BDBM104215 US8575145, 152::US8575145, 92::US8575145, 92/122

SMILES: Cc1ccn2c(nnc2c1)-c1ccc2cccc(OC3CCNCCC3F)c2n1

InChI Key: InChIKey=KOQXLXUOIGXSIW-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 104215   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104215 (US8575145, 152 | US8575145, 92 | US8575145, 92/122) Show SMILES Cc1ccn2c(nnc2c1)-c1ccc2cccc(OC3CCNCCC3F)c2n1 Show InChI InChI=1S/C22H22FN5O/c1-14-9-12-28-20(13-14)26-27-22(28)17-6-5-15-3-2-4-19(21(15)25-17)29-18-8-11-24-10-7-16(18)23/h2-6,9,12-13,16,18,24H,7-8,10-11H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17.5	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104215 (US8575145, 152 | US8575145, 92 | US8575145, 92/122) Show SMILES Cc1ccn2c(nnc2c1)-c1ccc2cccc(OC3CCNCCC3F)c2n1 Show InChI InChI=1S/C22H22FN5O/c1-14-9-12-28-20(13-14)26-27-22(28)17-6-5-15-3-2-4-19(21(15)25-17)29-18-8-11-24-10-7-16(18)23/h2-6,9,12-13,16,18,24H,7-8,10-11H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PIM-3 (Rattus norvegicus (Rat))	BDBM104215 (US8575145, 152 | US8575145, 92 | US8575145, 92/122) Show SMILES Cc1ccn2c(nnc2c1)-c1ccc2cccc(OC3CCNCCC3F)c2n1 Show InChI InChI=1S/C22H22FN5O/c1-14-9-12-28-20(13-14)26-27-22(28)17-6-5-15-3-2-4-19(21(15)25-17)29-18-8-11-24-10-7-16(18)23/h2-6,9,12-13,16,18,24H,7-8,10-11H2,1H3	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	23.5	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM104215 (US8575145, 152 | US8575145, 92 | US8575145, 92/122) Show SMILES Cc1ccn2c(nnc2c1)-c1ccc2cccc(OC3CCNCCC3F)c2n1 Show InChI InChI=1S/C22H22FN5O/c1-14-9-12-28-20(13-14)26-27-22(28)17-6-5-15-3-2-4-19(21(15)25-17)29-18-8-11-24-10-7-16(18)23/h2-6,9,12-13,16,18,24H,7-8,10-11H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PIM-3 (Rattus norvegicus (Rat))	BDBM104215 (US8575145, 152 | US8575145, 92 | US8575145, 92/122) Show SMILES Cc1ccn2c(nnc2c1)-c1ccc2cccc(OC3CCNCCC3F)c2n1 Show InChI InChI=1S/C22H22FN5O/c1-14-9-12-28-20(13-14)26-27-22(28)17-6-5-15-3-2-4-19(21(15)25-17)29-18-8-11-24-10-7-16(18)23/h2-6,9,12-13,16,18,24H,7-8,10-11H2,1H3	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM104215 (US8575145, 152 | US8575145, 92 | US8575145, 92/122) Show SMILES Cc1ccn2c(nnc2c1)-c1ccc2cccc(OC3CCNCCC3F)c2n1 Show InChI InChI=1S/C22H22FN5O/c1-14-9-12-28-20(13-14)26-27-22(28)17-6-5-15-3-2-4-19(21(15)25-17)29-18-8-11-24-10-7-16(18)23/h2-6,9,12-13,16,18,24H,7-8,10-11H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	244	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair