BindingDB PrimarySearch

BDBM50403371 Firazyr::HOE-140::ICATIBANT

SMILES: [#7]-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-1-[#6]-[#6@H](-[#8])-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1cccs1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-1-[#6]-c2ccccc2-[#6]-[#6@@H]-1-[#6](=O)-[#7]-1-[#6@H]-2-[#6]-[#6]-[#6]-[#6]-[#6@H]-2-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](-[#8])=O

InChI Key: InChIKey=QURWXBZNHXJZBE-SKXRKSCCSA-N

Data: 3 KI 9 IC50 3 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50403371
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
BDKRB2 (Homo sapiens (Human))	BDBM50403371 (Firazyr \| HOE-140 \| ICATIBANT) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	PubMed	0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£s Montpellier I et II Curated by ChEMBL					Assay Description Binding affinity towards human cloned Bradykinin receptor B2 expressed in CHO cells by [3H]bradykinin displacement.				J Med Chem 42: 4193-201 (1999) BindingDB Entry DOI: 10.7270/Q2222VFV
Universit£s Montpellier I et II Curated by ChEMBL					More data for this Ligand-Target Pair
BDKRB2 (Homo sapiens (Human))	BDBM50403371 (Firazyr \| HOE-140 \| ICATIBANT) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	PubMed	0.0640	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£s Montpellier I et II Curated by ChEMBL					Assay Description Binding affinity against human cloned Bradykinin receptor B2 expressed in CHO cells using [3H]-bradykinin as radioligand				J Med Chem 42: 4185-92 (1999) BindingDB Entry DOI: 10.7270/Q25Q4WTF
Universit£s Montpellier I et II Curated by ChEMBL					More data for this Ligand-Target Pair
BDKRB2 (RAT)	BDBM50403371 (Firazyr \| HOE-140 \| ICATIBANT) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	PubMed	0.0770	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£s Montpellier I et II Curated by ChEMBL					Assay Description Binding affinity against rat bradykinin B2 receptors expressed in CHO cells using [3H]bradykinin as radioligand				J Med Chem 42: 4185-92 (1999) BindingDB Entry DOI: 10.7270/Q25Q4WTF
Universit£s Montpellier I et II Curated by ChEMBL					More data for this Ligand-Target Pair
BDKRB2 (Homo sapiens (Human))	BDBM50403371 (Firazyr \| HOE-140 \| ICATIBANT) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.490	n/a	n/a	n/a	n/a	n/a	n/a
Fujisawa Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition specific binding of [3H]BK (1.0 nM) to human Bradykinin receptor B2 which was expressed in CHO (Chinese hamster ovary) cells by 50%.				J Med Chem 41: 4062-79 (1998) Article DOI: 10.1021/jm980300f BindingDB Entry DOI: 10.7270/Q2RX9CS1
Fujisawa Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
BDKRB2 (Homo sapiens (Human))	BDBM50403371 (Firazyr \| HOE-140 \| ICATIBANT) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.490	n/a	n/a	n/a	n/a	n/a	n/a
Fujisawa Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description In vitro inhibitory activity towards human bradykinin receptor B2 expressed in CHO cells using [3H]BK (1.0 nM) as a radioligand				J Med Chem 47: 1617-30 (2004) Article DOI: 10.1021/jm030159x BindingDB Entry DOI: 10.7270/Q2P55P89
Fujisawa Pharmaceutical Co. Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
BDKRB2 (Homo sapiens (Human))	BDBM50403371 (Firazyr \| HOE-140 \| ICATIBANT) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0900	n/a	n/a	n/a	n/a	n/a	n/a
Fujisawa Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description In vitro inhibitory activity towards bradykinin receptor B2 using [3H]BK (0.06 nM) as a radioligand in guinea pig ileum membrane preparation				J Med Chem 47: 1617-30 (2004) Article DOI: 10.1021/jm030159x BindingDB Entry DOI: 10.7270/Q2P55P89
Fujisawa Pharmaceutical Co. Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
BDKRB2 (Homo sapiens (Human))	BDBM50403371 (Firazyr \| HOE-140 \| ICATIBANT) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	0.282	n/a	n/a	n/a	n/a	n/a
