BDBM50011181 (PFA)dihydroxyphosphinecarboxylic acid oxide::CHEMBL666::FOSCARNET::Forscarnet::Foscarnet (PFA)::Foscavir::Phosphono-formic acid(PFA)::Phosphonoformate::dihydroxyphosphinecarboxylic acid oxide::dihydroxyphosphinecarboxylic acid oxide(PFA)::phosphonoformic acid(PFA)

SMILES: OC(=O)P(O)(O)=O

InChI Key: InChIKey=ZJAOAACCNHFJAH-UHFFFAOYSA-N

Data: 4 KI  14 IC50  2 Kd

PDB links: 8 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50011181   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Carbonic anhydrase 4 (Homo sapiens (Human))	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.20E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Université Montpellier II Curated by ChEMBL					Assay Description Binding affinity towards human membrane associated carbonic anhydrase IV				Bioorg Med Chem Lett 15: 1683-6 (2005) Article DOI: 10.1016/j.bmcl.2005.01.049 BindingDB Entry DOI: 10.7270/Q2NC60PJ
					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2.21E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Université Montpellier II Curated by ChEMBL					Assay Description Binding affinity owards recombinant human transmembrane carbonic anhydrase IX				Bioorg Med Chem Lett 15: 1683-6 (2005) Article DOI: 10.1016/j.bmcl.2005.01.049 BindingDB Entry DOI: 10.7270/Q2NC60PJ
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.42E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Université Montpellier II Curated by ChEMBL					Assay Description Binding affinity towards human cytosolic carbonic anhydrase II				Bioorg Med Chem Lett 15: 1683-6 (2005) Article DOI: 10.1016/j.bmcl.2005.01.049 BindingDB Entry DOI: 10.7270/Q2NC60PJ
					More data for this Ligand-Target Pair
Carbonic Anhydrase VA (Homo sapiens (Human))	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	4.17E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Université Montpellier II Curated by ChEMBL					Assay Description Binding affinity towards recombinant human mitochondrial carbonic anhydrase V				Bioorg Med Chem Lett 15: 1683-6 (2005) Article DOI: 10.1016/j.bmcl.2005.01.049 BindingDB Entry DOI: 10.7270/Q2NC60PJ
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase E89T mutant assessed as inhibition of DNA primer extension using [8-3H(N)]-dATP by scintillation p...				J Med Chem 57: 7435-49 (2014) Article DOI: 10.1021/jm501010f BindingDB Entry DOI: 10.7270/Q20R9R32
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase M184V mutant assessed as inhibition of DNA primer extension using [8-3H(N)]-dATP by scintillation ...				J Med Chem 57: 7435-49 (2014) Article DOI: 10.1021/jm501010f BindingDB Entry DOI: 10.7270/Q20R9R32
					More data for this Ligand-Target Pair
DNA polymerase alpha subunit (Homo sapiens (Human))	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	7.5	n/a
Pharmacia Corporation Curated by ChEMBL					Assay Description Inhibition of human alpha DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C...				J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39
					More data for this Ligand-Target Pair
DNA polymerase (Human cytomegalovirus (HCMV strain AD169) )	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	7.5	n/a
Pharmacia Corporation Curated by ChEMBL					Assay Description Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 d...				J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39
					More data for this Ligand-Target Pair
DNA polymerase delta subunit 1 (Homo sapiens (Human))	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	7.5	n/a
Pharmacia Corporation Curated by ChEMBL					Assay Description Inhibition of human delta DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C...				J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39
					More data for this Ligand-Target Pair
DNA polymerase (Varicella-zoster virus (strain Dumas) (HHV-3) (Hum...)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	<280	n/a	n/a	n/a	n/a	7.5	n/a
Pharmacia Corporation Curated by ChEMBL					Assay Description Inhibition of Varicella-Zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 ...				J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39
					More data for this Ligand-Target Pair
DNA polymerase (Human cytomegalovirus (HCMV strain AD169) )	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of HCMV DNA polymerase by scintillation proximity assay				Bioorg Med Chem Lett 17: 3349-53 (2007) Article DOI: 10.1016/j.bmcl.2007.03.102 BindingDB Entry DOI: 10.7270/Q2HX1DHN
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase p66/p51 polymerase using PPT57 DNA/Cy5-labeled PPT24 as template/primer preincubated for 10 mins followed by...				Bioorg Med Chem 26: 1713-1726 (2018) Article DOI: 10.1016/j.bmc.2018.02.017 BindingDB Entry DOI: 10.7270/Q270842C
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Binding affinity to HIV1 reverse transcriptase p66/p51-polypurine tract primer complex in presence of Mg2+ ions by band shift assay				J Biol Chem 282: 3337-46 (2007) Article DOI: 10.1074/jbc.m607710200 BindingDB Entry DOI: 10.7270/Q2T43WW0
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	1.39E+4	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Binding affinity to HIV1 reverse transcriptase p66/p51-polypurine tract primer complex in absence of Mg2+ ions by band shift assay				J Biol Chem 282: 3337-46 (2007) Article DOI: 10.1074/jbc.m607710200 BindingDB Entry DOI: 10.7270/Q2T43WW0
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of HIV1 RT mediated DNA-dependent DNA synthesis initiation using RNA/DNAM duplex primed substrate by scintillation proximity assay				J Biol Chem 282: 8005-10 (2007) Article DOI: 10.1074/jbc.m608274200 BindingDB Entry DOI: 10.7270/Q2PG1VH3
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase K65R mutant assessed as inhibition of DNA primer extension using [8-3H(N)]-dATP by scintillation p...				J Med Chem 57: 7435-49 (2014) Article DOI: 10.1021/jm501010f BindingDB Entry DOI: 10.7270/Q20R9R32
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as inhibition of DNA primer extension using [8-3H(N)]-dATP by scintillation proximity ass...				J Med Chem 57: 7435-49 (2014) Article DOI: 10.1021/jm501010f BindingDB Entry DOI: 10.7270/Q20R9R32
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of HIV1 RT mediated DNA-dependent DNA synthesis initiation using RNA PPT primed substrate by scintillation proximity assay				J Biol Chem 282: 8005-10 (2007) Article DOI: 10.1074/jbc.m608274200 BindingDB Entry DOI: 10.7270/Q2PG1VH3
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Química Médica (C.S.I.C.) Curated by ChEMBL					Assay Description Inhibitory concentration against wild type HIV-1 reverse transcriptase (RT) using poly rC.dG as the template or primer				J Med Chem 47: 3418-26 (2004) Article DOI: 10.1021/jm031045o BindingDB Entry DOI: 10.7270/Q2B857KW
					More data for this Ligand-Target Pair				3D Structure (crystal)
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	5.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Química Médica (C.S.I.C.) Curated by ChEMBL					Assay Description Inhibitory concentration against wild type HIV-1/138Lys reverse transcriptase (RT) using [3H]dGTP as a radioligand				J Med Chem 47: 3418-26 (2004) Article DOI: 10.1021/jm031045o BindingDB Entry DOI: 10.7270/Q2B857KW
					More data for this Ligand-Target Pair				3D Structure (crystal)