Found 36 hits for monomerid = 50074922 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclooxygenase-1 (COX-1)
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB
UniProtKB/SwissProt
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| PDB Article PubMed
| 75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 96: 7563-8 (1999)
Article DOI: 10.1073/pnas.96.13.7563 BindingDB Entry DOI: 10.7270/Q21G0JT4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclooxygenase-1 (COX-1)
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB
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| PDB Article PubMed
| 410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
| |
Am J Med 104: 413-21 (1998)
Article DOI: 10.1016/s0002-9343(98)00091-6 BindingDB Entry DOI: 10.7270/Q2F18X97 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclooxygenase
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| DrugBank PDB Article PubMed
| 770 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 96: 7563-8 (1999)
Article DOI: 10.1073/pnas.96.13.7563 BindingDB Entry DOI: 10.7270/Q21G0JT4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Prostaglandin G/H synthase (cyclooxygenase)
(Ovis aries (Sheep)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB
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| PDB PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Drexel University College of Medicine
Curated by ChEMBL
| Assay Description Binding affinity of compound towards prostaglandin G/H synthase 1 was evaluated |
Bioorg Med Chem Lett 14: 667-71 (2004)
BindingDB Entry DOI: 10.7270/Q2N29WC9 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Liver fatty acid binding protein (rat L-FABP)
(Rattus norvegicus (Rat)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB MMDB
Reactome pathway KEGG
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| 1.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by co... |
J Med Chem 51: 3755-64 (2008)
Article DOI: 10.1021/jm701192w BindingDB Entry DOI: 10.7270/Q2KH0P7G |
More data for this Ligand-Target Pair | |
Cyclooxygenase
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| DrugBank PDB Article PubMed
| 4.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
| |
Am J Med 104: 413-21 (1998)
Article DOI: 10.1016/s0002-9343(98)00091-6 BindingDB Entry DOI: 10.7270/Q2F18X97 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclooxygenase
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| DrugBank PDB Article PubMed
| 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 96: 7563-8 (1999)
Article DOI: 10.1073/pnas.96.13.7563 BindingDB Entry DOI: 10.7270/Q21G0JT4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Intestinal fatty acid-binding protein (hIFABP)
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB
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| 2.32E+4 | -12.0 | n/a | n/a | n/a | n/a | n/a | n/a | 293.15 |
Monash University
| Assay Description Briefly, steady-state fluorescence spectra of ANS binding was monitored by measuring the increase in fluorescence signal between 450?550 nm following... |
ACS Chem Biol 9: 2526-34 (2014)
Article DOI: 10.1021/cb5005178 BindingDB Entry DOI: 10.7270/Q2348J4C |
More data for this Ligand-Target Pair | |
Intestinal fatty acid-binding protein (hIFABP)
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB
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| 2.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description Displacement of 1-anilinonaphthalene-8-sulphonic acid from I-FABP |
J Med Chem 51: 3755-64 (2008)
Article DOI: 10.1021/jm701192w BindingDB Entry DOI: 10.7270/Q2KH0P7G |
More data for this Ligand-Target Pair | |
Liver fatty acid binding protein (rat L-FABP)
(Rattus norvegicus (Rat)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB MMDB
Reactome pathway KEGG
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| 2.22E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP low binding affinity site expressed in Escherichia coli BL21 by com... |
J Med Chem 51: 3755-64 (2008)
Article DOI: 10.1021/jm701192w BindingDB Entry DOI: 10.7270/Q2KH0P7G |
More data for this Ligand-Target Pair | |
Serum albumin
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| DrugBank Article PubMed
| 1.00E+14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Molecular Discovery Ltd.
