BDBM102619 K02288a::US10688093, Compound 382_0087_0284
SMILES: COc1cc(cc(OC)c1OC)-c1cc(cnc1N)-c1cccc(O)c1
InChI Key: InChIKey=CJLMANFTWLNAKC-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALK1 (Mus musculus) | BDBM102619 (K02288a | US10688093, Compound 382_0087_0284) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.65 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology | ACS Chem Biol 8: 1291-302 (2013) Article DOI: 10.1021/cb300655w BindingDB Entry DOI: 10.7270/Q2ZW1JKW | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK2 (Mus musculus) | BDBM102619 (K02288a | US10688093, Compound 382_0087_0284) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology | ACS Chem Biol 8: 1291-302 (2013) Article DOI: 10.1021/cb300655w BindingDB Entry DOI: 10.7270/Q2ZW1JKW | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
ALK3 (Mus musculus) | BDBM102619 (K02288a | US10688093, Compound 382_0087_0284) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 25.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology | ACS Chem Biol 8: 1291-302 (2013) Article DOI: 10.1021/cb300655w BindingDB Entry DOI: 10.7270/Q2ZW1JKW | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK4 (Mus musculus) | BDBM102619 (K02288a | US10688093, Compound 382_0087_0284) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 232 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology | ACS Chem Biol 8: 1291-302 (2013) Article DOI: 10.1021/cb300655w BindingDB Entry DOI: 10.7270/Q2ZW1JKW | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK5 (Mus musculus) | BDBM102619 (K02288a | US10688093, Compound 382_0087_0284) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 236 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology | ACS Chem Biol 8: 1291-302 (2013) Article DOI: 10.1021/cb300655w BindingDB Entry DOI: 10.7270/Q2ZW1JKW | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM102619 (K02288a | US10688093, Compound 382_0087_0284) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology Curated by ChEMBL | Assay Description Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P] | J Med Chem 57: 7900-15 (2014) Article DOI: 10.1021/jm501177w BindingDB Entry DOI: 10.7270/Q2PK0HS6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase Fyn (Homo sapiens (Human)) | BDBM102619 (K02288a | US10688093, Compound 382_0087_0284) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 526 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA US Patent | Assay Description The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the... | US Patent US10688093 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM102619 (K02288a | US10688093, Compound 382_0087_0284) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology Curated by ChEMBL | Assay Description Inhibition of TGFbeta1-induced TGFbeta type 1 ALK5 in HEK293T cells after 30 mins by luciferase reporter gene assay | J Med Chem 57: 7900-15 (2014) Article DOI: 10.1021/jm501177w BindingDB Entry DOI: 10.7270/Q2PK0HS6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK2 (Mus musculus) | BDBM102619 (K02288a | US10688093, Compound 382_0087_0284) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology Curated by ChEMBL | Assay Description Inhibition of BMP2-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assay | J Med Chem 57: 7900-15 (2014) Article DOI: 10.1021/jm501177w BindingDB Entry DOI: 10.7270/Q2PK0HS6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
ALK2 (Mus musculus) | BDBM102619 (K02288a | US10688093, Compound 382_0087_0284) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology Curated by ChEMBL | Assay Description Inhibition of BMP4-induced BMP receptor in mouse C2C12 cells after 30 mins by luciferase reporter gene assay | J Med Chem 57: 7900-15 (2014) Article DOI: 10.1021/jm501177w BindingDB Entry DOI: 10.7270/Q2PK0HS6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
ALK2 (Mus musculus) | BDBM102619 (K02288a | US10688093, Compound 382_0087_0284) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology Curated by ChEMBL | Assay Description Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assay | J Med Chem 57: 7900-15 (2014) Article DOI: 10.1021/jm501177w BindingDB Entry DOI: 10.7270/Q2PK0HS6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase Fyn (Homo sapiens (Human)) | BDBM102619 (K02288a | US10688093, Compound 382_0087_0284) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 723 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA US Patent | Assay Description The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the... | US Patent US10688093 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM102619 (K02288a | US10688093, Compound 382_0087_0284) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology Curated by ChEMBL | Assay Description Inhibition of purified human ALK5 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P] | J Med Chem 57: 7900-15 (2014) Article DOI: 10.1021/jm501177w BindingDB Entry DOI: 10.7270/Q2PK0HS6 | |||||||||||
More data for this Ligand-Target Pair |