BDBM50339134 3-(2-Chloro-phenothiazin-10-yl)-propylamine::3-(2-chloro-10H-phenothiazin-10-yl)propan-1-amine::CHEMBL824::Nor2-Chlorpromazine
SMILES: NCCCN1c2ccccc2Sc2ccc(Cl)cc12
InChI Key: InChIKey=ZTQZBABFEUDZFE-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pleiotropic ABC efflux transporter of multiple drugs (Saccharomyces cerevisiae S288c) | BDBM50339134 (3-(2-Chloro-phenothiazin-10-yl)-propylamine | 3-(2...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wroclaw Medical University Curated by ChEMBL | Assay Description Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR5h plasma membrane by spectrofluorometric assay | Antimicrob Agents Chemother 53: 1516-27 (2009) Article DOI: 10.1128/AAC.00956-08 BindingDB Entry DOI: 10.7270/Q2125TNZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trypanothione reductase (Trypanosoma cruzi) | BDBM50339134 (3-(2-Chloro-phenothiazin-10-yl)-propylamine | 3-(2...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.39E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manchester Curated by ChEMBL | Assay Description Inhibitory activity against recombinant Trypanosoma cruzi (Trypanosoma cruzi) Trypanothione reductase | J Med Chem 41: 148-56 (1998) Article DOI: 10.1021/jm960814j BindingDB Entry DOI: 10.7270/Q2ZP457X | |||||||||||
More data for this Ligand-Target Pair |