Found 4 hits for monomerid = 50371229 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human)) | BDBM50371229
(Livalo | PITAVASTATIN CALCIUM | cid_24848419)Show SMILES O[C@H](C[C@H](O)\C=C\c1c(nc2ccccc2c1-c1ccc(F)cc1)C1CC1)CC([O-])=O Show InChI InChI=1S/C25H24FNO4/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31/h1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31)/p-1/b12-11+/t18-,19-/m1/s1 | PDB
UniProtKB/SwissProt
UniProtKB/TrEMBL
antibodypedia
GoogleScholar
AffyNet 
| Purchase
KEGG
PC cid
PC sid
UniChem
Similars
| PCBioAssay
| n/a | n/a | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a |
Southern Research Institute
Curated by PubChem BioAssay
| |
PubChem Bioassay (2016)
BindingDB Entry DOI: 10.7270/Q2CZ35ZF |
More data for this
Ligand-Target Pair | |
Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha
(Homo sapiens (Human)) | BDBM50371229
(Livalo | PITAVASTATIN CALCIUM | cid_24848419)Show SMILES O[C@H](C[C@H](O)\C=C\c1c(nc2ccccc2c1-c1ccc(F)cc1)C1CC1)CC([O-])=O Show InChI InChI=1S/C25H24FNO4/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31/h1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31)/p-1/b12-11+/t18-,19-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | 1.33E+4 | n/a | n/a | n/a | n/a | n/a |
Xiamen University
Curated by ChEMBL
| Assay Description
Binding affinity to RXRalpha-LBD (unknown origin) measured up to 120 sec by surface plasma resonance method |
Bioorg Med Chem Lett 27: 1055-1061 (2017)
BindingDB Entry DOI: 10.7270/Q2348NMW |
More data for this
Ligand-Target Pair | |
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA)
(Homo sapiens (Human)) | BDBM50371229
(Livalo | PITAVASTATIN CALCIUM | cid_24848419)Show SMILES O[C@H](C[C@H](O)\C=C\c1c(nc2ccccc2c1-c1ccc(F)cc1)C1CC1)CC([O-])=O Show InChI InChI=1S/C25H24FNO4/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31/h1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31)/p-1/b12-11+/t18-,19-/m1/s1 | PDB
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Pharmaceutical Industry
Curated by ChEMBL
| Assay Description
Inhibition of HMG CoA reductase by spectrophotometry |
Bioorg Med Chem 17: 7915-23 (2009)
Article DOI: 10.1016/j.bmc.2009.10.021
BindingDB Entry DOI: 10.7270/Q2D50NX1 |
More data for this
Ligand-Target Pair | |
HMG-CoA reductase
(Rattus norvegicus (rat)) | BDBM50371229
(Livalo | PITAVASTATIN CALCIUM | cid_24848419)Show SMILES O[C@H](C[C@H](O)\C=C\c1c(nc2ccccc2c1-c1ccc(F)cc1)C1CC1)CC([O-])=O Show InChI InChI=1S/C25H24FNO4/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31/h1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31)/p-1/b12-11+/t18-,19-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.06E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Pharmaceutical Industry
Curated by ChEMBL
| Assay Description
Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 mins |
Bioorg Med Chem 15: 7809-29 (2007)
Article DOI: 10.1016/j.bmc.2007.08.044
BindingDB Entry DOI: 10.7270/Q22R3SH6 |
More data for this
Ligand-Target Pair | |
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