Found 58 hits for monomerid = 50022775 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Acetylcholinesterase
(Electrophorus electricus (Electric eel)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | UniProtKB/SwissProt
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| Article
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Tested for in vitro inhibition of acetylcholinesterase |
Bioorg Med Chem Lett 5: 1131-1132 (1995)
Article DOI: 10.1016/0960-894X(95)00179-W BindingDB Entry DOI: 10.7270/Q2W37WTW |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
COMSATS Institute of Information Technology
| Assay Description Inhibition assay using AChE and BuChE. |
Chem Biol Drug Des 80: 605-15 (2012)
Article DOI: 10.1111/j.1747-0285.2012.01435.x BindingDB Entry DOI: 10.7270/Q28P5Z3T |
More data for this Ligand-Target Pair | |
Cholinesterase
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| 4.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
COMSATS Institute of Information Technology
| Assay Description Inhibition assay using AChE and BuChE. |
Chem Biol Drug Des 80: 605-15 (2012)
Article DOI: 10.1111/j.1747-0285.2012.01435.x BindingDB Entry DOI: 10.7270/Q28P5Z3T |
More data for this Ligand-Target Pair | |
Carboxylic ester hydrolase
(Equus caballus (Horse)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 4.32E+4 | n/a | n/a | n/a | n/a | 8.0 | n/a |
University of Karachi
| Assay Description Inhibitory activities of AChE and BChE were evaluated by using the Ellman's method [34]. Herein compounds 2(a-h) and 5(a-h) were evaluated as inh... |
Bioorg Chem 65: 38-47 (2016)
Article DOI: 10.1016/j.bioorg.2016.01.004 BindingDB Entry DOI: 10.7270/Q27D2SX9 |
More data for this Ligand-Target Pair | |
Carboxylic ester hydrolase
(Equus caballus (Horse)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 4.96E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Quaid-I-Azam University
| Assay Description Newly synthesized coumarin thioureas were tested against electric eel AChE and horse serum BChE. The cholinesterase inhibitory activity was measured ... |
Bioorg Chem 63: 58-63 (2015)
Article DOI: 10.1016/j.bioorg.2015.09.009 BindingDB Entry DOI: 10.7270/Q2W957Z4 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Electrophorus electricus (Electric eel)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 2.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Quaid-I-Azam University
| Assay Description Newly synthesized coumarin thioureas were tested against electric eel AChE and horse serum BChE. The cholinesterase inhibitory activity was measured ... |
Bioorg Chem 63: 58-63 (2015)
Article DOI: 10.1016/j.bioorg.2015.09.009 BindingDB Entry DOI: 10.7270/Q2W957Z4 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | 7.4 | n/a |
University of Defence
| Assay Description Human erythrocyte AChE or human plasmatic BChE (Prague, Aldrich; commercially purified by affinity chromatography) were suspended into phosphate buff... |
J Enzyme Inhib Med Chem 26: 245-53 (2011)
Article DOI: 10.3109/14756366.2010.496362 BindingDB Entry DOI: 10.7270/Q21N800H |
More data for this Ligand-Target Pair | |
Cholinesterase
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | 7.4 | n/a |
University of Defence
| Assay Description Human erythrocyte AChE or human plasmatic BChE (Prague, Aldrich; commercially purified by affinity chromatography) were suspended into phosphate buff... |
J Enzyme Inhib Med Chem 26: 245-53 (2011)
Article DOI: 10.3109/14756366.2010.496362 BindingDB Entry DOI: 10.7270/Q21N800H |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Electrophorus electricus (Electric eel)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | 8.0 | 2 |
University of Life Sciences
| Assay Description Seven different concentrations of the synthesized compounds in the range 10^−3-10^−9 M were measured at 412 nm. All the assays were under... |
J Enzyme Inhib Med Chem 28: 816-23 (2013)
Article DOI: 10.3109/14756366.2012.688041 BindingDB Entry DOI: 10.7270/Q2WW7GJ8 |
More data for this Ligand-Target Pair | |
Carboxylic ester hydrolase
(Equus caballus (Horse)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | 8.0 | 2 |
University of Life Sciences
| Assay Description Seven different concentrations of the synthesized compounds in the range 10^−3-10^−9 M were measured at 412 nm. All the assays were under... |
J Enzyme Inhib Med Chem 28: 816-23 (2013)
Article DOI: 10.3109/14756366.2012.688041 BindingDB Entry DOI: 10.7270/Q2WW7GJ8 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Electrophorus electricus (Electric eel)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | UniProtKB/SwissProt
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| PubMed
| n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
NIDDK
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against acetylcholinesterase from electric eel |
