Found 14 hits for monomerid = 50162073 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Oligopeptide transporter, kidney isoform
(Rattus norvegicus) | BDBM50162073
((S)-2-((2-amino-6-oxo-3H-purin-9(6H)-yl)methoxy)et...)Show SMILES CC(C)[C@H](N)C(=O)OCCOCn1cnc2c1nc(N)[nH]c2=O |r| Show InChI InChI=1S/C13H20N6O4/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20)/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| Article PubMed
| 1.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical College of Georgia
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Gly-Sar uptake in SKPT cells |
Biochem Biophys Res Commun 246: 470-5 (1998)
Article DOI: 10.1006/bbrc.1998.8628 BindingDB Entry DOI: 10.7270/Q2RR223Z |
More data for this Ligand-Target Pair | |
Oligopeptide transporter, kidney isoform
(Rattus norvegicus) | BDBM50162073
((S)-2-((2-amino-6-oxo-3H-purin-9(6H)-yl)methoxy)et...)Show SMILES CC(C)[C@H](N)C(=O)OCCOCn1cnc2c1nc(N)[nH]c2=O |r| Show InChI InChI=1S/C13H20N6O4/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20)/t8-/m0/s1 | PDB
Reactome pathway KEGG
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| 2.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT2-expressing LLC-PK1 cells |
J Pharmacol Exp Ther 291: 705-9 (1999)
BindingDB Entry DOI: 10.7270/Q29P34J8 |
More data for this Ligand-Target Pair | |
Oligopeptide transporter, kidney isoform
(Rattus norvegicus) | BDBM50162073
((S)-2-((2-amino-6-oxo-3H-purin-9(6H)-yl)methoxy)et...)Show SMILES CC(C)[C@H](N)C(=O)OCCOCn1cnc2c1nc(N)[nH]c2=O |r| Show InChI InChI=1S/C13H20N6O4/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20)/t8-/m0/s1 | PDB
Reactome pathway KEGG
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| 2.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT2-expressing LLC-PK1 cells |
J Pharmacol Exp Ther 291: 705-9 (1999)
BindingDB Entry DOI: 10.7270/Q29P34J8 |
More data for this Ligand-Target Pair | |
Oligopeptide transporter, kidney isoform
(Rattus norvegicus) | BDBM50162073
((S)-2-((2-amino-6-oxo-3H-purin-9(6H)-yl)methoxy)et...)Show SMILES CC(C)[C@H](N)C(=O)OCCOCn1cnc2c1nc(N)[nH]c2=O |r| Show InChI InChI=1S/C13H20N6O4/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20)/t8-/m0/s1 | PDB
Reactome pathway KEGG
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| Article PubMed
| 3.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical College of Georgia
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT2-expressing HeLa cells |
Biochem Biophys Res Commun 246: 470-5 (1998)
Article DOI: 10.1006/bbrc.1998.8628 BindingDB Entry DOI: 10.7270/Q2RR223Z |
More data for this Ligand-Target Pair | |
Oligopeptide transporter small intestine isoform
(Homo sapiens (Human)) | BDBM50162073
((S)-2-((2-amino-6-oxo-3H-purin-9(6H)-yl)methoxy)et...)Show SMILES CC(C)[C@H](N)C(=O)OCCOCn1cnc2c1nc(N)[nH]c2=O |r| Show InChI InChI=1S/C13H20N6O4/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20)/t8-/m0/s1 | PDB
Reactome pathway KEGG
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| Article PubMed
| 4.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical College of Georgia
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Gly-Sar uptake in Caco-2 cells |
Biochem Biophys Res Commun 246: 470-5 (1998)
Article DOI: 10.1006/bbrc.1998.8628 BindingDB Entry DOI: 10.7270/Q2RR223Z |
More data for this Ligand-Target Pair | |
Oligopeptide transporter small intestine isoform
(Homo sapiens (Human)) | BDBM50162073
((S)-2-((2-amino-6-oxo-3H-purin-9(6H)-yl)methoxy)et...)Show SMILES CC(C)[C@H](N)C(=O)OCCOCn1cnc2c1nc(N)[nH]c2=O |r| Show InChI InChI=1S/C13H20N6O4/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20)/t8-/m0/s1 | PDB
Reactome pathway KEGG
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| Article PubMed
| 7.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical College of Georgia
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT1-expressing HeLa cells |
Biochem Biophys Res Commun 246: 470-5 (1998)
Article DOI: 10.1006/bbrc.1998.8628 BindingDB Entry DOI: 10.7270/Q2RR223Z |
More data for this Ligand-Target Pair | |
Solute carrier family 15 member 1
(Rattus norvegicus) | BDBM50162073
((S)-2-((2-amino-6-oxo-3H-purin-9(6H)-yl)methoxy)et...)Show SMILES CC(C)[C@H](N)C(=O)OCCOCn1cnc2c1nc(N)[nH]c2=O |r| Show InChI InChI=1S/C13H20N6O4/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20)/t8-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
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| 2.50E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT1-expressing LLC-PK1 cells |
J Pharmacol Exp Ther 291: 705-9 (1999)
BindingDB Entry DOI: 10.7270/Q29P34J8 |
