BindingDB PrimarySearch

BDBM50425732 ENZALUTAMIDE::US10053433, FC 4.129::US10806720, Compound Enzalutamide::Xtandi

SMILES: CNC(=O)c1ccc(cc1F)N1C(=S)N(C(=O)C1(C)C)c1ccc(C#N)c(c1)C(F)(F)F

InChI Key: InChIKey=WXCXUHSOUPDCQV-UHFFFAOYSA-N

Data: 5 KI 18 IC50 5 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50425732
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Androgen Receptor (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank Article PubMed	28	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alla Chem LLC Curated by ChEMBL					Assay Description Antagonist activity at androgen receptor (unknown origin)				Eur J Med Chem 99: 51-66 (2015) Article DOI: 10.1016/j.ejmech.2015.05.039 BindingDB Entry DOI: 10.7270/Q2NP265W
Alla Chem LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank Article PubMed	1.35E+3	n/a	2.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
Georgia Institute of Technology					Assay Description A series of dilutions of the compounds were prepared with 10% DMSO in HDAC assay buffer, and 5uL of the dilution was added to a 50uL reaction so that...				ACS Chem Biol 8: 2550-60 (2013) Article DOI: 10.1021/cb400542w BindingDB Entry DOI: 10.7270/Q2CR5S01
Georgia Institute of Technology					More data for this Ligand-Target Pair
Androgen receptor/Baculoviral IAP repeat-containing protein 2 (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank US Patent	3.64E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Tennessee Research Foundation US Patent					Assay Description Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...				US Patent US10806720 (2020)
University of Tennessee Research Foundation US Patent					More data for this Ligand-Target Pair
Androgen receptor/Baculoviral IAP repeat-containing protein 2 (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank Article PubMed	3.64E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Tennessee Health Science Center Curated by ChEMBL					Assay Description Displacement of [3H]-mibolerone from recombinant wild-type GST-tagged androgen receptor LBD (unknown origin) after 16 hrs by scintillation counting a...				J Med Chem 62: 491-511 (2019) Article DOI: 10.1021/acs.jmedchem.8b00973
					More data for this Ligand-Target Pair
Androgen receptor/Baculoviral IAP repeat-containing protein 2 (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank Article PubMed	3.64E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Tennessee Health Science Center Curated by ChEMBL					Assay Description Displacement of [3H]-mibolerone from recombinant wild-type GST-tagged androgen receptor LBD (unknown origin) after 16 hrs by scintillation counting a...				J Med Chem 62: 491-511 (2019) Article DOI: 10.1021/acs.jmedchem.8b00973
					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	915	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Displacement of [3H]R1881 from AR in human LNCaP cells after 2 hrs by scintillation counting analysis				J Med Chem 56: 4880-98 (2013) Article DOI: 10.1021/jm400048v BindingDB Entry DOI: 10.7270/Q2445NWN
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank PubMed	n/a	n/a	361	n/a	n/a	n/a	n/a	n/a	n/a
Cardiff University Curated by ChEMBL					Assay Description Antagonist activity at GAL4 DBD-fused androgen receptor LBD (unknown origin) transfected in UAS-bla GripTite 293 cells assessed as inhibition of R188...				Bioorg Med Chem Lett 26: 3636-40 (2016) BindingDB Entry DOI: 10.7270/Q2571DX1
Cardiff University Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Integral BioSciences Pvt. Ltd Curated by ChEMBL					Assay Description Displacement of [18F]-FDHT from androgen receptor in human LNCAP/AR cells				Bioorg Med Chem Lett 26: 5222-5228 (2016) Article DOI: 10.1016/j.bmcl.2016.09.058 BindingDB Entry DOI: 10.7270/Q29W0HFD
Integral BioSciences Pvt. Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Rattus norvegicus (Rat))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	294	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Medical Science Curated by ChEMBL					Assay Description Displacement of fluormone-DHT green from His/GST-tagged rat AR ligand binding domain after 4 to 8 hrs by fluorescence polarization assay				ACS Med Chem Lett 7: 1024-1027 (2016) Article DOI: 10.1021/acsmedchemlett.6b00180 BindingDB Entry DOI: 10.7270/Q2N58P9K
