BDBM103919 US8569511, 3

SMILES: O=C(Nc1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCOCC3)c2c1)C1CC1

InChI Key: InChIKey=LHZVIFNUNXWEFW-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 103919   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3-phosphoinositide dependent protein kinase-1 (Homo sapiens (Human))	BDBM103919 (US8569511, 3) Show SMILES O=C(Nc1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCOCC3)c2c1)C1CC1 Show InChI InChI=1S/C22H22N6O2/c29-22(13-1-2-13)23-14-3-5-17-16(11-14)20(27-26-17)21-24-18-6-4-15(12-19(18)25-21)28-7-9-30-10-8-28/h3-6,11-13H,1-2,7-10H2,(H,23,29)(H,24,25)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	283	n/a	n/a	n/a	n/a	n/a	n/a
University of Utah Research Foundation US Patent					Assay Description The primary assay for compound inhibitory activity was the ATP depletion assay using the PDKtide substrate purchase from Millipore Corporation.				US Patent US8569511 (2013) BindingDB Entry DOI: 10.7270/Q2T1528Q
					More data for this Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1 (Homo sapiens (Human))	BDBM103919 (US8569511, 3) Show SMILES O=C(Nc1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCOCC3)c2c1)C1CC1 Show InChI InChI=1S/C22H22N6O2/c29-22(13-1-2-13)23-14-3-5-17-16(11-14)20(27-26-17)21-24-18-6-4-15(12-19(18)25-21)28-7-9-30-10-8-28/h3-6,11-13H,1-2,7-10H2,(H,23,29)(H,24,25)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Brigham Young University Curated by ChEMBL					Assay Description Inhibition of PDK1 (unknown origin) after 1 hr in presence of Ser/Thr-07 by fluorometric assay				Bioorg Med Chem Lett 27: 5473-5480 (2017) Article DOI: 10.1016/j.bmcl.2017.10.041 BindingDB Entry DOI: 10.7270/Q2KD21JC
					More data for this Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1 (Homo sapiens (Human))	BDBM103919 (US8569511, 3) Show SMILES O=C(Nc1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCOCC3)c2c1)C1CC1 Show InChI InChI=1S/C22H22N6O2/c29-22(13-1-2-13)23-14-3-5-17-16(11-14)20(27-26-17)21-24-18-6-4-15(12-19(18)25-21)28-7-9-30-10-8-28/h3-6,11-13H,1-2,7-10H2,(H,23,29)(H,24,25)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	229	n/a	n/a	n/a	n/a	n/a	n/a
University of Utah Research Foundation US Patent					Assay Description The secondary assay was a time resolved-FRET LanthaScreen Kinase Binding Assay. (Invitrogen Corporation, Carlsbad, Calif.). This assay evaluates the...				US Patent US8569511 (2013) BindingDB Entry DOI: 10.7270/Q2T1528Q
					More data for this Ligand-Target Pair