BDBM18122 (4S)-4-amino-5-[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}sulfonyl)amino]-5-oxopentanoic acid::5-O-[N-(L-Glutamyl)-sulfamoyl]adenosine 5::Glu-AMS
SMILES: N[C@@H](CCC(O)=O)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
InChI Key: InChIKey=YBRKRYFZKHICLS-WERHYGNASA-N
Data: 2 KI
PDB links: 7 PDB IDs match this monomer. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
tRNA synthetase (GluRS) (Escherichia coli) | BDBM18122 ((4S)-4-amino-5-[({[(2R,3S,4R,5R)-5-(6-amino-9H-pur...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 2.80 | -12.1 | n/a | n/a | n/a | n/a | n/a | 7.2 | 37 |
CREFSIP | Assay Description The Km and Kappm for the amino acid substrate were first calculated from Lineweaver-Burk plots. The Ki values were calculated from the Kappm vs [I] p... | J Enzyme Inhib Med Chem 20: 61-7 (2005) Article DOI: 10.1080/14756360400002007 BindingDB Entry DOI: 10.7270/Q2X0659C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
tRNA synthetase (GluRS) (Mus musculus (mouse)) | BDBM18122 ((4S)-4-amino-5-[({[(2R,3S,4R,5R)-5-(6-amino-9H-pur...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 70 | -9.92 | n/a | n/a | n/a | n/a | n/a | 8.0 | 30 |
CREFSIP | Assay Description The Km and Kappm for the amino acid substrate were first calculated from Lineweaver-Burk plots. The Ki values were calculated from the Kappm vs [I] p... | J Enzyme Inhib Med Chem 20: 61-7 (2005) Article DOI: 10.1080/14756360400002007 BindingDB Entry DOI: 10.7270/Q2X0659C | |||||||||||
More data for this Ligand-Target Pair |