University of Firenze and CNR-ICCOM Curated by ChEMBL					Assay Description Antagonist activity against bradykinin B2 receptor				Bioorg Med Chem Lett 16: 2387-90 (2006) Article DOI: 10.1016/j.bmcl.2006.01.125 BindingDB Entry DOI: 10.7270/Q2RN3936
University of Firenze and CNR-ICCOM Curated by ChEMBL					More data for this Ligand-Target Pair
BDKRB2 (RAT)	BDBM50403371 (Firazyr \| HOE-140 \| ICATIBANT) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	0.316	n/a	n/a	n/a	n/a	n/a
Cortech, Inc. Curated by ChEMBL					Assay Description In vitro Bradykinin receptor B2 antagonist activity by using rat uterus functional assay				J Med Chem 39: 1472-84 (1996) Article DOI: 10.1021/jm950716i BindingDB Entry DOI: 10.7270/Q2HQ413S
Cortech, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
BDKRB2 (Homo sapiens (Human))	BDBM50403371 (Firazyr \| HOE-140 \| ICATIBANT) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article	n/a	n/a	n/a	0.912	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist effect against bradykinin B2 receptor was determined in rabbit jugular vein				Bioorg Med Chem Lett 4: 781-784 (1994) Article DOI: 10.1016/S0960-894X(01)80847-7 BindingDB Entry DOI: 10.7270/Q2NP25KV
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
BDKRB2 (Homo sapiens (Human))	BDBM50403371 (Firazyr \| HOE-140 \| ICATIBANT) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0900	n/a	n/a	n/a	n/a	n/a	n/a
Fujisawa Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.				J Med Chem 41: 4053-61 (1998) Article DOI: 10.1021/jm980214f BindingDB Entry DOI: 10.7270/Q2WQ04GV
Fujisawa Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
BDKRB2 (Homo sapiens (Human))	BDBM50403371 (Firazyr \| HOE-140 \| ICATIBANT) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0900	n/a	n/a	n/a	n/a	n/a	n/a
Fujisawa Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Concentration required to inhibit specific binding of [ 3H]BK (0.06 nM) to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.				J Med Chem 41: 4062-79 (1998) Article DOI: 10.1021/jm980300f BindingDB Entry DOI: 10.7270/Q2RX9CS1
Fujisawa Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Bradykinin B2 receptor (Cavia porcellus)	BDBM50403371 (Firazyr \| HOE-140 \| ICATIBANT) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0900	n/a	n/a	n/a	n/a	n/a	n/a
Fujisawa Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Concentration required to inhibit specific binding of [ 3H]BK (0.06 nM) to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.				J Med Chem 41: 4062-79 (1998) Article DOI: 10.1021/jm980300f BindingDB Entry DOI: 10.7270/Q2RX9CS1
Fujisawa Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Bradykinin B2 receptor (Cavia porcellus)	BDBM50403371 (Firazyr \| HOE-140 \| ICATIBANT) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0900	n/a	n/a	n/a	n/a	n/a	n/a
Fujisawa Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.				J Med Chem 41: 4053-61 (1998) Article DOI: 10.1021/jm980214f BindingDB Entry DOI: 10.7270/Q2WQ04GV
Fujisawa Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Bradykinin B2 receptor (Cavia porcellus)	BDBM50403371 (Firazyr \| HOE-140 \| ICATIBANT) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Zentrale Pharmaforschung Curated by ChEMBL					Assay Description In vitro antagonistic activity for Bradykinin receptor B2 by guinea pig ileal membrane receptor assay.				J Med Chem 38: 2799-801 (1995) BindingDB Entry DOI: 10.7270/Q2028S70
Zentrale Pharmaforschung Curated by ChEMBL					More data for this Ligand-Target Pair
Bradykinin B2 receptor (Cavia porcellus)	BDBM50403371 (Firazyr \| HOE-140 \| ICATIBANT) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
Zentrale Pharmaforschung Curated by ChEMBL					Assay Description In vitro antagonistic activity for Bradykinin receptor B2 by guinea pig pulmonary artery assay.				J Med Chem 38: 2799-801 (1995) BindingDB Entry DOI: 10.7270/Q2028S70
Zentrale Pharmaforschung Curated by ChEMBL					More data for this Ligand-Target Pair