Found 39 hits for monomerid = 50001493 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Adenosine receptor A2b
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank PubMed
| 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assay |
Eur J Med Chem 127: 986-996 (2017)
BindingDB Entry DOI: 10.7270/Q2571F7G |
More data for this Ligand-Target Pair | |
Adenosine receptor A2b
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | NCI pathway Reactome pathway KEGG
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| DrugBank PubMed
| 4.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes & Digestive & Kidney Diseases
Curated by ChEMBL
| Assay Description Binding affinity at human Adenosine A2B receptor expressed in HEK-293 cells, using [125I]-ABOPX as radioligand |
J Med Chem 45: 2131-8 (2002)
BindingDB Entry DOI: 10.7270/Q2V1243G |
More data for this Ligand-Target Pair | |
Adenosine receptor A2b
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | NCI pathway Reactome pathway KEGG
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| 4.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CV Therapeutics Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells |
J Med Chem 49: 3682-92 (2006)
Article DOI: 10.1021/jm051268+ BindingDB Entry DOI: 10.7270/Q21V5DMG |
More data for this Ligand-Target Pair | |
Adenosine receptor A2b
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | NCI pathway Reactome pathway KEGG
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| 4.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description Displacement of [3H]DPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrs |
J Med Chem 59: 1967-83 (2016)
BindingDB Entry DOI: 10.7270/Q2QF8VS9 |
More data for this Ligand-Target Pair | |
Adenosine receptor A2b
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | NCI pathway Reactome pathway KEGG
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| DrugBank Article PubMed
| 6.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by PDSP Ki Database
| |
Mol Pharmacol 56: 705-13 (1999)
Article DOI: 10.1016/j.bioorg.2015.09.009 BindingDB Entry DOI: 10.7270/Q2M9077B |
More data for this Ligand-Target Pair | |
Adenosine receptor A2b
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | NCI pathway Reactome pathway KEGG
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| DrugBank Article PubMed
| 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Binding affinity to human adenosine A2B receptor |
J Med Chem 52: 3994-4006 (2009)
Article DOI: 10.1021/jm900413e BindingDB Entry DOI: 10.7270/Q24J0G1M |
More data for this Ligand-Target Pair | |
Adenosine receptor A2b
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | NCI pathway Reactome pathway KEGG
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| 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by PDSP Ki Database
| |
Mol Pharmacol 56: 705-13 (1999)
Article DOI: 10.1016/j.bioorg.2015.09.009 BindingDB Entry DOI: 10.7270/Q2M9077B |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | Reactome pathway KEGG
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| DrugBank Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by PDSP Ki Database
| |
Mol Pharmacol 56: 705-13 (1999)
Article DOI: 10.1016/j.bioorg.2015.09.009 BindingDB Entry DOI: 10.7270/Q2M9077B |
More data for this Ligand-Target Pair | |
Adenosine receptor A2a
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by PDSP Ki Database
| |
Mol Pharmacol 56: 705-13 (1999)
Article DOI: 10.1016/j.bioorg.2015.09.009 BindingDB Entry DOI: 10.7270/Q2M9077B |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB
Reactome pathway KEGG
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by PDSP Ki Database
| |
Mol Pharmacol 56: 705-13 (1999)
Article DOI: 10.1016/j.bioorg.2015.09.009 BindingDB Entry DOI: 10.7270/Q2M9077B |
More data for this Ligand-Target Pair | |
Adenosine receptor A2a
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert/Parke-Davis Pharmaceutical Research
Curated by PDSP Ki Database
| |
Mol Pharmacol 29: 331-46 (1986)
BindingDB Entry DOI: 10.7270/Q2MK6BDV |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB
Reactome pathway KEGG
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert/Parke-Davis Pharmaceutical Research
Curated by PDSP Ki Database
| |
Mol Pharmacol 29: 331-46 (1986)
BindingDB Entry DOI: 10.7270/Q2MK6BDV |
More data for this Ligand-Target Pair | |
Adenosine receptor A2a
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 330: 212-21 (1985)
Article DOI: 10.1007/bf00572436 BindingDB Entry DOI: 10.7270/Q2RB7334 |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB
Reactome pathway KEGG
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 330: 212-21 (1985)
Article DOI: 10.1007/bf00572436 BindingDB Entry DOI: 10.7270/Q2RB7334 |
More data for this Ligand-Target Pair | |
Adenosine A1 receptor
(BOVINE) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB
