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SMILES: COC(=O)N[C@@H](C)CNc1nccc(n1)-c1nc([nH]c1-c1cccc(NS(C)(=O)=O)c1Cl)C1CC1

InChI Key: InChIKey=QYXRSOAMFKXRCU-LBPRGKRZSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 103643   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase B-raf [V600E]


(Homo sapiens (Human))		BDBM103643
PNG
(US8563553, 68)
Show SMILES COC(=O)N[C@@H](C)CNc1nccc(n1)-c1nc([nH]c1-c1cccc(NS(C)(=O)=O)c1Cl)C1CC1 |r|
Show InChI InChI=1S/C22H26ClN7O4S/c1-12(26-22(31)34-2)11-25-21-24-10-9-16(27-21)19-18(28-20(29-19)13-7-8-13)14-5-4-6-15(17(14)23)30-35(3,32)33/h4-6,9-10,12-13,30H,7-8,11H2,1-3H3,(H,26,31)(H,28,29)(H,24,25,27)/t12-/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.470n/an/an/an/a7.5n/a



Novartis AG; IRM LLC

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.

US Patent US8563553 (2013)


BindingDB Entry DOI: 10.7270/Q2ZP44R7
More data for this
Ligand-Target Pair