BDBM107366 US8592431, 167

SMILES: CCCc1c(Cc2ccc(cc2F)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@H](O)CC2)c2ncnn12

InChI Key: InChIKey=CVDPCPAIFZILGD-MXVIHJGJSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 107366   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Acetyl-coenzyme A transporter 1 (AT1) (Homo sapiens (Human))	BDBM107366 (US8592431, 167) Show SMILES CCCc1c(Cc2ccc(cc2F)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@H](O)CC2)c2ncnn12 |r,wU:28.30,wD:31.34,(-4.67,2.44,;-3.33,3.21,;-2,2.44,;-.67,3.21,;.67,2.44,;.67,.9,;-.67,.13,;-2,.9,;-3.33,.13,;-3.33,-1.41,;-2,-2.18,;-.67,-1.41,;.67,-2.18,;-4.67,-2.18,;-6,-1.41,;-7.34,-2.18,;-7.34,-3.72,;-6,-4.49,;-4.67,-3.72,;-3.33,-4.49,;-3.33,-6.03,;-1.87,-6.5,;-1.1,-7.83,;-.96,-5.26,;-1.87,-4.01,;2,3.21,;3.33,2.44,;2,4.75,;3.33,5.52,;3.33,7.06,;4.67,7.83,;6,7.06,;7.34,7.83,;6,5.52,;4.67,4.75,;.67,5.52,;.35,7.03,;-1.18,7.19,;-1.81,5.79,;-.67,4.75,)| Show InChI InChI=1S/C29H29FN6O4/c1-2-5-25-23(27(38)35(28-31-16-32-36(25)28)19-10-12-20(37)13-11-19)14-18-9-8-17(15-24(18)30)21-6-3-4-7-22(21)26-33-29(39)40-34-26/h3-4,6-9,15-16,19-20,37H,2,5,10-14H2,1H3,(H,33,34,39)/t19-,20-	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.4	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...				US Patent US8592431 (2013) BindingDB Entry DOI: 10.7270/Q2H70DGX
					More data for this Ligand-Target Pair