BDBM103845 4HQ derivative 8
SMILES: CCCCCCCc1nc(C(=O)NCC(O)=O)c(O)c2ccccc12
InChI Key: InChIKey=VDEUJVUTGALZBR-UHFFFAOYSA-N
Data: 7 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Jumonji domain-containing protein 2A (JMJD2A) (Homo sapiens (Human)) | BDBM103845 (4HQ derivative 8) | PDB MMDB B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.30E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Oxford | Assay Description Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o... | ACS Chem Biol 8: 1488-96 (2013) Article DOI: 10.1021/cb400088q BindingDB Entry DOI: 10.7270/Q29Z93HF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone Lysine Demethylase (Homo sapiens (Human)) | BDBM103845 (4HQ derivative 8) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.90E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Oxford | Assay Description Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o... | ACS Chem Biol 8: 1488-96 (2013) Article DOI: 10.1021/cb400088q BindingDB Entry DOI: 10.7270/Q29Z93HF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM103845 (4HQ derivative 8) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Oxford | Assay Description Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o... | ACS Chem Biol 8: 1488-96 (2013) Article DOI: 10.1021/cb400088q BindingDB Entry DOI: 10.7270/Q29Z93HF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Jumonji domain-containing protein 2C (JMJD2C) (Homo sapiens (Human)) | BDBM103845 (4HQ derivative 8) | PDB MMDB Reactome pathway B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.60E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Oxford | Assay Description Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o... | ACS Chem Biol 8: 1488-96 (2013) Article DOI: 10.1021/cb400088q BindingDB Entry DOI: 10.7270/Q29Z93HF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Homo sapiens lysine demethylase 2A (KDM2A) (Homo sapiens (Human)) | BDBM103845 (4HQ derivative 8) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Oxford | Assay Description Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o... | ACS Chem Biol 8: 1488-96 (2013) Article DOI: 10.1021/cb400088q BindingDB Entry DOI: 10.7270/Q29Z93HF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5C (Homo sapiens (Human)) | BDBM103845 (4HQ derivative 8) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.23E+5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Oxford | Assay Description Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o... | ACS Chem Biol 8: 1488-96 (2013) Article DOI: 10.1021/cb400088q BindingDB Entry DOI: 10.7270/Q29Z93HF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 3A (Homo sapiens (Human)) | BDBM103845 (4HQ derivative 8) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Oxford | Assay Description Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o... | ACS Chem Biol 8: 1488-96 (2013) Article DOI: 10.1021/cb400088q BindingDB Entry DOI: 10.7270/Q29Z93HF | |||||||||||
More data for this Ligand-Target Pair |