BDBM103737 US10206907, Compound 234::US8563545, 11
SMILES: FC1(F)CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1
InChI Key: InChIKey=PFKFICBDHPHHLW-UHFFFAOYSA-N
Data: 14 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM103737 (US10206907, Compound 234 | US11000528, Cpd # 11 | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 7.69 | n/a | n/a | n/a | n/a | n/a | n/a |
Galapagos NV US Patent | Assay Description In vitro inhibition assay using various enzyme. | US Patent US8563545 (2013) BindingDB Entry DOI: 10.7270/Q2TX3D1X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM103737 (US10206907, Compound 234 | US11000528, Cpd # 11 | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 15.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Galapagos NV US Patent | Assay Description In vitro inhibition assay using various enzyme. | US Patent US8563545 (2013) BindingDB Entry DOI: 10.7270/Q2TX3D1X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM103737 (US10206907, Compound 234 | US11000528, Cpd # 11 | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 195 | n/a | n/a | n/a | n/a | n/a | n/a |
Galapagos NV US Patent | Assay Description In vitro inhibition assay using various enzyme. | US Patent US8563545 (2013) BindingDB Entry DOI: 10.7270/Q2TX3D1X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM103737 (US10206907, Compound 234 | US11000528, Cpd # 11 | ...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
Galapagos NV US Patent | Assay Description In vitro inhibition assay using various enzyme. | US Patent US8563545 (2013) BindingDB Entry DOI: 10.7270/Q2TX3D1X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM103737 (US10206907, Compound 234 | US11000528, Cpd # 11 | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Galapagos NV Curated by ChEMBL | Assay Description Inhibition of JAK2 in human whole blood assessed as inhibition of GM-CSF-induced pSTAT5 | J Med Chem 57: 9323-42 (2014) Article DOI: 10.1021/jm501262q BindingDB Entry DOI: 10.7270/Q2GH9KK6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM103737 (US10206907, Compound 234 | US11000528, Cpd # 11 | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Galapagos NV Curated by ChEMBL | Assay Description Inhibition of JAK1 in human whole blood assessed as inhibition of IL-6-induced pSTAT1 | J Med Chem 57: 9323-42 (2014) Article DOI: 10.1021/jm501262q BindingDB Entry DOI: 10.7270/Q2GH9KK6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TYK2 (aa 871-1187) (Homo sapiens (Human)) | BDBM103737 (US10206907, Compound 234 | US11000528, Cpd # 11 | ...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
GALAPAGOS NV US Patent | Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate... | US Patent US11000528 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
JAK2 (aa 808-1132) (Homo sapiens (Human)) | BDBM103737 (US10206907, Compound 234 | US11000528, Cpd # 11 | ...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
GALAPAGOS NV US Patent | Assay Description Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w... | US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
JAK3 (aa 781-1124) (Homo sapiens (Human)) | BDBM103737 (US10206907, Compound 234 | US11000528, Cpd # 11 | ...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
GALAPAGOS NV US Patent | Assay Description Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w... | US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
JAK1 (aa 850-1154) (Homo sapiens (Human)) | BDBM103737 (US10206907, Compound 234 | US11000528, Cpd # 11 | ...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
GALAPAGOS NV US Patent | Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat... | US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 (850-1154) () | BDBM103737 (US10206907, Compound 234 | US11000528, Cpd # 11 | ...) | PDB MMDB B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 7.69 | n/a | n/a | n/a | n/a | n/a | n/a |
GALAPAGOS NV US Patent | Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat... | US Patent US11000528 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM103737 (US10206907, Compound 234 | US11000528, Cpd # 11 | ...) | PDB MMDB B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 15.5 | n/a | n/a | n/a | n/a | n/a | n/a |
GALAPAGOS NV US Patent | Assay Description Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w... | US Patent US11000528 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
JAK3 (aa 781-1124) (Homo sapiens (Human)) | BDBM103737 (US10206907, Compound 234 | US11000528, Cpd # 11 | ...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 195 | n/a | n/a | n/a | n/a | n/a | n/a |
GALAPAGOS NV US Patent | Assay Description Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w... | US Patent US11000528 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM103737 (US10206907, Compound 234 | US11000528, Cpd # 11 | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Galapagos NV Curated by ChEMBL | Assay Description Inhibition of human recombinant JAK1 | J Med Chem 57: 9323-42 (2014) Article DOI: 10.1021/jm501262q BindingDB Entry DOI: 10.7270/Q2GH9KK6 | |||||||||||
More data for this Ligand-Target Pair |