Found 21 hits for monomerid = 50105417 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM50105417
(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)Show InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2 | PDB
UniProtKB/SwissProt
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| Article PubMed
| 94 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dart NeuroScience, LLC
Curated by ChEMBL
| Assay Description Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b... |
Bioorg Med Chem 23: 770-8 (2015)
Article DOI: 10.1016/j.bmc.2014.12.063 BindingDB Entry DOI: 10.7270/Q2J38V8K |
More data for this Ligand-Target Pair | |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM50105417
(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)Show InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2 | PDB
UniProtKB/SwissProt
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Similars
| Article PubMed
| 124 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University
Curated by ChEMBL
| Assay Description Mixed-type inhibition of recombinant human MAO-B assessed as reduction in 4-hydroxyquinoline formation using varying levels of kynuramine as substrat... |
J Nat Prod 79: 2538-2544 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00440 BindingDB Entry DOI: 10.7270/Q26W9DHJ |
More data for this Ligand-Target Pair | |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM50105417
(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)Show InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2 | PDB
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| Article PubMed
| 163 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University
Curated by ChEMBL
| Assay Description Mixed-type inhibition of recombinant human MAO-A assessed as reduction in 4-hydroxyquinoline formation using varying levels of kynuramine as substrat... |
J Nat Prod 79: 2538-2544 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00440 BindingDB Entry DOI: 10.7270/Q26W9DHJ |
More data for this Ligand-Target Pair | |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM50105417
(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)Show InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2 | PDB
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| Article PubMed
| 820 | n/a | n/a | n/a | n/a | n/a | n/a | 7.5 | n/a |
Johns Hopkins University School of Medicine , Baltimore, Maryland 21205, United States
| Assay Description Reactions (100 µL) were initiated by the addition of 2 µL MAO-A/B (final concentrations were 100-200 nM and 0.837 µM for MAO-A and MAO... |
ACS Chem Biol 9: 1284-93 (2014)
Article DOI: 10.1021/cb500018s BindingDB Entry DOI: 10.7270/Q2FN14VF |
More data for this Ligand-Target Pair | |
Cytochrome P450 2C8
(Homo sapiens (Human)) | BDBM50105417
(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)Show InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2 | PDB
KEGG
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| DrugBank PubMed
| 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Mechanism based inhibition of human cytochrome P450 2C8 measured by paclitaxel hydroxylation using a recombinant system |
Curr Drug Metab 6: 413-54 (2005)
BindingDB Entry DOI: 10.7270/Q2VQ33X3 |
More data for this Ligand-Target Pair | |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM50105417
(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)Show InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2 | PDB
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| Article PubMed
| 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 7.5 | n/a |
Johns Hopkins University School of Medicine , Baltimore, Maryland 21205, United States
| Assay Description Reactions (100 µL) were initiated by the addition of 2 µL MAO-A/B (final concentrations were 100-200 nM and 0.837 µM for MAO-A and MAO... |
ACS Chem Biol 9: 1284-93 (2014)
Article DOI: 10.1021/cb500018s BindingDB Entry DOI: 10.7270/Q2FN14VF |
More data for this Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM50105417
(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)Show InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2 | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 7.5 | n/a |
Johns Hopkins University School of Medicine , Baltimore, Maryland 21205, United States
| Assay Description Reactions (100 µL) were initiated by the addition of 2 µL of GST-LSD1 (final concentration 96-154 nM). The reaction mixture contained 50 mM... |
ACS Chem Biol 9: 1284-93 (2014)
Article DOI: 10.1021/cb500018s BindingDB Entry DOI: 10.7270/Q2FN14VF |
More data for this Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM50105417
(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)Show InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2 | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Zhengzhou University
Curated by ChEMBL
| Assay Description Dissociation constant against galectin-3 using competitive fluorescence polarization |
Eur J Med Chem 125: 940-951 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.021 BindingDB Entry DOI: 10.7270/Q2ZC8597 |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50105417
(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)Show InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2 | NCI pathway Reactome pathway KEGG
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| Article PubMed
| 8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Clinic Jacksonville
Curated by PDSP Ki Database
| |
Eur J Pharmacol 340: 249-58 (1997)
Article DOI: 10.1016/s0014-2999(97)01393-9 BindingDB Entry DOI: 10.7270/Q2V69H3D |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50105417
(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)Show InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2 | PDB
KEGG
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Clinic Jacksonville
Curated by PDSP Ki Database
| |
Eur J Pharmacol 340: 249-58 (1997)
Article DOI: 10.1016/s0014-2999(97)01393-9 BindingDB Entry DOI: 10.7270/Q2V69H3D |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50105417
