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SMILES: COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(cn2)C(=O)N2CCN(C)CC2)c2nccnc12

InChI Key: InChIKey=RIMKDCPGPONIFA-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 102511   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM102511 (US8536175, 25) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(cn2)C(=O)N2CCN(C)CC2)c2nccnc12 |(10.4,-2.67,;8.86,-2.67,;8.09,-1.33,;8.85,,;8.09,1.33,;8.86,2.67,;8.09,4,;6.55,1.33,;5.78,2.67,;5.78,,;6.55,-1.33,;5.78,-2.67,;4.23,,;3.47,1.33,;1.93,1.33,;1.15,,;-.38,,;-1.15,1.33,;-1.15,-1.33,;-2.69,-1.33,;-3.47,,;-5,,;-5.78,-1.33,;-5,-2.67,;-3.47,-2.67,;-7.31,-1.33,;-8.08,-2.67,;-8.08,,;-7.31,1.33,;-8.08,2.67,;-9.63,2.67,;-10.39,4,;-10.39,1.33,;-9.63,,;1.93,-1.33,;1.15,-2.67,;1.93,-4,;3.47,-4,;4.23,-2.67,;3.47,-1.33,)| Show InChI InChI=1S/C28H26Cl2N6O4/c1-35-10-12-36(13-11-35)28(38)16-4-7-21(33-15-16)34-27(37)18-6-5-17(25-26(18)32-9-8-31-25)22-23(29)19(39-2)14-20(40-3)24(22)30/h4-9,14-15H,10-13H2,1-3H3,(H,33,34,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...				US Patent US8815901 (2014) BindingDB Entry DOI: 10.7270/Q2XG9PT8
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM102511 (US8536175, 25) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(cn2)C(=O)N2CCN(C)CC2)c2nccnc12 |(10.4,-2.67,;8.86,-2.67,;8.09,-1.33,;8.85,,;8.09,1.33,;8.86,2.67,;8.09,4,;6.55,1.33,;5.78,2.67,;5.78,,;6.55,-1.33,;5.78,-2.67,;4.23,,;3.47,1.33,;1.93,1.33,;1.15,,;-.38,,;-1.15,1.33,;-1.15,-1.33,;-2.69,-1.33,;-3.47,,;-5,,;-5.78,-1.33,;-5,-2.67,;-3.47,-2.67,;-7.31,-1.33,;-8.08,-2.67,;-8.08,,;-7.31,1.33,;-8.08,2.67,;-9.63,2.67,;-10.39,4,;-10.39,1.33,;-9.63,,;1.93,-1.33,;1.15,-2.67,;1.93,-4,;3.47,-4,;4.23,-2.67,;3.47,-1.33,)| Show InChI InChI=1S/C28H26Cl2N6O4/c1-35-10-12-36(13-11-35)28(38)16-4-7-21(33-15-16)34-27(37)18-6-5-17(25-26(18)32-9-8-31-25)22-23(29)19(39-2)14-20(40-3)24(22)30/h4-9,14-15H,10-13H2,1-3H3,(H,33,34,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Protein kinase activity measured by the microfluidic caliper method.				US Patent US8536175 (2013) BindingDB Entry DOI: 10.7270/Q27D2SSH
					More data for this Ligand-Target Pair