Curated by ChEMBL
| Assay Description Binding affinity towards human serum albumin |
J Med Chem 48: 2469-79 (2005)
Article DOI: 10.1021/jm049227l BindingDB Entry DOI: 10.7270/Q2125WDN |
More data for this Ligand-Target Pair | |
17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3)
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 1.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal His6-tagged AKR1C3 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-1... |
J Med Chem 55: 7746-58 (2012)
Article DOI: 10.1021/jm3007867 BindingDB Entry DOI: 10.7270/Q28K7B6F |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Solute carrier family 22 member 6
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | Reactome pathway KEGG
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| DrugBank PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cells |
J Pharmacol Exp Ther 295: 10-5 (2000)
BindingDB Entry DOI: 10.7270/Q2TB186W |
More data for this Ligand-Target Pair | |
Cyclooxygenase-2 (COX-2)
(Mus musculus (Mouse)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB
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| PDB Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
King's College London
Curated by ChEMBL
| Assay Description Inhibition of mouse COX2 |
Bioorg Med Chem 18: 2204-18 (2010)
Article DOI: 10.1016/j.bmc.2010.01.070 BindingDB Entry DOI: 10.7270/Q27945MJ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Prostaglandin G/H synthase (cyclooxygenase)
(Ovis aries (Sheep)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB
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| PDB Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
King's College London
Curated by ChEMBL
| Assay Description Inhibition of ovine COX1 |
Bioorg Med Chem 18: 2204-18 (2010)
Article DOI: 10.1016/j.bmc.2010.01.070 BindingDB Entry DOI: 10.7270/Q27945MJ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Prostaglandin G/H synthase (cyclooxygenase)
(Ovis aries (Sheep)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB
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| PDB PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Drexel University College of Medicine
Curated by ChEMBL
| Assay Description Reverisible competitive inhibition of prostaglandin G/H synthase 1 |
Bioorg Med Chem Lett 14: 667-71 (2004)
BindingDB Entry DOI: 10.7270/Q2N29WC9 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclooxygenase-1 (COX-1)
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB
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| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wroclaw Medical University
Curated by ChEMBL
| Assay Description Inhibition of COX-1 (unknown origin) |
Bioorg Med Chem 25: 316-326 (2017)
Article DOI: 10.1016/j.bmc.2016.10.036 BindingDB Entry DOI: 10.7270/Q21V5GZS |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclooxygenase
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| DrugBank PDB Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wroclaw Medical University
Curated by ChEMBL
| Assay Description Inhibition of COX-2 (unknown origin) |
Bioorg Med Chem 25: 316-326 (2017)
Article DOI: 10.1016/j.bmc.2016.10.036 BindingDB Entry DOI: 10.7270/Q21V5GZS |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Fondazione Istituto Italiano Di Tecnologia; The Regents of the University of California; Alma Mater Studiorum—Universita' Di Bologna
US Patent
| Assay Description Human recombinant FAAH was obtained from a HEK-293 FAAH-1 overexpressing stable cell line. Cells were grown in DMEM medium containing 10% FBS, 1% pen... |
US Patent US9630914 (2017)
BindingDB Entry DOI: 10.7270/Q2JW8H0S |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase (cyclooxygenase)
(Ovis aries (Sheep)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB
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| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Fondazione Istituto Italiano Di Tecnologia; The Regents of the University of California; Alma Mater Studiorum—Universita' Di Bologna
US Patent
| Assay Description COX activity was measured using a commercial kit (COX Inhibitor Screening Assay Kit Cayman Chemical N. 560131) which includes both ovine COX-1 and hu... |
US Patent US9630914 (2017)
BindingDB Entry DOI: 10.7270/Q2JW8H0S |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Prostaglandin E synthase/G/H synthase 2
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | 1.04E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Fondazione Istituto Italiano Di Tecnologia; The Regents of the University of California; Alma Mater Studiorum—Universita' Di Bologna
US Patent
| Assay Description COX activity was measured using a commercial kit (COX Inhibitor Screening Assay Kit Cayman Chemical N. 560131) which includes both ovine COX-1 and hu... |
US Patent US9630914 (2017)
BindingDB Entry DOI: 10.7270/Q2JW8H0S |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Bile salt export pump
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB
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| Article PubMed
| n/a | n/a | 7.25E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in rats |
Drug Metab Dispos 40: 2332-41 (2012)
Article DOI: 10.1124/dmd.112.047068 BindingDB Entry DOI: 10.7270/Q2ZP488M |
More data for this Ligand-Target Pair | |
Acid-sensing ion channel 1
(Rattus norvegicus) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB
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| Article PubMed
| n/a | n/a | 1.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp |
J Med Chem 60: 8192-8200 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV |
