BDBM105367 US8575203, I-125.9

SMILES: CN1CC[C@H](COc2ccnc3ccc(cc23)C#CCNC(=O)c2cccn(Cc3cc(F)c(F)c(F)c3)c2=O)C1

InChI Key: InChIKey=HDJRUXNOZPZNHS-NRFANRHFSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 105367   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3-phosphoinositide dependent protein kinase-1 (Homo sapiens (Human))	BDBM105367 (US8575203, I-125.9) Show SMILES CN1CC[C@H](COc2ccnc3ccc(cc23)C#CCNC(=O)c2cccn(Cc3cc(F)c(F)c(F)c3)c2=O)C1 |r| Show InChI InChI=1S/C31H27F3N4O3/c1-37-13-9-21(17-37)19-41-28-8-11-35-27-7-6-20(14-24(27)28)4-2-10-36-30(39)23-5-3-12-38(31(23)40)18-22-15-25(32)29(34)26(33)16-22/h3,5-8,11-12,14-16,21H,9-10,13,17-19H2,1H3,(H,36,39)/t21-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The activity of the compounds according to the invention on the kinase PDK1 which inhibits the signal transduction pathway is determined in an in vit...				US Patent US8575203 (2013) BindingDB Entry DOI: 10.7270/Q2HD7T91
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