DOI: 10.7270/Q2PK0JDP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB MMDB
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| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Jiao Tong University
Curated by ChEMBL
| Assay Description Inhibition of human DPP4 using A-P-7-amido-4-trifluoromethylcoumarin as substrate pretreated for 10 mins followed by substrate addition measured afte... |
Bioorg Med Chem 26: 903-912 (2018)
Article DOI: 10.1016/j.bmc.2018.01.006 BindingDB Entry DOI: 10.7270/Q2FB55J7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase 8/9
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangxi Medical University
Curated by ChEMBL
| Assay Description Inhibition of DPP8 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv... |
Eur J Med Chem 180: 509-523 (2019)
Article DOI: 10.1016/j.ejmech.2019.07.045 |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 9
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangxi Medical University
Curated by ChEMBL
| Assay Description Inhibition of DPP9 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv... |
Eur J Med Chem 180: 509-523 (2019)
Article DOI: 10.1016/j.ejmech.2019.07.045 |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB MMDB
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| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangxi Medical University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo... |
Eur J Med Chem 180: 509-523 (2019)
Article DOI: 10.1016/j.ejmech.2019.07.045 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB MMDB
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| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH & Co. KG
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DPP4 (39 to 766 residues) using Ala-Pro-AFC as substrate incubated for 1 hr by fluorescence assay |
J Med Chem 59: 7466-77 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00475 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB MMDB
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| DrugBank MMDB PDB Article PubMed
| n/a | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH & Co. KG
Curated by ChEMBL
| Assay Description Binding affinity to human recombinant DPP4 (39 to 766 residues) by surface plasmon resonance analysis |
J Med Chem 59: 7466-77 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00475 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB MMDB
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| DrugBank MMDB PDB Article PubMed
| n/a | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH & Co. KG
Curated by ChEMBL
| Assay Description Binding affinity to human recombinant DPP4 (39 to 766 residues) at 5 uM by isothermal titration calorimetry |
J Med Chem 59: 7466-77 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00475 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase 9
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangxi Medical University
Curated by ChEMBL
| Assay Description Inhibition of recombinant full-length human N-terminal GST-tagged DPP9 expressed in Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 se... |
Bioorg Med Chem 27: 644-654 (2019)
Article DOI: 10.1016/j.bmc.2019.01.001 |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 8/9
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangxi Medical University
Curated by ChEMBL
| Assay Description Inhibition of recombinant full-length human N-terminal GST-tagged DPP8 expressed in Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 se... |
Bioorg Med Chem 27: 644-654 (2019)
Article DOI: 10.1016/j.bmc.2019.01.001 |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB MMDB
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| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangxi Medical University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 secs interval f... |
Bioorg Med Chem 27: 644-654 (2019)
Article DOI: 10.1016/j.bmc.2019.01.001 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase 9
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangxi Medical University
Curated by ChEMBL
| Assay Description Inhibition of recombinant full-length human N-terminal GST-tagged DPP9 expressed in Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 se... |
Bioorg Med Chem 27: 644-654 (2019)
Article DOI: 10.1016/j.bmc.2019.01.001 |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 8/9
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB
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UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
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DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangxi Medical University
Curated by ChEMBL
| Assay Description Inhibition of recombinant full-length human N-terminal GST-tagged DPP8 expressed in Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 se... |
Bioorg Med Chem 27: 644-654 (2019)
Article DOI: 10.1016/j.bmc.2019.01.001 |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB MMDB
Reactome pathway KEGG
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DrugBank MMDB PC cid PC sid PDB UniChem
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| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangxi Medical University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 secs interval f... |
Bioorg Med Chem 27: 644-654 (2019)
Article DOI: 10.1016/j.bmc.2019.01.001 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase VIII
(Homo sapiens (Human)) | BDBM16285
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O |r| Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1 | PDB
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antibodypedia GoogleScholar AffyNet
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DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Takeda Pharmaceutical Company Ltd.
| Assay Description Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay.... |
J Med Chem 50: 2297-300 (2007)
Article DOI: 10.1021/jm070104l BindingDB Entry DOI: 10.7270/Q2TM78C5 |
More data for this Ligand-Target Pair | |