BDBM101536 CHEMBL3128043::US8530494, 203::US8530652, 114::US8530652, 63
SMILES: CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3nc(C)nc4ccsc34)[nH]nc2C1(C)C)c1ccccc1
InChI Key: InChIKey=AYCPARAPKDAOEN-LJQANCHMSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human)) | BDBM101536 (CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Curated by ChEMBL | Assay Description Binding affinity to N-terminal GST-tagged recombinant human PAK4 kinase domain expressed in Escherichia coli using KKRNRRLSVA as substrate preincubat... | J Med Chem 57: 1033-45 (2014) Article DOI: 10.1021/jm401768t BindingDB Entry DOI: 10.7270/Q2F47QNW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PAK 1/CDC42 (Homo sapiens (Human)) | BDBM101536 (CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Curated by ChEMBL | Assay Description Binding affinity to N-terminal His-6-tagged recombinant human PAK1 using peptide substrate | J Med Chem 57: 1033-45 (2014) Article DOI: 10.1021/jm401768t BindingDB Entry DOI: 10.7270/Q2F47QNW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human)) | BDBM101536 (CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | 20 | n/a | n/a | n/a | <3.90 | n/a | n/a | n/a | n/a |
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent | Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a... | US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PAK 1/CDC42 (Homo sapiens (Human)) | BDBM101536 (CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Curated by ChEMBL | Assay Description Binding affinity to N-terminal GST-His-tagged recombinant human PAK1 kinase domain expressed in Escherichia coli BL21 using KKRNRRLSVA as sustrate pr... | J Med Chem 57: 1033-45 (2014) Article DOI: 10.1021/jm401768t BindingDB Entry DOI: 10.7270/Q2F47QNW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human)) | BDBM101536 (CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Curated by ChEMBL | Assay Description Binding affinity to N-terminal His-6-tagged recombinant human PAK4 using peptide substrate | J Med Chem 57: 1033-45 (2014) Article DOI: 10.1021/jm401768t BindingDB Entry DOI: 10.7270/Q2F47QNW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human)) | BDBM101536 (CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Key Laboratory of Structure-Based Drug Design& Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Curated by ChEMBL | Assay Description Inhibition of PAK4 (unknown origin) using substrate S2 after 60 mins by HTRF assay | Bioorg Med Chem 25: 3500-3511 (2017) Article DOI: 10.1016/j.bmc.2017.04.047 BindingDB Entry DOI: 10.7270/Q21Z46VS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human)) | BDBM101536 (CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of full length human PAK4 using substrate S2 after 60 mins by HTRF assay | Eur J Med Chem 155: 197-209 (2018) Article DOI: 10.1016/j.ejmech.2018.05.051 BindingDB Entry DOI: 10.7270/Q2KD21GG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human)) | BDBM101536 (CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Key Laboratory of Structure-Based Drug Design& Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Curated by ChEMBL | Assay Description Inhibition of PAK4 (unknown origin) | Bioorg Med Chem 25: 3500-3511 (2017) Article DOI: 10.1016/j.bmc.2017.04.047 BindingDB Entry DOI: 10.7270/Q21Z46VS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human)) | BDBM101536 (CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of peptide substrate phosphorylation by epidermal growth factor receptor | Eur J Med Chem 131: 1-13 (2017) Article DOI: 10.1016/j.ejmech.2017.02.063 BindingDB Entry DOI: 10.7270/Q28G8NZC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human)) | BDBM101536 (CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal His6-tagged PAK4 expressed in bacterial expression system by pyruvate kinase/LDH enzyme coupled assay | Eur J Med Chem 131: 1-13 (2017) Article DOI: 10.1016/j.ejmech.2017.02.063 BindingDB Entry DOI: 10.7270/Q28G8NZC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK7/Cyclin H/MNAT1 (Homo sapiens (Human)) | BDBM101536 (CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Lebanese American University Curated by ChEMBL | Assay Description Inhibition of CDK7/cyclin H/MNAT1 (unknown origin) pre incubated up to 60 mins followed by substrate and ATP addition | J Med Chem 63: 7458-7474 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PAK 1/CDC42 (Homo sapiens (Human)) | BDBM101536 (CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of PAK1 (unknown origin) using S2 peptide as substrate | Eur J Med Chem 131: 1-13 (2017) Article DOI: 10.1016/j.ejmech.2017.02.063 BindingDB Entry DOI: 10.7270/Q28G8NZC | |||||||||||
More data for this Ligand-Target Pair |