BDBM103673 US8563553, 98

SMILES: COC(=O)N[C@@H](C)CNc1nccc(n1)-c1nc([nH]c1-c1cc(Cl)cc(NS(=O)(=O)c2cccc(F)c2)c1F)C1CC1

InChI Key: InChIKey=FAGJFBOKLUFLLZ-AWEZNQCLSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 103673   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human))	BDBM103673 (US8563553, 98) Show SMILES COC(=O)N[C@@H](C)CNc1nccc(n1)-c1nc([nH]c1-c1cc(Cl)cc(NS(=O)(=O)c2cccc(F)c2)c1F)C1CC1 |r| Show InChI InChI=1S/C27H26ClF2N7O4S/c1-14(33-27(38)41-2)13-32-26-31-9-8-20(34-26)24-23(35-25(36-24)15-6-7-15)19-10-16(28)11-21(22(19)30)37-42(39,40)18-5-3-4-17(29)12-18/h3-5,8-12,14-15,37H,6-7,13H2,1-2H3,(H,33,38)(H,35,36)(H,31,32,34)/t14-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.330	n/a	n/a	n/a	n/a	7.5	n/a
Novartis AG; IRM LLC US Patent					Assay Description Raf/Mek amplified luminescence proximity homogeneous assay.				US Patent US8563553 (2013) BindingDB Entry DOI: 10.7270/Q2ZP44R7
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