More data for this Ligand-Target Pair | |
Amiloride-sensitive cation channel 3
(Rattus norvegicus) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
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| Article PubMed
| n/a | n/a | 2.29E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clamp |
J Med Chem 60: 8192-8200 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV |
More data for this Ligand-Target Pair | |
Aldo-keto reductase family 1 member C2
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| PDB Article PubMed
| n/a | n/a | 3.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal His6-tagged AKR1C2 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-1... |
J Med Chem 55: 7746-58 (2012)
Article DOI: 10.1021/jm3007867 BindingDB Entry DOI: 10.7270/Q28K7B6F |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aldo-keto reductase family 1 member C4 (AK1C4)
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal His6-tagged AKR1C4 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-1... |
J Med Chem 55: 7746-58 (2012)
Article DOI: 10.1021/jm3007867 BindingDB Entry DOI: 10.7270/Q28K7B6F |
More data for this Ligand-Target Pair | |
Cyclooxygenase
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank PDB PubMed
| n/a | n/a | 1.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Fondazione Istituto Italiano di Tecnologia
Curated by ChEMBL
| Assay Description Inhibition of recombinant human COX2 assessed as production of PGF2-alpha preincubated with compound followed by the addition of 5 uM arachidonic aci... |
Eur J Med Chem 109: 216-37 (2016)
BindingDB Entry DOI: 10.7270/Q21C1ZRJ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Prostaglandin G/H synthase (cyclooxygenase)
(Ovis aries (Sheep)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB
KEGG
UniProtKB/SwissProt
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| PDB PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Fondazione Istituto Italiano di Tecnologia
Curated by ChEMBL
| Assay Description Inhibition of ovine COX1 assessed as production of PGF2-alpha preincubated with compound followed by the addition of 5 uM arachidonic acid as substra... |
Eur J Med Chem 109: 216-37 (2016)
BindingDB Entry DOI: 10.7270/Q21C1ZRJ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Fatty-acid amide hydrolase 1 (aa 30-579)
(Rattus norvegicus (rat)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB MMDB
UniProtKB/SwissProt
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Fondazione Istituto Italiano di Tecnologia
Curated by ChEMBL
| Assay Description Inhibition of FAAH in Sprague-Dawley rat brain homogenates preincubated for 10 mins followed by addition of substrate measured after 30 mins by liqui... |
Eur J Med Chem 109: 216-37 (2016)
BindingDB Entry DOI: 10.7270/Q21C1ZRJ |
More data for this Ligand-Target Pair | |
Cyclooxygenase
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank PDB Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Chemical Biology and Center in Molecular Toxicology
Curated by ChEMBL
| Assay Description Inhibition of COX2 |
J Med Chem 50: 1425-41 (2007)
Article DOI: 10.1021/jm0613166 BindingDB Entry DOI: 10.7270/Q2P26XTQ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
COX-1
(RAT) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB MMDB
UniProtKB/SwissProt
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| PDB Article PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Concentration required to inhibit cyclooxygenase-1 in rat blood |
J Med Chem 48: 5705-20 (2005)
Article DOI: 10.1021/jm0502541 BindingDB Entry DOI: 10.7270/Q2CC106W |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta amyloid A4 protein
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| n/a | n/a | 3.05E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL) |
J Med Chem 48: 5705-20 (2005)
Article DOI: 10.1021/jm0502541 BindingDB Entry DOI: 10.7270/Q2CC106W |
More data for this Ligand-Target Pair | |
Cyclooxygenase-1 (COX-1)
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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| PDB Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Chemical Biology and Center in Molecular Toxicology
Curated by ChEMBL
| Assay Description Inhibition of COX1 |
J Med Chem 50: 1425-41 (2007)
Article DOI: 10.1021/jm0613166 BindingDB Entry DOI: 10.7270/Q2P26XTQ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclooxygenase
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Canada Inc.
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against Prostaglandin G/H synthase 2 (COX-2) in human |
Bioorg Med Chem Lett 9: 307-12 (1999)
BindingDB Entry DOI: 10.7270/Q2H994CC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Prostaglandin G/H synthase (cyclooxygenase)
(Ovis aries (Sheep)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB
KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
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| PDB PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Canada Inc.
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against Prostaglandin G/H synthase 1 in sheep |
Bioorg Med Chem Lett 9: 307-12 (1999)
BindingDB Entry DOI: 10.7270/Q2H994CC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aldo-keto reductase family 1 member C1
(Homo sapiens (Human)) | BDBM50074922
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal His6-tagged AKR1C1 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-1... |
J Med Chem 55: 7746-58 (2012)
Article DOI: 10.1021/jm3007867 BindingDB Entry DOI: 10.7270/Q28K7B6F |
More data for this Ligand-Target Pair | 3D Structure (crystal) |