BDBM106769 1‐benzyl‐2‐phenyl‐1,3‐benzodiazole (B10)

SMILES: C(c1ccccc1)n1c(nc2ccccc12)-c1ccccc1

InChI Key: InChIKey=LCFXRSKBJWQHON-UHFFFAOYSA-N

Data: 1 IC50  3 Kd

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 106769   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Xanthine dehydrogenase (Bos taurus (Bovine))	BDBM106769 (1‐benzyl‐2‐phenyl‐1,3̴...) Show SMILES C(c1ccccc1)n1c(nc2ccccc12)-c1ccccc1 Show InChI InChI=1S/C20H16N2/c1-3-9-16(10-4-1)15-22-19-14-8-7-13-18(19)21-20(22)17-11-5-2-6-12-17/h1-14H,15H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	9.70E+3	n/a	n/a	n/a	n/a	7.6	25
Konkuk University					Assay Description Bovine milk XO activity was assayed spectrophotometrically by measuring the uric acid formation at 293 nm using a UV-visible spectrophotometer at 25&...				Chem Biol Drug Des 82: 290-5 (2013) Article DOI: 10.1111/cbdd.12141 BindingDB Entry DOI: 10.7270/Q2TM78SJ
					More data for this Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (Homo sapiens (Human))	BDBM106769 (1‐benzyl‐2‐phenyl‐1,3̴...) Show SMILES C(c1ccccc1)n1c(nc2ccccc12)-c1ccccc1 Show InChI InChI=1S/C20H16N2/c1-3-9-16(10-4-1)15-22-19-14-8-7-13-18(19)21-20(22)17-11-5-2-6-12-17/h1-14H,15H2	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	165	n/a	n/a	n/a	n/a	n/a
School of Pharmacy , Second Military Medical University , 325 Guohe Road , Shanghai 200433 , China. Curated by ChEMBL					Assay Description Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasma				J Med Chem 61: 2604-2610 (2018) Article DOI: 10.1021/acs.jmedchem.8b00057 BindingDB Entry DOI: 10.7270/Q2CZ39MM
					More data for this Ligand-Target Pair				3D Structure (crystal)
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (Homo sapiens (Human))	BDBM106769 (1‐benzyl‐2‐phenyl‐1,3̴...) Show SMILES C(c1ccccc1)n1c(nc2ccccc12)-c1ccccc1 Show InChI InChI=1S/C20H16N2/c1-3-9-16(10-4-1)15-22-19-14-8-7-13-18(19)21-20(22)17-11-5-2-6-12-17/h1-14H,15H2	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a
Max Planck Institute of Molecular Physiology Curated by ChEMBL					Assay Description Binding affinity to PDE-delta (unknown origin) by SPR analysis				J Med Chem 57: 5435-48 (2014) Article DOI: 10.1021/jm500632s BindingDB Entry DOI: 10.7270/Q24Q7WJP
					More data for this Ligand-Target Pair				3D Structure (crystal)
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (Homo sapiens (Human))	BDBM106769 (1‐benzyl‐2‐phenyl‐1,3̴...) Show SMILES C(c1ccccc1)n1c(nc2ccccc12)-c1ccccc1 Show InChI InChI=1S/C20H16N2/c1-3-9-16(10-4-1)15-22-19-14-8-7-13-18(19)21-20(22)17-11-5-2-6-12-17/h1-14H,15H2	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a
Max Planck Institute of Molecular Physiology Curated by ChEMBL					Assay Description Binding affinity to PDE-delta (unknown origin) by time-resolved fluorescence anisotropic analysis				J Med Chem 57: 5435-48 (2014) Article DOI: 10.1021/jm500632s BindingDB Entry DOI: 10.7270/Q24Q7WJP
					More data for this Ligand-Target Pair				3D Structure (crystal)