J Med Chem 31: 2297-300 (1989)
BindingDB Entry DOI: 10.7270/Q2DZ08WZ |
More data for this Ligand-Target Pair | |
Cholinesterase
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| n/a | n/a | 4.91E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Quaid-I-Azam University
Curated by ChEMBL
| Assay Description Inhibition of human BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after 15 mins by Ellman's me... |
Eur J Med Chem 78: 43-53 (2014)
Article DOI: 10.1016/j.ejmech.2014.03.015 BindingDB Entry DOI: 10.7270/Q2KW5HKK |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Electrophorus electricus (Electric eel)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Quaid-I-Azam University
Curated by ChEMBL
| Assay Description Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after ... |
Eur J Med Chem 78: 43-53 (2014)
Article DOI: 10.1016/j.ejmech.2014.03.015 BindingDB Entry DOI: 10.7270/Q2KW5HKK |
More data for this Ligand-Target Pair | |
Cholinesterase
(Equus caballus (Horse)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 4.96E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Government College Women University
Curated by ChEMBL
| Assay Description Inhibition of BuChE in equine serum using butyrylthiocholine chloride as substrate preincubated with enzyme for 10 mins prior to substrate challenge ... |
Eur J Med Chem 78: 106-17 (2014)
Article DOI: 10.1016/j.ejmech.2014.03.035 BindingDB Entry DOI: 10.7270/Q2TD9ZVD |
More data for this Ligand-Target Pair | |
Cholinesterase
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| n/a | n/a | 2.61E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Quaid-i-Azam University
Curated by ChEMBL
| Assay Description Inhibition of human BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after 15 mins by Ellman's me... |
Eur J Med Chem 78: 167-77 (2014)
Article DOI: 10.1016/j.ejmech.2014.03.046 BindingDB Entry DOI: 10.7270/Q2F76F32 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Electrophorus electricus (Electric eel)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | 1.42E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Quaid-i-Azam University
Curated by ChEMBL
| Assay Description Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after ... |
Eur J Med Chem 78: 167-77 (2014)
Article DOI: 10.1016/j.ejmech.2014.03.046 BindingDB Entry DOI: 10.7270/Q2F76F32 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd.
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against human recombinant AChE |
Bioorg Med Chem Lett 12: 193-6 (2001)
BindingDB Entry DOI: 10.7270/Q2CR5SP0 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Electrophorus electricus (Electric eel)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | 2.83E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Quaid-i-Azam University
Curated by ChEMBL
| Assay Description Inhibition of electric eel AChE by Ellman's method |
Bioorg Med Chem 22: 6163-73 (2014)
Article DOI: 10.1016/j.bmc.2014.08.026 BindingDB Entry DOI: 10.7270/Q2JQ12M3 |
More data for this Ligand-Target Pair | |
Cholinesterase
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| n/a | n/a | 1.63E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Quaid-i-Azam University
Curated by ChEMBL
| Assay Description Inhibition of human BChE by Ellman's method |
Bioorg Med Chem 22: 6163-73 (2014)
Article DOI: 10.1016/j.bmc.2014.08.026 BindingDB Entry DOI: 10.7270/Q2JQ12M3 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
N.D. Zelinsky Institute of Organic Chemistry
Curated by ChEMBL
| Assay Description Inhibition of AChE (unknown origin) using ACh chloride as substrate preincubated for 15 mins before substrate addition by Ellman method |
Bioorg Med Chem Lett 24: 3618-21 (2014)
Article DOI: 10.1016/j.bmcl.2014.05.040 BindingDB Entry DOI: 10.7270/Q26M38GD |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Electrophorus electricus (Electric eel)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | 4.11E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mysore
Curated by ChEMBL
| Assay Description Inhibition of electric eel AchE |
Bioorg Med Chem Lett 16: 3932-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.030 BindingDB Entry DOI: 10.7270/Q2RJ4J3F |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| n/a | n/a | 42.1 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mysore
Curated by ChEMBL
| Assay Description Inhibition of human serum AchE |
Bioorg Med Chem Lett 16: 3932-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.030 BindingDB Entry DOI: 10.7270/Q2RJ4J3F |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Rattus norvegicus (rat)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | 37.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mysore
Curated by ChEMBL
| Assay Description Inhibition of rat brain homogenate AchE |
