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BDBM50002861 3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid::CHEMBL1071::Daypro::OXAPROZIN::WY-21743::oxaprosin
SMILES: OC(=O)CCc1nc(c(o1)-c1ccccc1)-c1ccccc1
InChI Key: InChIKey=OFPXSFXSNFPTHF-UHFFFAOYSA-N
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cyclooxygenase-1 (COX-1) (Homo sapiens (Human)) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dallas Department of Veterans Affairs Medical Center Curated by PDSP Ki Database | Am J Med 104: 413-21 (1998) Article DOI: 10.1016/s0002-9343(98)00091-6 BindingDB Entry DOI: 10.7270/Q2F18X97 | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclooxygenase (Homo sapiens (Human)) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | DrugBank Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dallas Department of Veterans Affairs Medical Center Curated by PDSP Ki Database | Am J Med 104: 413-21 (1998) Article DOI: 10.1016/s0002-9343(98)00091-6 BindingDB Entry DOI: 10.7270/Q2F18X97 | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-lactamase AmpC (Escherichia coli) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >4.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Curated by ChEMBL | Assay Description Compound was tested for the inhibition of beta-lactamase | J Med Chem 46: 4477-86 (2003) Article DOI: 10.1021/jm030191r BindingDB Entry DOI: 10.7270/Q2X34Z5C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bile salt export pump (Homo sapiens (Human)) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc Curated by ChEMBL | Assay Description Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ... | Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Canalicular multispecific organic anion transporter 1 (Homo sapiens (Human)) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc Curated by ChEMBL | Assay Description Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and... | Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Multidrug resistance-associated protein 4 (Homo sapiens (Human)) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc Curated by ChEMBL | Assay Description Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and... | Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Canalicular multispecific organic anion transporter 2 (Homo sapiens (Human)) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc Curated by ChEMBL | Assay Description Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ... | Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Complement C5 (Homo sapiens) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 640 | n/a | n/a | n/a | n/a | n/a |
Indian Institute of Technology Bhubaneswar Curated by ChEMBL | Assay Description Binding affinity to human C5a assessed as dissociation constant after 1 hr by circular dichroism analysis | Bioorg Med Chem 27: (2019) Article DOI: 10.1016/j.bmc.2019.115052 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Prostaglandin E synthase/G/H synthase 2 (Homo sapiens (Human)) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Inhibition of COX2 in LPS-stimulated human monocytes assessed as reduction in PGE2 production by LC-tandem MIS analysis | J Med Chem 62: 8443-8460 (2019) Article DOI: 10.1021/acs.jmedchem.9b00445 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| EBifunctional epoxide hydrolase 2 (Homo sapiens (Human)) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Inhibition of phosphatase activity of full length human soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluoresc... | J Med Chem 62: 8443-8460 (2019) Article DOI: 10.1021/acs.jmedchem.9b00445 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Epoxide hydrolase 2 (Rattus norvegicus) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Inhibition of hydrolase activity of full length rat soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluorescen... | J Med Chem 62: 8443-8460 (2019) Article DOI: 10.1021/acs.jmedchem.9b00445 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Prostaglandin E synthase/G/H synthase 2 (Homo sapiens (Human)) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Inhibition of COX2 in LPS-stimulated human monocytes assessed as reduction in PGE2 production by LC-tandem MIS analysis | J Med Chem 62: 8443-8460 (2019) Article DOI: 10.1021/acs.jmedchem.9b00445 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Epoxide hydratase (Mus musculus (Mouse)) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.55E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Inhibition of phosphatase activity of full length mouse soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluoresc... | J Med Chem 62: 8443-8460 (2019) Article DOI: 10.1021/acs.jmedchem.9b00445 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Epoxide hydrolase 2 (Rattus norvegicus) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Inhibition of hydrolase activity of full length rat soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluorescen... | J Med Chem 62: 8443-8460 (2019) Article DOI: 10.1021/acs.jmedchem.9b00445 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| EBifunctional epoxide hydrolase 2 (Homo sapiens (Human)) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Inhibition of hydrolase activity of full length human soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluoresc... | J Med Chem 62: 8443-8460 (2019) Article DOI: 10.1021/acs.jmedchem.9b00445 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclooxygenase (Homo sapiens (Human)) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 740 | n/a | n/a | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Inhibition of COX1 in A23187-stimulated human platelets assessed as reduction in TXA2 production | J Med Chem 62: 8443-8460 (2019) Article DOI: 10.1021/acs.jmedchem.9b00445 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Epoxide hydratase (Mus musculus (Mouse)) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.55E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Inhibition of phosphatase activity of full length mouse soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluoresc... | J Med Chem 62: 8443-8460 (2019) Article DOI: 10.1021/acs.jmedchem.9b00445 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Epoxide hydrolase 2 (Rattus norvegicus) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Inhibition of phosphatase activity of full length rat soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluorescen... | J Med Chem 62: 8443-8460 (2019) Article DOI: 10.1021/acs.jmedchem.9b00445 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| EBifunctional epoxide hydrolase 2 (Homo sapiens (Human)) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Inhibition of phosphatase activity of full length human soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluoresc... | J Med Chem 62: 8443-8460 (2019) Article DOI: 10.1021/acs.jmedchem.9b00445 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Epoxide hydrolase 2 (Rattus norvegicus) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Inhibition of phosphatase activity of full length rat soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluorescen... | J Med Chem 62: 8443-8460 (2019) Article DOI: 10.1021/acs.jmedchem.9b00445 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclooxygenase (Homo sapiens (Human)) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 740 | n/a | n/a | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Inhibition of COX1 in A23187-stimulated human platelets assessed as reduction in TXA2 production | J Med Chem 62: 8443-8460 (2019) Article DOI: 10.1021/acs.jmedchem.9b00445 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Epoxide hydratase (Mus musculus (Mouse)) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Inhibition of hydrolase activity of full length mouse soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluoresc... | J Med Chem 62: 8443-8460 (2019) Article DOI: 10.1021/acs.jmedchem.9b00445 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Epoxide hydratase (Mus musculus (Mouse)) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Inhibition of hydrolase activity of full length mouse soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluoresc... | J Med Chem 62: 8443-8460 (2019) Article DOI: 10.1021/acs.jmedchem.9b00445 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Malate dehydrogenase cytoplasmic (Homo sapiens (Human)) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.75E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Curated by ChEMBL | Assay Description Inhibition of malate dehydrogenase (MDH) | J Med Chem 46: 4477-86 (2003) Article DOI: 10.1021/jm030191r BindingDB Entry DOI: 10.7270/Q2X34Z5C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-chymotrypsin (Bos taurus (bovine)) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Curated by ChEMBL | Assay Description Compound was tested for the inhibition of Chymotrypsinogen | J Med Chem 46: 4477-86 (2003) Article DOI: 10.1021/jm030191r BindingDB Entry DOI: 10.7270/Q2X34Z5C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| EBifunctional epoxide hydrolase 2 (Homo sapiens (Human)) | BDBM50002861 (3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Inhibition of hydrolase activity of full length human soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluoresc... | J Med Chem 62: 8443-8460 (2019) Article DOI: 10.1021/acs.jmedchem.9b00445 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
