BindingDB PrimarySearch

BDBM50053588 (S)-4-(amino(carboxy)methyl)benzoic acid::(S)-4-carboxyphenylglycine::4-((S)-Amino-carboxy-methyl)-benzoic acid::4-(Amino-carboxy-methyl)-benzoic acid::CHEMBL94990::S-4-Carboxyphenylglycine

SMILES: N[C@H](C(O)=O)c1ccc(cc1)C(O)=O

InChI Key: InChIKey=VTMJKPGFERYGJF-ZETCQYMHSA-N

Data: 11 KI 6 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50053588
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Metabotropic glutamate receptor (RAT)	BDBM50053588 ((S)-4-(amino(carboxy)methyl)benzoic acid \| (S)-4-c...) Show SMILES N[C@H](C(O)=O)c1ccc(cc1)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Parc Club Orsay Universit£ Curated by ChEMBL					Assay Description Binding affinity at Metabotropic glutamate receptor 1				J Med Chem 45: 3171-83 (2002) BindingDB Entry DOI: 10.7270/Q2B27W18
Parc Club Orsay Universit£ Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50053588 ((S)-4-(amino(carboxy)methyl)benzoic acid \| (S)-4-c...) Show SMILES N[C@H](C(O)=O)c1ccc(cc1)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by PDSP K_i Database									Eur J Pharmacol 267: 77-84 (1994) Article DOI: 10.1016/0922-4106(94)90227-5 BindingDB Entry DOI: 10.7270/Q2RX99MZ
Novo Nordisk A/S Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (RAT)	BDBM50053588 ((S)-4-(amino(carboxy)methyl)benzoic acid \| (S)-4-c...) Show SMILES N[C@H](C(O)=O)c1ccc(cc1)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by PDSP K_i Database									Eur J Pharmacol 267: 77-84 (1994) Article DOI: 10.1016/0922-4106(94)90227-5 BindingDB Entry DOI: 10.7270/Q2RX99MZ
Novo Nordisk A/S Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (RAT)	BDBM50053588 ((S)-4-(amino(carboxy)methyl)benzoic acid \| (S)-4-c...) Show SMILES N[C@H](C(O)=O)c1ccc(cc1)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by PDSP K_i Database									Eur J Pharmacol 267: 77-84 (1994) Article DOI: 10.1016/0922-4106(94)90227-5 BindingDB Entry DOI: 10.7270/Q2RX99MZ
Novo Nordisk A/S Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50053588 ((S)-4-(amino(carboxy)methyl)benzoic acid \| (S)-4-c...) Show SMILES N[C@H](C(O)=O)c1ccc(cc1)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by PDSP K_i Database									Eur J Pharmacol 267: 77-84 (1994) Article DOI: 10.1016/0922-4106(94)90227-5 BindingDB Entry DOI: 10.7270/Q2RX99MZ
Novo Nordisk A/S Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4) (Rattus norvegicus (Rat))	BDBM50053588 ((S)-4-(amino(carboxy)methyl)benzoic acid \| (S)-4-c...) Show SMILES N[C@H](C(O)=O)c1ccc(cc1)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by PDSP K_i Database									Eur J Pharmacol 267: 77-84 (1994) Article DOI: 10.1016/0922-4106(94)90227-5 BindingDB Entry DOI: 10.7270/Q2RX99MZ
Novo Nordisk A/S Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (RAT)	BDBM50053588 ((S)-4-(amino(carboxy)methyl)benzoic acid \| (S)-4-c...) Show SMILES N[C@H](C(O)=O)c1ccc(cc1)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by PDSP K_i Database									Eur J Pharmacol 350: 311-6 (1998) Article DOI: 10.1016/s0014-2999(98)00246-5 BindingDB Entry DOI: 10.7270/Q2FT8JK6
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50053588 ((S)-4-(amino(carboxy)methyl)benzoic acid \| (S)-4-c...) Show SMILES N[C@H](C(O)=O)c1ccc(cc1)C(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by PDSP K_i Database									Eur J Pharmacol 350: 311-6 (1998) Article DOI: 10.1016/s0014-2999(98)00246-5 BindingDB Entry DOI: 10.7270/Q2FT8JK6
					More data for this Ligand-Target Pair
GRIA3 (RAT)	BDBM50053588 ((S)-4-(amino(carboxy)methyl)benzoic acid \| (S)-4-c...) Show SMILES N[C@H](C(O)=O)c1ccc(cc1)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by PDSP K_i Database									Eur J Pharmacol 267: 77-84 (1994) Article DOI: 10.1016/0922-4106(94)90227-5 BindingDB Entry DOI: 10.7270/Q2RX99MZ
