BDBM28699 2-(4-chlorophenoxy)-2-methylpropanoic acid::CHEMBL683::Clofibrate::Clofibrinic acid::clofibric acid

SMILES: CC(C)(Oc1ccc(Cl)cc1)C(O)=O

InChI Key: InChIKey=TXCGAZHTZHNUAI-UHFFFAOYSA-N

Data: 1 KI  16 EC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 28699   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Intestinal fatty acid-binding protein (hIFABP) (Homo sapiens (Human))	BDBM28699 (2-(4-chlorophenoxy)-2-methylpropanoic acid | CHEMB...) Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(O)=O Show InChI InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.77E+4	-12.3	n/a	n/a	n/a	n/a	n/a	n/a	293.15
Monash University					Assay Description Briefly, steady-state fluorescence spectra of ANS binding was monitored by measuring the increase in fluorescence signal between 450?550 nm following...				ACS Chem Biol 9: 2526-34 (2014) Article DOI: 10.1021/cb5005178 BindingDB Entry DOI: 10.7270/Q2348J4C
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma (Mus musculus)	BDBM28699 (2-(4-chlorophenoxy)-2-methylpropanoic acid | CHEMB...) Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(O)=O Show InChI InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	6.00E+5	n/a	n/a	n/a	n/a
Glaxo Wellcome Research and Development Curated by ChEMBL					Assay Description In vitro transcriptional activation of Peroxisome proliferator activated receptor gamma (PPAR) expressed in CV-1 cells				J Med Chem 39: 665-8 (1996) Article DOI: 10.1021/jm950395a BindingDB Entry DOI: 10.7270/Q2H9949G
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM28699 (2-(4-chlorophenoxy)-2-methylpropanoic acid | CHEMB...) Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(O)=O Show InChI InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	5.10E+4	n/a	n/a	n/a	n/a
Glaxo Wellcome Research and Development Curated by ChEMBL					Assay Description In vitro transcriptional activaion of peroxisome proliferator activated alpha-receptor (PPAR) expressed in CV-1 cells				J Med Chem 39: 665-8 (1996) Article DOI: 10.1021/jm950395a BindingDB Entry DOI: 10.7270/Q2H9949G
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor gamma (Mus musculus)	BDBM28699 (2-(4-chlorophenoxy)-2-methylpropanoic acid | CHEMB...) Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(O)=O Show InChI InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a
Glaxo Wellcome Research & Development Curated by ChEMBL					Assay Description Compound was tested for its agonist activity against murine Peroxisome proliferator activated receptor gamma-Gal4 chimeric receptor in transfected CV...				J Med Chem 42: 3785-8 (1999) BindingDB Entry DOI: 10.7270/Q29C6WM9
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor (Homo sapiens (Human))	BDBM28699 (2-(4-chlorophenoxy)-2-methylpropanoic acid | CHEMB...) Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(O)=O Show InChI InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a
Glaxo Wellcome Research & Development Curated by ChEMBL					Assay Description Compound was tested for agonist activity on human Peroxisome proliferator activated receptor gamma-Gal4 chimeric receptor in transfected CV-1 cells				J Med Chem 42: 3785-8 (1999) BindingDB Entry DOI: 10.7270/Q29C6WM9
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha) (Homo sapiens (Human))	BDBM28699 (2-(4-chlorophenoxy)-2-methylpropanoic acid | CHEMB...) Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(O)=O Show InChI InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	n/a	n/a	5.50E+4	n/a	n/a	n/a	n/a
Glaxo Wellcome Research & Development Curated by ChEMBL					Assay Description Compound was tested for agonist activity on human Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor in transfected CV-1 cells				J Med Chem 42: 3785-8 (1999) BindingDB Entry DOI: 10.7270/Q29C6WM9
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM28699 (2-(4-chlorophenoxy)-2-methylpropanoic acid | CHEMB...) Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(O)=O Show InChI InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a
Glaxo Wellcome Research & Development Curated by ChEMBL					Assay Description Compound was tested for its agonist activity against murine Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor transfected CV-1 ...				J Med Chem 42: 3785-8 (1999) BindingDB Entry DOI: 10.7270/Q29C6WM9
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor (Homo sapiens (Human))	BDBM28699 (2-(4-chlorophenoxy)-2-methylpropanoic acid | CHEMB...) Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(O)=O Show InChI InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a
University of Chieti "G. d.Annunzio" Curated by ChEMBL					Assay Description Transactivation of GAL4-tagged human PPARalpha LBD expressed in human HepG2 cells at 100 nM to 100 uM incubated for 20 to 22 hrs by luciferase report...				ACS Med Chem Lett 10: 545-551 (2019) Article DOI: 10.1021/acsmedchemlett.8b00574
