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SMILES: COc1nn2c(csc2c1N(CC1CC1)C1CCOCC1)-c1c(OC)cc(C)cc1OC

InChI Key: InChIKey=NFRNPJQFEXIFTF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 101664   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM101664
PNG
(US8530504, 25)
Show SMILES COc1nn2c(csc2c1N(CC1CC1)C1CCOCC1)-c1c(OC)cc(C)cc1OC |(-5.22,-.94,;-4.45,.4,;-2.91,.4,;-2.01,-.85,;-.54,-.37,;.92,-.85,;1.83,.4,;.92,1.64,;-.54,1.17,;-2.01,1.64,;-2.41,3.13,;-3.9,3.53,;-4.29,5.02,;-3.9,6.51,;-5.38,6.11,;-1.32,4.22,;.17,3.82,;1.26,4.91,;.86,6.4,;-.63,6.8,;-1.72,5.71,;1.32,-2.33,;.23,-3.42,;-1.26,-3.03,;-2.35,-4.11,;.63,-4.91,;2.12,-5.31,;2.51,-6.8,;3.2,-4.22,;2.81,-2.73,;3.9,-1.64,;5.38,-2.04,)|
Show InChI InChI=1S/C24H31N3O4S/c1-15-11-19(28-2)21(20(12-15)29-3)18-14-32-24-22(23(30-4)25-27(18)24)26(13-16-5-6-16)17-7-9-31-10-8-17/h11-12,14,16-17H,5-10,13H2,1-4H3
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Similars
US Patent
n/an/a 43n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
A binding competition experiment with CRF was conducted by the SPA (GE Healthcare) method using a 96-well plate.

US Patent US8530504 (2013)


BindingDB Entry DOI: 10.7270/Q29885NS
More data for this
Ligand-Target Pair