Bioorg Med Chem Lett 16: 3932-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.030 BindingDB Entry DOI: 10.7270/Q2RJ4J3F |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Rattus norvegicus (rat)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mysore
Curated by ChEMBL
| Assay Description Inhibition of Wistar rat brain homogenate AChE by Ellman's assay |
Eur J Med Chem 44: 4057-62 (2009)
Article DOI: 10.1016/j.ejmech.2009.04.042 BindingDB Entry DOI: 10.7270/Q2MK6CZF |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| DrugBank Article PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mysore
Curated by ChEMBL
| Assay Description Inhibition of human serum AChE by Ellman's assay |
Eur J Med Chem 44: 4057-62 (2009)
Article DOI: 10.1016/j.ejmech.2009.04.042 BindingDB Entry DOI: 10.7270/Q2MK6CZF |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Electrophorus electricus (Electric eel)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mysore
Curated by ChEMBL
| Assay Description Inhibition of electric eel AChE by Ellman's method |
Eur J Med Chem 44: 4057-62 (2009)
Article DOI: 10.1016/j.ejmech.2009.04.042 BindingDB Entry DOI: 10.7270/Q2MK6CZF |
More data for this Ligand-Target Pair | |
Cholinesterase
(Equus caballus (Horse)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB
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Similars
| Article PubMed
| n/a | n/a | 9.27E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of horse serum BChE incubated for 5 mins by DTNB reagent based Ellman's method |
Citation and Details
Article DOI: 10.1021/acs.jnatprod.1c00980 BindingDB Entry DOI: 10.7270/Q2125XJV |
More data for this Ligand-Target Pair | |
Cholinesterase
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| DrugBank Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Military Health Sciences
Curated by ChEMBL
| Assay Description Inhibition of human plasma BChE after 5 mins by Ellman's method |
Bioorg Med Chem Lett 20: 1763-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.034 BindingDB Entry DOI: 10.7270/Q2BK1CGS |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd.
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against acetylcholinesterase |
Bioorg Med Chem Lett 12: 753-5 (2002)
BindingDB Entry DOI: 10.7270/Q21J9B91 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of guinea pig acetylcholinesterase |
J Med Chem 36: 572-9 (1993)
BindingDB Entry DOI: 10.7270/Q2930TSP |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina
Curated by ChEMBL
| Assay Description Inhibitory activity against Acetylcholinesterase |
J Med Chem 39: 5064-71 (1997)
Article DOI: 10.1021/jm950771r BindingDB Entry DOI: 10.7270/Q2PZ59GC |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mysore
Curated by ChEMBL
| Assay Description Inhibition of human serum AChE by Ellman colorimetric assay |
Bioorg Med Chem 15: 7391-8 (2007)
Article DOI: 10.1016/j.bmc.2007.07.014 BindingDB Entry DOI: 10.7270/Q2FB53R3 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Electrophorus electricus (Electric eel)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | 47.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mysore
Curated by ChEMBL
| Assay Description Inhibition of electric eel AChE by Ellman colorimetric assay |
Bioorg Med Chem 15: 7391-8 (2007)
Article DOI: 10.1016/j.bmc.2007.07.014 BindingDB Entry DOI: 10.7270/Q2FB53R3 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Rattus norvegicus (rat)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mysore
Curated by ChEMBL
| Assay Description Inhibition of Wistar rat brain AChE by Ellman colorimetric assay |
Bioorg Med Chem 15: 7391-8 (2007)
Article DOI: 10.1016/j.bmc.2007.07.014 BindingDB Entry DOI: 10.7270/Q2FB53R3 |
More data for this Ligand-Target Pair | |
Cholinesterase
(Equus caballus (Horse)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB
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Similars
| Article PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of equine serum BChE using butylthiocholine iodide as substrate after 10 mins by Ellman method |
Eur J Med Chem 62: 311-9 (2013)
Article DOI: 10.1016/j.ejmech.2012.12.060 BindingDB Entry DOI: 10.7270/Q27S7Q4V |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Electrophorus electricus (Electric eel)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of electric eel AChE using acetylcholine iodide as substrate after 10 mins by Ellman method |
Eur J Med Chem 62: 311-9 (2013)
Article DOI: 10.1016/j.ejmech.2012.12.060 BindingDB Entry DOI: 10.7270/Q27S7Q4V |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| n/a | n/a | 91.0 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard University
Curated by ChEMBL
| Assay Description Inhibition acetylcholinesterase (AChE) enzyme. |
J Med Chem 40: 4360-71 (1998)