Reactome pathway KEGG
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 330: 212-21 (1985)
Article DOI: 10.1007/bf00572436 BindingDB Entry DOI: 10.7270/Q2RB7334 |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB
Reactome pathway KEGG
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| 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmazeutische Chemie
Curated by ChEMBL
| Assay Description Binding affinity at Adenosine A1 receptor in rat brain cortical membrane using [3H]-N6-R-phenylisopropyladenosine (R-PIA) as radioligand |
J Med Chem 36: 3341-9 (1993)
BindingDB Entry DOI: 10.7270/Q26Q1W9W |
More data for this Ligand-Target Pair | |
Adenosine receptor A2a
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Binding affinity to human adenosine A2A receptor |
J Med Chem 52: 3994-4006 (2009)
Article DOI: 10.1021/jm900413e BindingDB Entry DOI: 10.7270/Q24J0G1M |
More data for this Ligand-Target Pair | |
Adenosine Receptors A2a (A2a)
(Rattus norvegicus (rat)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Binding affinity to rat adenosine A2A receptor |
J Med Chem 52: 3994-4006 (2009)
Article DOI: 10.1021/jm900413e BindingDB Entry DOI: 10.7270/Q24J0G1M |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB
Reactome pathway KEGG
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| 4.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CV Therapeutics Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]CPX from human adenosine A3 receptor expressed in CHO cells |
J Med Chem 49: 3682-92 (2006)
Article DOI: 10.1021/jm051268+ BindingDB Entry DOI: 10.7270/Q21V5DMG |
More data for this Ligand-Target Pair | |
Phosphodiesterase 4
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB
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| 4.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscle |
J Med Chem 35: 4039-44 (1992)
BindingDB Entry DOI: 10.7270/Q2CF9P23 |
More data for this Ligand-Target Pair | |
Phosphodiesterase 4
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB
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| 4.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of cyclic AMP-phosphodiesterase ( PDE) in the supernatant of tracheal muscle homogenate |
J Med Chem 36: 1380-6 (1993)
BindingDB Entry DOI: 10.7270/Q23B5Z65 |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB
Reactome pathway KEGG
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| 4.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Binding affinity to human adenosine A1 receptor |
J Med Chem 52: 3994-4006 (2009)
Article DOI: 10.1021/jm900413e BindingDB Entry DOI: 10.7270/Q24J0G1M |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB
Reactome pathway KEGG
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| 5.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes
Curated by ChEMBL
| Assay Description Binding affinity for Adenosine A1 receptor from rat brain using [3H]-PIA as radioligand |
J Med Chem 33: 2818-21 (1990)
BindingDB Entry DOI: 10.7270/Q2C53JVQ |
More data for this Ligand-Target Pair | |
Adenosine A1 receptor
(GUINEA PIG) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB
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| 6.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Binding affinity against adenosine A1 receptor of cerebral cortex using [3H]-CPX as a radioligand |
J Med Chem 36: 1380-6 (1993)
BindingDB Entry DOI: 10.7270/Q23B5Z65 |
More data for this Ligand-Target Pair | |
Adenosine A1 receptor
(GUINEA PIG) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB
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| 6.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Affinity against adenosine A1 receptor in the brain membranes by the displacement of [3H]-CPX. |
J Med Chem 35: 4039-44 (1992)
BindingDB Entry DOI: 10.7270/Q2CF9P23 |
More data for this Ligand-Target Pair | |
Adenosine receptor A2a and A3
(Rattus norvegicus) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | Reactome pathway KEGG
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| 6.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Binding affinity to rat adenosine A3 receptor |
J Med Chem 52: 3994-4006 (2009)
Article DOI: 10.1021/jm900413e BindingDB Entry DOI: 10.7270/Q24J0G1M |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB
Reactome pathway KEGG
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| 8.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institutes of Health
Curated by ChEMBL
| Assay Description Inhibition of 1 nM [3H]- N6-(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat cerebral cortical membranes |
J Med Chem 32: 1231-7 (1989)
BindingDB Entry DOI: 10.7270/Q2PZ57T1 |
More data for this Ligand-Target Pair | |
Adenosine receptor A2a
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| DrugBank Article PubMed