(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)Show InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2 | Reactome pathway KEGG
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Clinic Jacksonville
Curated by PDSP Ki Database
| |
Eur J Pharmacol 340: 249-58 (1997)
Article DOI: 10.1016/s0014-2999(97)01393-9 BindingDB Entry DOI: 10.7270/Q2V69H3D |
More data for this Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM50105417
(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)Show InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2 | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 1.76E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Inhibition of LSD1 |
Bioorg Med Chem 19: 3625-36 (2011)
Article DOI: 10.1016/j.bmc.2011.01.046 BindingDB Entry DOI: 10.7270/Q23X870S |
More data for this Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM50105417
(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)Show InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2 | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto Prefectural University of Medicine
Curated by ChEMBL
| Assay Description Inhibition of LSD1 |
J Med Chem 54: 8236-50 (2011)
Article DOI: 10.1021/jm201048w BindingDB Entry DOI: 10.7270/Q2D50NFR |
More data for this Ligand-Target Pair | |
Cytochrome P450 2C8
(Homo sapiens (Human)) | BDBM50105417
(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)Show InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2 | PDB
KEGG
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| DrugBank PubMed
| 5.43E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Mechanism based inhibition of human cytochrome P450 2C8 measured by paclitaxel hydroxylation using human liver microsomes |
Curr Drug Metab 6: 413-54 (2005)
BindingDB Entry DOI: 10.7270/Q2VQ33X3 |
More data for this Ligand-Target Pair | |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM50105417
(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)Show InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2 | PDB
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| Article PubMed
| n/a | n/a | 238 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A assessed as reduction in 4-hydroxyquinoline formation using kynuramine as substrate after 20 mins by fluorometr... |
J Nat Prod 79: 2538-2544 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00440 BindingDB Entry DOI: 10.7270/Q26W9DHJ |
More data for this Ligand-Target Pair | |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM50105417
(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)Show InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2 | PDB
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | 143 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-B assessed as reduction in 4-hydroxyquinoline formation using kynuramine as substrate after 20 mins by fluorometr... |
J Nat Prod 79: 2538-2544 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00440 BindingDB Entry DOI: 10.7270/Q26W9DHJ |
More data for this Ligand-Target Pair | |
Bile salt export pump
(Homo sapiens (Human)) | BDBM50105417
(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)Show InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2 | PDB
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | >8.97E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-... |
Drug Metab Dispos 40: 2332-41 (2012)
Article DOI: 10.1124/dmd.112.047068 BindingDB Entry DOI: 10.7270/Q2ZP488M |
More data for this Ligand-Target Pair | |
Vascular adhesion protein 1 (VAP-1)
(Homo sapiens (Human)) | BDBM50105417
(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)Show InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2 | PDB MMDB
KEGG
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| DrugBank Article PubMed
| n/a | n/a | 19.9 | n/a | n/a | n/a | n/a | n/a | n/a |
FI-40014 University of Jyvaskyla
Curated by ChEMBL
| Assay Description Inhibition of human recombinant VAP-1 expressed in CHO cells after 30 mins by coupled colorimetric method |
J Med Chem 53: 6301-15 (2010)
Article DOI: 10.1021/jm100337z BindingDB Entry DOI: 10.7270/Q2V1261D |
More data for this Ligand-Target Pair | |
Monoamine Oxidase Type B (MAO-B)
(Rattus norvegicus (rat)) | BDBM50105417
(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)Show InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2 | PDB MMDB
KEGG
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Patents
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| PubMed
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
CV Technologies Inc.
Curated by ChEMBL
| Assay Description In vitro ability of the compound to inhibit Monoamine oxidase B activity in rat whole brain in vitro |
Bioorg Med Chem Lett 11: 2715-7 (2001)
BindingDB Entry DOI: 10.7270/Q2Z60NC5 |
More data for this Ligand-Target Pair | |
Monoamine oxidase
(Rattus norvegicus (rat)) | BDBM50105417
(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)Show InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2 | PDB MMDB
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Patents
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| PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
CV Technologies Inc.
Curated by ChEMBL
| Assay Description In vitro ability of the compound to inhibit Monoamine oxidase A activity in rat whole brain in vitro |
Bioorg Med Chem Lett 11: 2715-7 (2001)
BindingDB Entry DOI: 10.7270/Q2Z60NC5 |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase
(Homo sapiens (Human)) | BDBM50105417
(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)Show InChI InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2 | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Swiss Institute of Bioinformatics
Curated by ChEMBL
| Assay Description Inhibition of IDO1 (unknown origin) using L-tryptophan substrate incubated for 60 mins by HPLC |
Eur J Med Chem 84: 284-301 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.078 BindingDB Entry DOI: 10.7270/Q21C1ZJV |
More data for this Ligand-Target Pair | |