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (PPAR alpha) (Homo sapiens (Human))	BDBM28699 (2-(4-chlorophenoxy)-2-methylpropanoic acid | CHEMB...) Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(O)=O Show InChI InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	3.96E+4	n/a	n/a	n/a	n/a
Università degli Studi di Milano Curated by ChEMBL					Assay Description Effective concentration against human PPARalpha expressed in HepG2 cells				J Med Chem 48: 5509-19 (2005) Article DOI: 10.1021/jm0502844 BindingDB Entry DOI: 10.7270/Q2PV6JXF
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM28699 (2-(4-chlorophenoxy)-2-methylpropanoic acid | CHEMB...) Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(O)=O Show InChI InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	42	n/a	n/a	n/a	n/a
Università degli Studi di Milano Curated by ChEMBL					Assay Description Effective concentration against murine PPARalpha in transactivation assay				J Med Chem 48: 5509-19 (2005) Article DOI: 10.1021/jm0502844 BindingDB Entry DOI: 10.7270/Q2PV6JXF
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (PPAR alpha) (Homo sapiens (Human))	BDBM28699 (2-(4-chlorophenoxy)-2-methylpropanoic acid | CHEMB...) Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(O)=O Show InChI InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	5.50E+4	n/a	n/a	n/a	n/a
Universit£ degli Studi G. d'Annunzio Curated by ChEMBL					Assay Description Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assay				J Med Chem 52: 6224-32 (2009) Article DOI: 10.1021/jm900878u BindingDB Entry DOI: 10.7270/Q2ZP465F
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (PPAR alpha) (Homo sapiens (Human))	BDBM28699 (2-(4-chlorophenoxy)-2-methylpropanoic acid | CHEMB...) Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(O)=O Show InChI InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	5.50E+4	n/a	n/a	n/a	n/a
Universit£ degli Studi G. d'Annunzio Curated by ChEMBL					Assay Description Agonist activity at PPARalpha ligand binding domain expressed in HEK293 cells co-expressing GAL4 after 18 hrs by dual-luciferase activity based trans...				Bioorg Med Chem Lett 21: 4869-72 (2011) Article DOI: 10.1016/j.bmcl.2011.06.028 BindingDB Entry DOI: 10.7270/Q2DN45F9
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (PPAR alpha) (Homo sapiens (Human))	BDBM28699 (2-(4-chlorophenoxy)-2-methylpropanoic acid | CHEMB...) Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(O)=O Show InChI InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a
Mount Sinai School of Medicine Curated by ChEMBL					Assay Description Activity at PPARalpha				J Med Chem 52: 6931-5 (2009) Article DOI: 10.1021/jm900823s BindingDB Entry DOI: 10.7270/Q2DJ5GJQ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (PPAR alpha) (Homo sapiens (Human))	BDBM28699 (2-(4-chlorophenoxy)-2-methylpropanoic acid | CHEMB...) Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(O)=O Show InChI InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	5.50E+4	n/a	n/a	n/a	n/a
Universit£ degli Studi G. d'Annunzio Curated by ChEMBL					Assay Description Transactivation of human GAL4-fused PPARalpha ligand binding domain transfected in HEK293 cells after 18 hrs by dual luciferase reporter gene assay				Bioorg Med Chem Lett 22: 7662-6 (2012) Article DOI: 10.1016/j.bmcl.2012.09.111 BindingDB Entry DOI: 10.7270/Q2639QW8
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (PPAR alpha) (Homo sapiens (Human))	BDBM28699 (2-(4-chlorophenoxy)-2-methylpropanoic acid | CHEMB...) Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(O)=O Show InChI InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	5.50E+4	n/a	n/a	n/a	n/a
Universit£ G. d'Annunzio Curated by ChEMBL					Assay Description Transactivation of PPARalpha expressed in HEK293A cells co-expressing GAL4 after 16 to 18 hrs by luciferase reporter gene assay				Eur J Med Chem 58: 317-22 (2012) Article DOI: 10.1016/j.ejmech.2012.10.019 BindingDB Entry DOI: 10.7270/Q2CR5VG4
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (PPAR alpha) (Homo sapiens (Human))	BDBM28699 (2-(4-chlorophenoxy)-2-methylpropanoic acid | CHEMB...) Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(O)=O Show InChI InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	5.50E+4	n/a	n/a	n/a	n/a
GSK					Assay Description The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...				J Med Chem 50: 685-95 (2007) Article DOI: 10.1021/jm058056x BindingDB Entry DOI: 10.7270/Q2RN3669
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor (Homo sapiens (Human))	BDBM28699 (2-(4-chlorophenoxy)-2-methylpropanoic acid | CHEMB...) Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(O)=O Show InChI InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.09E+5	n/a	n/a	n/a	n/a
Università degli Studi di Milano Curated by ChEMBL					Assay Description Effective concentration against human PPARgamma expressed in HepG2 cells				J Med Chem 48: 5509-19 (2005) Article DOI: 10.1021/jm0502844 BindingDB Entry DOI: 10.7270/Q2PV6JXF
					More data for this Ligand-Target Pair