Article DOI: 10.1021/jm970488n BindingDB Entry DOI: 10.7270/Q2BZ6784 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
NCI pathway Reactome pathway KEGG
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Similars
| DrugBank Article PubMed
| n/a | n/a | 0.0430 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human acetylcholine esterase |
Bioorg Med Chem 18: 7675-99 (2010)
Article DOI: 10.1016/j.bmc.2010.07.034 BindingDB Entry DOI: 10.7270/Q2DF6S69 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
NCI pathway Reactome pathway KEGG
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Similars
| DrugBank Article PubMed
| n/a | n/a | 18.8 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Aging
Curated by ChEMBL
| Assay Description Inhibition of human whole RBC AChE pretreated for 30 mins by Ellman technique |
Bioorg Med Chem 18: 4687-93 (2011)
Article DOI: 10.1016/j.bmc.2010.05.022 BindingDB Entry DOI: 10.7270/Q2KS6SHB |
More data for this Ligand-Target Pair | |
Cholinesterase
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| DrugBank Article PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Aging
Curated by ChEMBL
| Assay Description Inhibition of human plasma BChE pretreated for 30 mins by Ellman technique |
Bioorg Med Chem 18: 4687-93 (2011)
Article DOI: 10.1016/j.bmc.2010.05.022 BindingDB Entry DOI: 10.7270/Q2KS6SHB |
More data for this Ligand-Target Pair | |
Bile salt export pump
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB
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| Article PubMed
| n/a | n/a | >1.35E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t... |
Toxicol Sci 118: 485-500 (2010)
Article DOI: 10.1093/toxsci/kfq269 BindingDB Entry DOI: 10.7270/Q26Q20JN |
More data for this Ligand-Target Pair | |
Bile salt export pump
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB
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Similars
| Article PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-... |
Drug Metab Dispos 40: 2332-41 (2012)
Article DOI: 10.1124/dmd.112.047068 BindingDB Entry DOI: 10.7270/Q2ZP488M |
More data for this Ligand-Target Pair | |
Bile salt export pump
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB
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Similars
| Article PubMed
| n/a | n/a | >1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ... |
Toxicol Sci 136: 216-41 (2013)
Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family C member 3
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | >1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ... |
Toxicol Sci 136: 216-41 (2013)
Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family C member 4
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | >1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and... |
Toxicol Sci 136: 216-41 (2013)
Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family C member 2
(Homo sapiens (Human)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB
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Similars
| Article PubMed
| n/a | n/a | >1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and... |
Toxicol Sci 136: 216-41 (2013)
Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Electrophorus electricus (Electric eel)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 1.63E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wuhan Institute of Technology
Curated by ChEMBL
| Assay Description Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured after 15... |
Eur J Med Chem 180: 656-672 (2019)
Article DOI: 10.1016/j.ejmech.2019.07.059 BindingDB Entry DOI: 10.7270/Q22B92D9 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Electrophorus electricus (Electric eel)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | 7.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of electric eel AChE by Ellman's method |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127505 BindingDB Entry DOI: 10.7270/Q24171NS |
More data for this Ligand-Target Pair | |
Cholinesterase
(Equus caballus (Horse)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB
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Similars
| Article PubMed
| n/a | n/a | 2.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of equine BuChE by Ellman's method |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127505 BindingDB Entry DOI: 10.7270/Q24171NS |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Rattus norvegicus (rat)) | BDBM50022775
((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)Show InChI InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 | PDB MMDB
KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of AChE in rat brain cortex |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128206 BindingDB Entry DOI: 10.7270/Q2G73JHV |
More data for this Ligand-Target Pair | |