null

SMILES: COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ncc(CN(C)C)[nH]2)c2ncccc12

InChI Key: InChIKey=AILPSTKPMGDNML-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 102551   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM102551 (US8536175, 177) Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ncc(CN(C)C)[nH]2)c2ncccc12 |(7.42,4,;8.19,2.66,;7.42,1.33,;8.19,-0,;7.42,-1.34,;8.19,-2.67,;9.73,-2.67,;5.88,-1.34,;5.11,-2.67,;5.11,-0,;5.88,1.33,;5.11,2.66,;3.57,-0,;2.8,1.33,;1.26,1.33,;.49,-0,;-1.05,-0,;-1.82,1.33,;-1.82,-1.34,;-3.36,-1.34,;-4.27,-.09,;-5.73,-.57,;-5.73,-2.11,;-7.07,-2.88,;-8.4,-2.11,;-9.74,-2.88,;-8.4,-.57,;-4.27,-2.58,;1.26,-1.34,;.49,-2.67,;1.26,-4.01,;2.8,-4.01,;3.57,-2.67,;2.8,-1.34,)| Show InChI InChI=1S/C24H23ClFN5O3/c1-31(2)12-13-11-28-24(29-13)30-23(32)16-8-7-14(15-6-5-9-27-22(15)16)19-20(25)17(33-3)10-18(34-4)21(19)26/h5-11H,12H2,1-4H3,(H2,28,29,30,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Protein kinase activity measured by the microfluidic caliper method.				US Patent US8536175 (2013) BindingDB Entry DOI: 10.7270/Q27D2SSH
					More data for this Ligand-Target Pair