Chinese Academy of Medical Science Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank US Patent	n/a	n/a	1.94E+3	n/a	n/a	n/a	n/a	7.5	n/a
The Regents of the University of California US Patent					Assay Description Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...				US Patent US10053433 (2018) BindingDB Entry DOI: 10.7270/Q2R78H77
The Regents of the University of California US Patent					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank US Patent	n/a	n/a	8.61E+3	n/a	n/a	n/a	n/a	7.5	n/a
The Regents of the University of California US Patent					Assay Description An AR-response element is contained within the mmTV sequence and drives the expression of luciferase. The effect of antiandrogens (competitive antago...				US Patent US10053433 (2018) BindingDB Entry DOI: 10.7270/Q2R78H77
The Regents of the University of California US Patent					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	420	n/a	n/a	n/a	n/a
Drexel University College of Medicine Curated by ChEMBL					Assay Description Antagonist activity at full length human androgen receptor expressed in mammalian expression system measured after 22 to 24 hrs by luciferase reporte...				Bioorg Med Chem Lett 27: 2216-2220 (2017) Article DOI: 10.1016/j.bmcl.2017.03.030 BindingDB Entry DOI: 10.7270/Q2P84F1X
Drexel University College of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank Article PubMed	n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Antagonist activity at androgen receptor (unknown origin) expressed in African green monkey COS7 cells assessed as inhibition of R1881-induced protei...				Eur J Med Chem 143: 1325-1344 (2018) Article DOI: 10.1016/j.ejmech.2017.10.031 BindingDB Entry DOI: 10.7270/Q25M6873
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Vancouver Prostate Centre (VPC) Curated by ChEMBL					Assay Description Inhibition of full length AR transcriptional activity in human LNCAP cells harboring AR2PB-eGFP construct assessed as reduction in R1881-induced secr...				Eur J Med Chem 157: 1164-1173 (2018) Article DOI: 10.1016/j.ejmech.2018.08.059 BindingDB Entry DOI: 10.7270/Q2183967
Vancouver Prostate Centre (VPC) Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Vancouver Prostate Centre (VPC) Curated by ChEMBL					Assay Description Inhibition of R1881-induced full length AR transcriptional activity in human LNCAP cells harboring AR2PB-eGFP construct after 72 hrs by fluorescence ...				Eur J Med Chem 157: 1164-1173 (2018) Article DOI: 10.1016/j.ejmech.2018.08.059 BindingDB Entry DOI: 10.7270/Q2183967
Vancouver Prostate Centre (VPC) Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen Receptor (Rattus norvegicus (Rat))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
Southern Medical University Curated by ChEMBL					Assay Description Displacement of fluormone-AL Green from His-tagged/GST-fused recombinant rat androgen receptor LBD expressed in insect cells measured after 4 hrs by ...				Bioorg Med Chem 27: 133-143 (2019) Article DOI: 10.1016/j.bmc.2018.11.029
Southern Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor/Baculoviral IAP repeat-containing protein 2 (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	180	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Inhibition of DHT-induced androgen receptor transactivation in human LNCaP cells after 24 hrs by luciferase reporter gene assay relative to control				ACS Med Chem Lett 7: 708-13 (2016) Article DOI: 10.1021/acsmedchemlett.6b00137
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor/Baculoviral IAP repeat-containing protein 2 (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank Article PubMed	n/a	n/a	5.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University and Collaborative Innovation Center for Biotherapy Curated by ChEMBL					Assay Description Competitive displacement of [3H]R1881 from human AR-LBD expressed in LNCaP cells incubated for 24 hrs by scintillation counting method based radiolig...				Eur J Med Chem 171: 265-281 (2019) Article DOI: 10.1016/j.ejmech.2019.03.041