More data for this Ligand-Target Pair | |
Solute carrier family 15 member 1
(Rattus norvegicus) | BDBM50162073
((S)-2-((2-amino-6-oxo-3H-purin-9(6H)-yl)methoxy)et...)Show SMILES CC(C)[C@H](N)C(=O)OCCOCn1cnc2c1nc(N)[nH]c2=O |r| Show InChI InChI=1S/C13H20N6O4/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20)/t8-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
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| PubMed
| 2.70E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT1-expressing LLC-PK1 cells |
J Pharmacol Exp Ther 291: 705-9 (1999)
BindingDB Entry DOI: 10.7270/Q29P34J8 |
More data for this Ligand-Target Pair | |
Oligopeptide transporter small intestine isoform
(Homo sapiens (Human)) | BDBM50162073
((S)-2-((2-amino-6-oxo-3H-purin-9(6H)-yl)methoxy)et...)Show SMILES CC(C)[C@H](N)C(=O)OCCOCn1cnc2c1nc(N)[nH]c2=O |r| Show InChI InChI=1S/C13H20N6O4/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20)/t8-/m0/s1 | PDB
Reactome pathway KEGG
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| Article PubMed
| 4.08E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
State University of New Jersey
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Gly-Sar uptake in Xenopus laevis oocytes |
Biochem Biophys Res Commun 250: 246-51 (1998)
Article DOI: 10.1006/bbrc.1998.9298 BindingDB Entry DOI: 10.7270/Q2X92CCB |
More data for this Ligand-Target Pair | |
Oligopeptide transporter small intestine isoform
(Homo sapiens (Human)) | BDBM50162073
((S)-2-((2-amino-6-oxo-3H-purin-9(6H)-yl)methoxy)et...)Show SMILES CC(C)[C@H](N)C(=O)OCCOCn1cnc2c1nc(N)[nH]c2=O |r| Show InChI InChI=1S/C13H20N6O4/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20)/t8-/m0/s1 | PDB
Reactome pathway KEGG
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Patents
Similars
| Article PubMed
| n/a | n/a | 1.42E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description Inhibition of human PEPT1-mediated [3H]Gly-Sar uptake in human HeLa cells |
J Med Chem 53: 624-32 (2010)
Article DOI: 10.1021/jm9011559 BindingDB Entry DOI: 10.7270/Q2251J90 |
More data for this Ligand-Target Pair | |
Oligopeptide transporter small intestine isoform
(Homo sapiens (Human)) | BDBM50162073
((S)-2-((2-amino-6-oxo-3H-purin-9(6H)-yl)methoxy)et...)Show SMILES CC(C)[C@H](N)C(=O)OCCOCn1cnc2c1nc(N)[nH]c2=O |r| Show InChI InChI=1S/C13H20N6O4/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20)/t8-/m0/s1 | PDB
Reactome pathway KEGG
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.31E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description Inhibitory concentration against [3H]glycylsarcosine uptake in HeLa cells expressing human Intestinal peptide transporter PepT1 |
J Med Chem 48: 1274-7 (2005)
Article DOI: 10.1021/jm049450i BindingDB Entry DOI: 10.7270/Q2348M46 |
More data for this Ligand-Target Pair | |
Oligopeptide transporter small intestine isoform
(Homo sapiens (Human)) | BDBM50162073
((S)-2-((2-amino-6-oxo-3H-purin-9(6H)-yl)methoxy)et...)Show SMILES CC(C)[C@H](N)C(=O)OCCOCn1cnc2c1nc(N)[nH]c2=O |r| Show InChI InChI=1S/C13H20N6O4/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20)/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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Patents
Similars
| PubMed
| n/a | n/a | 3.40E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Gly-Sar uptake, D-form (Gly-Sar: 20 uM) in PEPT1-expressing CHO cells |
Pharm Res 15: 1154-9 (1998)
BindingDB Entry DOI: 10.7270/Q2BC40M3 |
More data for this Ligand-Target Pair | |
Oligopeptide transporter small intestine isoform
(Homo sapiens (Human)) | BDBM50162073
((S)-2-((2-amino-6-oxo-3H-purin-9(6H)-yl)methoxy)et...)Show SMILES CC(C)[C@H](N)C(=O)OCCOCn1cnc2c1nc(N)[nH]c2=O |r| Show InChI InChI=1S/C13H20N6O4/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20)/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 4.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 20 uM) in PEPT1-expressing CHO cells |
Pharm Res 15: 1154-9 (1998)
BindingDB Entry DOI: 10.7270/Q2BC40M3 |
More data for this Ligand-Target Pair | |
Oligopeptide transporter small intestine isoform
(Homo sapiens (Human)) | BDBM50162073
((S)-2-((2-amino-6-oxo-3H-purin-9(6H)-yl)methoxy)et...)Show SMILES CC(C)[C@H](N)C(=O)OCCOCn1cnc2c1nc(N)[nH]c2=O |r| Show InChI InChI=1S/C13H20N6O4/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20)/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.10E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Gly-Sar uptake, L-form (Gly-Sar: 20 uM) in PEPT1-expressing CHO cells |
Pharm Res 15: 1154-9 (1998)
BindingDB Entry DOI: 10.7270/Q2BC40M3 |
More data for this Ligand-Target Pair | |