Novo Nordisk A/S Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1 (RAT)	BDBM50053588 ((S)-4-(amino(carboxy)methyl)benzoic acid \| (S)-4-c...) Show SMILES N[C@H](C(O)=O)c1ccc(cc1)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by PDSP K_i Database									Eur J Pharmacol 267: 77-84 (1994) Article DOI: 10.1016/0922-4106(94)90227-5 BindingDB Entry DOI: 10.7270/Q2RX99MZ
Novo Nordisk A/S Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4) (Homo sapiens (Human))	BDBM50053588 ((S)-4-(amino(carboxy)methyl)benzoic acid \| (S)-4-c...) Show SMILES N[C@H](C(O)=O)c1ccc(cc1)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	8.38E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Parc Club Orsay Universit£ Curated by ChEMBL					Assay Description Binding affinity at Metabotropic glutamate receptor 4				J Med Chem 45: 3171-83 (2002) BindingDB Entry DOI: 10.7270/Q2B27W18
Parc Club Orsay Universit£ Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50053588 ((S)-4-(amino(carboxy)methyl)benzoic acid \| (S)-4-c...) Show SMILES N[C@H](C(O)=O)c1ccc(cc1)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Università di Perugia Curated by ChEMBL					Assay Description Inhibitory concentration of the compound for half maximal inhibition of PI hydrolysis (mGluR1a)				J Med Chem 39: 3998-4006 (1996) Article DOI: 10.1021/jm9601718 BindingDB Entry DOI: 10.7270/Q2765DFJ
Università di Perugia Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50053588 ((S)-4-(amino(carboxy)methyl)benzoic acid \| (S)-4-c...) Show SMILES N[C@H](C(O)=O)c1ccc(cc1)C(O)=O \|r\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	1.55E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for functional response of human metabotropic glutamate receptor mGluR5a expressed in AV-12 cells by measuring inhibitory concent...				Bioorg Med Chem Lett 7: 2777-2780 (1997) Article DOI: 10.1016/S0960-894X(97)10071-3 BindingDB Entry DOI: 10.7270/Q25Q4W4G
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Cystine/glutamate transporter (Homo sapiens (Human))	BDBM50053588 ((S)-4-(amino(carboxy)methyl)benzoic acid \| (S)-4-c...) Show SMILES N[C@H](C(O)=O)c1ccc(cc1)C(O)=O \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Montana Curated by ChEMBL					Assay Description Inhibition of amino acid transport system xc-				Bioorg Med Chem Lett 20: 2680-3 (2010) Article DOI: 10.1016/j.bmcl.2009.10.020 BindingDB Entry DOI: 10.7270/Q29Z952F
The University of Montana Curated by ChEMBL					More data for this Ligand-Target Pair
Cystine/glutamate transporter (Homo sapiens (Human))	BDBM50053588 ((S)-4-(amino(carboxy)methyl)benzoic acid \| (S)-4-c...) Show SMILES N[C@H](C(O)=O)c1ccc(cc1)C(O)=O \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johns Hopkins University Curated by ChEMBL					Assay Description Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...				Bioorg Med Chem Lett 21: 6184-7 (2011) Article DOI: 10.1016/j.bmcl.2011.07.081 BindingDB Entry DOI: 10.7270/Q21V5FCR
Johns Hopkins University Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50053588 ((S)-4-(amino(carboxy)methyl)benzoic acid \| (S)-4-c...) Show SMILES N[C@H](C(O)=O)c1ccc(cc1)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Labs Curated by ChEMBL					Assay Description Antagonist activity at mGlu1 receptor				J Med Chem 50: 2563-8 (2007) Article DOI: 10.1021/jm060950g BindingDB Entry DOI: 10.7270/Q2XS5W7Q
Lilly Research Labs Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50053588 ((S)-4-(amino(carboxy)methyl)benzoic acid \| (S)-4-c...) Show SMILES N[C@H](C(O)=O)c1ccc(cc1)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	5.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for functional response of human metabotropic glutamate receptor mGluR1-alpha expressed in AV-12 cells by measuring inhibitory co...				Bioorg Med Chem Lett 7: 2777-2780 (1997) Article DOI: 10.1016/S0960-894X(97)10071-3 BindingDB Entry DOI: 10.7270/Q25Q4W4G
TBA Curated by ChEMBL					More data for this Ligand-Target Pair