| 8.13E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CV Therapeutics Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]ZM241385 from human adenosine A2a receptor expressed in HEK cells |
J Med Chem 49: 3682-92 (2006)
Article DOI: 10.1021/jm051268+ BindingDB Entry DOI: 10.7270/Q21V5DMG |
More data for this Ligand-Target Pair | |
Adenosine A2 receptor
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB
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| 8.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes
Curated by ChEMBL
| Assay Description Antagonism of N-ethylcarboxamido adenosine-stimulated adenylate cyclase associated with stimulation of Adenosine A2 receptor of rat PC12 membranes |
J Med Chem 33: 2818-21 (1990)
BindingDB Entry DOI: 10.7270/Q2C53JVQ |
More data for this Ligand-Target Pair | |
Adenosine A2 receptor
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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| 9.06E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Binding affinity against adenosine A2 receptor of striatal membrane using [3H]CGS-21680 as a radioligand |
J Med Chem 36: 1380-6 (1993)
BindingDB Entry DOI: 10.7270/Q23B5Z65 |
More data for this Ligand-Target Pair | |
Adenosine A2a receptor
(GUINEA PIG) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB MMDB
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| 9.06E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Affinity against adenosine A2 receptor in the brain membranes measured by the displacement of [3H]-CPX |
J Med Chem 35: 4039-44 (1992)
BindingDB Entry DOI: 10.7270/Q2CF9P23 |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | Reactome pathway KEGG
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| DrugBank Article PubMed
| 9.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CV Therapeutics Inc.
Curated by ChEMBL
| Assay Description Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells |
J Med Chem 49: 3682-92 (2006)
Article DOI: 10.1021/jm051268+ BindingDB Entry DOI: 10.7270/Q21V5DMG |
More data for this Ligand-Target Pair | |
Adenosine A2 receptor
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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| 1.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institutes of Health
Curated by ChEMBL
| Assay Description Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via adenosine A2 receptor in human platelet membranes. |
J Med Chem 32: 1231-7 (1989)
BindingDB Entry DOI: 10.7270/Q2PZ57T1 |
More data for this Ligand-Target Pair | |
Adenosine A2 receptor
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB
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| 1.37E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmazeutische Chemie
Curated by ChEMBL
| Assay Description Binding affinity against Adenosine A2 receptor in rat striatal membranes using [3H]5'-(N-ethylcarboxamido)-adenosine (NECA) as the ligand |
J Med Chem 36: 3341-9 (1993)
BindingDB Entry DOI: 10.7270/Q26Q1W9W |
More data for this Ligand-Target Pair | |
Adenosine A2 receptor
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB
UniProtKB/SwissProt
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| 1.37E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes
Curated by ChEMBL
| Assay Description Binding affinity for Adenosine A2 receptor from rat striatum using [3H]NECA as radioligand |
J Med Chem 33: 2818-21 (1990)
BindingDB Entry DOI: 10.7270/Q2C53JVQ |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB
Reactome pathway KEGG
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| 1.56E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Binding affinity to rat adenosine A1 receptor |
J Med Chem 52: 3994-4006 (2009)
Article DOI: 10.1021/jm900413e BindingDB Entry DOI: 10.7270/Q24J0G1M |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | Reactome pathway KEGG
UniProtKB/SwissProt
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| 1.58E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Binding affinity to human adenosine A3 receptor |
J Med Chem 52: 3994-4006 (2009)
Article DOI: 10.1021/jm900413e BindingDB Entry DOI: 10.7270/Q24J0G1M |
More data for this Ligand-Target Pair | |
Bile salt export pump
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB
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| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-... |
Drug Metab Dispos 40: 2332-41 (2012)
Article DOI: 10.1124/dmd.112.047068 BindingDB Entry DOI: 10.7270/Q2ZP488M |
More data for this Ligand-Target Pair | |
Adenosine receptor A2a
(Homo sapiens (Human)) | BDBM50001493
(3-Propyl-3,7-dihydro-purine-2,6-dione | 3-Propyl-3...)Show InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | n/a | n/a | 7.20E+3 | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Relexant activity on the spontaneous tone of isolated guinea pig tracheal ring chains. |
J Med Chem 35: 4039-44 (1992)
BindingDB Entry DOI: 10.7270/Q2CF9P23 |
More data for this Ligand-Target Pair | |