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BDBM101667 US8530504, 29

SMILES: COCc1cc(OC)c(-c2csc3c(N(CC4CCC4)C4CCOC4)c(OC)nn23)c(OC)c1

InChI Key: InChIKey=VMFRALBGTGHBMX-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 101667   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM101667
PNG
(US8530504, 29)
Show SMILES COCc1cc(OC)c(-c2csc3c(N(CC4CCC4)C4CCOC4)c(OC)nn23)c(OC)c1 |(5.59,-5.01,;4.5,-6.1,;3.02,-5.7,;2.62,-4.21,;1.13,-3.81,;.73,-2.32,;-.76,-1.92,;-1.84,-3.01,;1.82,-1.23,;1.42,.25,;2.33,1.5,;1.42,2.74,;-.04,2.27,;-1.51,2.74,;-1.91,4.23,;-.82,5.32,;.67,4.92,;1.44,3.59,;2.77,4.36,;2,5.69,;-3.39,4.63,;-4.64,3.73,;-5.88,4.63,;-5.41,6.1,;-3.87,6.1,;-2.41,1.5,;-3.95,1.5,;-4.72,.17,;-1.51,.25,;-.04,.73,;3.31,-1.63,;4.4,-.54,;5.88,-.94,;3.71,-3.12,)|
Show InChI InChI=1S/C25H33N3O5S/c1-29-13-17-10-20(30-2)22(21(11-17)31-3)19-15-34-25-23(24(32-4)26-28(19)25)27(12-16-6-5-7-16)18-8-9-33-14-18/h10-11,15-16,18H,5-9,12-14H2,1-4H3
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Similars
US Patent
n/an/a 45n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
A binding competition experiment with CRF was conducted by the SPA (GE Healthcare) method using a 96-well plate.

US Patent US8530504 (2013)


BindingDB Entry DOI: 10.7270/Q29885NS
More data for this
Ligand-Target Pair