Found 13 hits for monomerid = 50118886 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Gamma-amino-N-butyrate transaminase
(Sus scrofa) | BDBM50118886
(4-Amino-hex-5-enoic acid | CHEMBL89598 | US1018980...)Show InChI InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9) | PDB MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| | 2.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Gamma-amino-N-butyrate transaminase
(Homo sapiens (Human)) | BDBM50118886
(4-Amino-hex-5-enoic acid | CHEMBL89598 | US1018980...)Show InChI InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| DrugBank PubMed
| 8.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Concentration dependent inactivation of Gamma-amino-N-butyrate transaminase |
J Med Chem 45: 4531-9 (2002)
BindingDB Entry DOI: 10.7270/Q2G1605T |
More data for this Ligand-Target Pair | |
Gamma-amino-N-butyrate transaminase
(Homo sapiens (Human)) | BDBM50118886
(4-Amino-hex-5-enoic acid | CHEMBL89598 | US1018980...)Show InChI InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| 3.20E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Inactivation of GABA-AT |
J Med Chem 55: 357-66 (2012)
Article DOI: 10.1021/jm201231w BindingDB Entry DOI: 10.7270/Q2QF8V1F |
More data for this Ligand-Target Pair | |
Gamma-amino-N-butyrate transaminase
(Sus scrofa) | BDBM50118886
(4-Amino-hex-5-enoic acid | CHEMBL89598 | US1018980...)Show InChI InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9) | PDB MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 3.20E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Tested for inhibitory activity of the compound against gamma-aminobutyric acid aminotransferase from pig brain |
J Med Chem 46: 5292-3 (2003)
Article DOI: 10.1021/jm034162s BindingDB Entry DOI: 10.7270/Q2C53K8H |
More data for this Ligand-Target Pair | |
Gamma-amino-N-butyrate transaminase
(Homo sapiens (Human)) | BDBM50118886
(4-Amino-hex-5-enoic acid | CHEMBL89598 | US1018980...)Show InChI InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| DrugBank US Patent
| 3.20E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
US Patent
| Assay Description Biochemical assays were performed using a Biotek Synergy H1 microplate reader. Prior to their evaluation, initial experiments were performed to confi... |
US Patent US10189807 (2019)
BindingDB Entry DOI: 10.7270/Q2C82CDG |
More data for this Ligand-Target Pair | |
Gamma-amino-N-butyrate transaminase
(Rattus norvegicus) | BDBM50118886
(4-Amino-hex-5-enoic acid | CHEMBL89598 | US1018980...)Show InChI InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.00E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Inhibition of rat GABA aminotransferase by modified Scott and Jacoby method |
Bioorg Med Chem 20: 5763-73 (2012)
Article DOI: 10.1016/j.bmc.2012.08.009 BindingDB Entry DOI: 10.7270/Q26H4JHH |
More data for this Ligand-Target Pair | |
Gamma-amino-N-butyrate transaminase
(Rattus norvegicus) | BDBM50118886
(4-Amino-hex-5-enoic acid | CHEMBL89598 | US1018980...)Show InChI InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.00E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University
Curated by ChEMBL
| Assay Description Inactivation of GABA-AT in rat brain homogenate |
J Med Chem 55: 357-66 (2012)
Article DOI: 10.1021/jm201231w BindingDB Entry DOI: 10.7270/Q2QF8V1F |
More data for this Ligand-Target Pair | |
4-aminobutyrate aminotransferase, mitochondrial
(Mus musculus) | BDBM50118886
(4-Amino-hex-5-enoic acid | CHEMBL89598 | US1018980...)Show InChI InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.97E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Jouf University
Curated by ChEMBL
| Assay Description Inhibition of GABA aminotransferase in mouse brain homogenates using GABA and alpha-ketoglutarate as substrates preincubated for 30 mins followed by ... |
Bioorg Med Chem Lett 29: 1825-1830 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.007 |
More data for this Ligand-Target Pair | |
Gamma-amino-N-butyrate transaminase
(Rattus norvegicus) | BDBM50118886
(4-Amino-hex-5-enoic acid | CHEMBL89598 | US1018980...)Show InChI InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 4.12E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of Rattus norvegicus (rat) brain gamma-amino butyrate aminotransferase using gamma-amino butyrate as substrate assessed as decrease in NAD... |
Citation and Details
Article DOI: 10.1007/s00044-012-0023-0 BindingDB Entry DOI: 10.7270/Q25H7K4T |
More data for this Ligand-Target Pair | |
Canalicular multispecific organic anion transporter 2
(Homo sapiens (Human)) | BDBM50118886
(4-Amino-hex-5-enoic acid | CHEMBL89598 | US1018980...)Show InChI InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ... |
Toxicol Sci 136: 216-41 (2013)
BindingDB Entry DOI: 10.7270/Q2JM2D2D |
More data for this Ligand-Target Pair | |
Bile salt export pump
(Homo sapiens (Human)) | BDBM50118886
(4-Amino-hex-5-enoic acid | CHEMBL89598 | US1018980...)Show InChI InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ... |
Toxicol Sci 136: 216-41 (2013)
BindingDB Entry DOI: 10.7270/Q2JM2D2D |
More data for this Ligand-Target Pair | |
Canalicular multispecific organic anion transporter 1
(Homo sapiens (Human)) | BDBM50118886
(4-Amino-hex-5-enoic acid | CHEMBL89598 | US1018980...)Show InChI InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9) | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and... |
Toxicol Sci 136: 216-41 (2013)
BindingDB Entry DOI: 10.7270/Q2JM2D2D |
More data for this Ligand-Target Pair | |
Multidrug resistance-associated protein 4
(Homo sapiens (Human)) | BDBM50118886
(4-Amino-hex-5-enoic acid | CHEMBL89598 | US1018980...)Show InChI InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and... |
Toxicol Sci 136: 216-41 (2013)
BindingDB Entry DOI: 10.7270/Q2JM2D2D |
More data for this Ligand-Target Pair | |