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BDBM101685 US8530504, 47

SMILES: CCOCc1cc(OC)c(-c2csc3c(N(CC4CCC4)C4CCOC4)c(OC)nn23)c(OC)c1

InChI Key: InChIKey=JAARDWAXBAVVEF-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 101685   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM101685
PNG
(US8530504, 47)
Show SMILES CCOCc1cc(OC)c(-c2csc3c(N(CC4CCC4)C4CCOC4)c(OC)nn23)c(OC)c1 |(6.1,-6.47,;4.62,-6.07,;3.53,-7.16,;2.04,-6.76,;1.64,-5.27,;2.73,-4.18,;2.33,-2.7,;3.42,-1.61,;4.91,-2.01,;.84,-2.3,;.44,-.81,;1.35,.44,;.44,1.68,;-1.02,1.21,;-2.48,1.68,;-2.88,3.17,;-4.37,3.57,;-4.77,5.06,;-4,6.39,;-5.33,7.16,;-6.1,5.83,;-1.79,4.26,;-2.27,5.72,;-1.02,6.63,;.22,5.72,;-.25,4.26,;-3.39,.44,;-4.93,.44,;-5.7,-.9,;-2.48,-.81,;-1.02,-.33,;-.25,-3.39,;-1.73,-2.99,;-2.82,-4.08,;.15,-4.87,)|
Show InChI InChI=1S/C26H35N3O5S/c1-5-33-14-18-11-21(30-2)23(22(12-18)31-3)20-16-35-26-24(25(32-4)27-29(20)26)28(13-17-7-6-8-17)19-9-10-34-15-19/h11-12,16-17,19H,5-10,13-15H2,1-4H3
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Similars
US Patent
n/an/a 32n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
A binding competition experiment with CRF was conducted by the SPA (GE Healthcare) method using a 96-well plate.

US Patent US8530504 (2013)


BindingDB Entry DOI: 10.7270/Q29885NS
More data for this
Ligand-Target Pair