Found 5 hits for monomerid = 103939 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
3-phosphoinositide dependent protein kinase-1
(Homo sapiens (Human)) | BDBM103939
(US8569511, 2)Show SMILES CC1CN(CCO1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccc(NC(=O)C3CC3(F)F)cc12 Show InChI InChI=1S/C23H22F2N6O2/c1-12-11-31(6-7-33-12)14-3-5-18-19(9-14)28-21(27-18)20-15-8-13(2-4-17(15)29-30-20)26-22(32)16-10-23(16,24)25/h2-5,8-9,12,16H,6-7,10-11H2,1H3,(H,26,32)(H,27,28)(H,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 159 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Utah Research Foundation
US Patent
| Assay Description The primary assay for compound inhibitory activity was the ATP depletion assay using the PDKtide substrate purchase from Millipore Corporation. |
US Patent US8569511 (2013)
BindingDB Entry DOI: 10.7270/Q2T1528Q |
More data for this Ligand-Target Pair | |
3-phosphoinositide dependent protein kinase-1
(Homo sapiens (Human)) | BDBM103939
(US8569511, 2)Show SMILES CC1CN(CCO1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccc(NC(=O)C3CC3(F)F)cc12 Show InChI InChI=1S/C23H22F2N6O2/c1-12-11-31(6-7-33-12)14-3-5-18-19(9-14)28-21(27-18)20-15-8-13(2-4-17(15)29-30-20)26-22(32)16-10-23(16,24)25/h2-5,8-9,12,16H,6-7,10-11H2,1H3,(H,26,32)(H,27,28)(H,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 94 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Utah Research Foundation
US Patent
| Assay Description The secondary assay was a time resolved-FRET LanthaScreen Kinase Binding Assay. (Invitrogen Corporation, Carlsbad, Calif.). This assay evaluates the... |
US Patent US8569511 (2013)
BindingDB Entry DOI: 10.7270/Q2T1528Q |
More data for this Ligand-Target Pair | |
3-phosphoinositide dependent protein kinase-1
(Homo sapiens (Human)) | BDBM103939
(US8569511, 2)Show SMILES CC1CN(CCO1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccc(NC(=O)C3CC3(F)F)cc12 Show InChI InChI=1S/C23H22F2N6O2/c1-12-11-31(6-7-33-12)14-3-5-18-19(9-14)28-21(27-18)20-15-8-13(2-4-17(15)29-30-20)26-22(32)16-10-23(16,24)25/h2-5,8-9,12,16H,6-7,10-11H2,1H3,(H,26,32)(H,27,28)(H,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 77 | n/a | n/a | n/a | n/a |
Brigham Young University
Curated by ChEMBL
| Assay Description Inhibition of PDK1 mediated PI3K/Akt/mTOR pathway activation in human AN3CA cells assessed as reduction in ribosomal p70S6 protein phosphorylation af... |
Bioorg Med Chem Lett 27: 5473-5480 (2017)
Article DOI: 10.1016/j.bmcl.2017.10.041 BindingDB Entry DOI: 10.7270/Q2KD21JC |
More data for this Ligand-Target Pair | |
3-phosphoinositide dependent protein kinase-1
(Homo sapiens (Human)) | BDBM103939
(US8569511, 2)Show SMILES CC1CN(CCO1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccc(NC(=O)C3CC3(F)F)cc12 Show InChI InChI=1S/C23H22F2N6O2/c1-12-11-31(6-7-33-12)14-3-5-18-19(9-14)28-21(27-18)20-15-8-13(2-4-17(15)29-30-20)26-22(32)16-10-23(16,24)25/h2-5,8-9,12,16H,6-7,10-11H2,1H3,(H,26,32)(H,27,28)(H,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham Young University
Curated by ChEMBL
| Assay Description Inhibition of PDK1 (unknown origin) after 1 hr in presence of Ser/Thr-07 by fluorometric assay |
Bioorg Med Chem Lett 27: 5473-5480 (2017)
Article DOI: 10.1016/j.bmcl.2017.10.041 BindingDB Entry DOI: 10.7270/Q2KD21JC |
More data for this Ligand-Target Pair | |
3-phosphoinositide dependent protein kinase-1
(Homo sapiens (Human)) | BDBM103939
(US8569511, 2)Show SMILES CC1CN(CCO1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccc(NC(=O)C3CC3(F)F)cc12 Show InChI InChI=1S/C23H22F2N6O2/c1-12-11-31(6-7-33-12)14-3-5-18-19(9-14)28-21(27-18)20-15-8-13(2-4-17(15)29-30-20)26-22(32)16-10-23(16,24)25/h2-5,8-9,12,16H,6-7,10-11H2,1H3,(H,26,32)(H,27,28)(H,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 94 | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham Young University
Curated by ChEMBL
| Assay Description Inhibition of PDK1 (unknown origin) by TR-FRET assay |
Bioorg Med Chem Lett 27: 5473-5480 (2017)
Article DOI: 10.1016/j.bmcl.2017.10.041 BindingDB Entry DOI: 10.7270/Q2KD21JC |
More data for this Ligand-Target Pair | |