					More data for this Ligand-Target Pair
Androgen receptor/Baculoviral IAP repeat-containing protein 2 (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Antagonist activity at androgen receptor in human C4-2-PSA-rl cells incubated for 24 hrs in presence of androgen R1881 by dual-glo luciferase reporte...				ACS Med Chem Lett 7: 785-90 (2016) Article DOI: 10.1021/acsmedchemlett.6b00186
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen Receptor (Rattus norvegicus (Rat))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	361	n/a	n/a	n/a	n/a	n/a	n/a
School of Pharmacy and Pharmaceutical Sciences Curated by ChEMBL					Assay Description Antagonist activity at rat androgen receptor fused with DNA-binding domain of GAL4 expressed in AR-UAS-bla GripTite 293 cells assessed as inhibition ...				Eur J Med Chem 118: 230-43 (2016) Article DOI: 10.1016/j.ejmech.2016.04.052
					More data for this Ligand-Target Pair
Androgen Receptor (Rattus norvegicus (Rat))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
Luoyang Normal University Curated by ChEMBL					Assay Description Displacement of fluormone-AL Green from His-tagged/GST-fused recombinant rat androgen receptor LBD expressed in insect cells measured after 4 hrs by ...				Bioorg Med Chem 27: (2019) Article DOI: 10.1016/j.bmc.2019.115081
Luoyang Normal University Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor/Baculoviral IAP repeat-containing protein 2 (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank Article PubMed	n/a	n/a	216	n/a	n/a	n/a	n/a	n/a	n/a
University of Tennessee Health Science Center Curated by ChEMBL					Assay Description Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of R1881-induced receptor transactivation after 24 hr...				J Med Chem 62: 491-511 (2019) Article DOI: 10.1021/acs.jmedchem.8b00973
					More data for this Ligand-Target Pair
Androgen receptor/Baculoviral IAP repeat-containing protein 2 (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank US Patent	n/a	n/a	216	n/a	n/a	n/a	n/a	n/a	n/a
University of Tennessee Research Foundation US Patent					Assay Description Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...				US Patent US10806720 (2020)
University of Tennessee Research Foundation US Patent					More data for this Ligand-Target Pair
Androgen receptor/Baculoviral IAP repeat-containing protein 2 (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank Article PubMed	n/a	n/a	216	n/a	n/a	n/a	n/a	n/a	n/a
University of Tennessee Health Science Center Curated by ChEMBL					Assay Description Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of R1881-induced receptor transactivation after 24 hr...				J Med Chem 62: 491-511 (2019) Article DOI: 10.1021/acs.jmedchem.8b00973
					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	49	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Displacement of [3H]R1881 from AR in human MDA-MB-453 cells				J Med Chem 56: 4880-98 (2013) Article DOI: 10.1021/jm400048v BindingDB Entry DOI: 10.7270/Q2445NWN
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank Article PubMed	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
SAIC Frederick, Inc. Curated by ChEMBL					Assay Description Displacement of Fluormone AL Green from androgen receptor ligand binding domain (unknown origin) after 4 hrs by fluorescence polarization assay				J Med Chem 56: 8280-97 (2013) Article DOI: 10.1021/jm301714s BindingDB Entry DOI: 10.7270/Q2FF3TTZ
SAIC Frederick, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM50425732 (ENZALUTAMIDE \| US10053433, FC 4.129 \| US10806720, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of British Columbia Curated by ChEMBL					Assay Description Inhibition of BF3 site of androgen receptor in enzalutamide-resistant human LNCAP cells assessed as reduction in PSA level after 3 days				J Med Chem 56: 1136-48 (2013) Article DOI: 10.1021/jm3015712 BindingDB Entry DOI: 10.7270/Q2ZW1N7N
University of British Columbia Curated by ChEMBL					More data for this Ligand-Target Pair