BDBM10742 1-amino-2,3-dihydro-1H-inden-4-yl N,N-dimethylcarbamate::Aminoindan deriv. 13a

SMILES: CN(C)C(=O)Oc1cccc2C(N)CCc12

InChI Key: InChIKey=JHNADFDOHHLJBW-UHFFFAOYSA-N

Data: 4 IC50

PDB links: 1 PDB ID contains this monomer as substructures.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 10742   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Acetylcholinesterase (Homo sapiens (Human))	BDBM10742 (1-amino-2,3-dihydro-1H-inden-4-yl N,N-dimethylcarb...) Show SMILES CN(C)C(=O)Oc1cccc2C(N)CCc12 Show InChI InChI=1S/C12H16N2O2/c1-14(2)12(15)16-11-5-3-4-8-9(11)6-7-10(8)13/h3-5,10H,6-7,13H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Teva Pharmaceutical Industries					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...				J Med Chem 45: 5260-79 (2002) Article DOI: 10.1021/jm020120c BindingDB Entry DOI: 10.7270/Q2GQ6W07
					More data for this Ligand-Target Pair
Monoamine Oxidase Type B (MAO-B) (Rattus norvegicus (rat))	BDBM10742 (1-amino-2,3-dihydro-1H-inden-4-yl N,N-dimethylcarb...) Show SMILES CN(C)C(=O)Oc1cccc2C(N)CCc12 Show InChI InChI=1S/C12H16N2O2/c1-14(2)12(15)16-11-5-3-4-8-9(11)6-7-10(8)13/h3-5,10H,6-7,13H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Teva Pharmaceutical Industries					Assay Description Inhibition of MAO activity was determined by a radiometric procedure from Tipton and Youdim. Homogenized rat brain was used as the source of enzymes....				J Med Chem 45: 5260-79 (2002) Article DOI: 10.1021/jm020120c BindingDB Entry DOI: 10.7270/Q2GQ6W07
					More data for this Ligand-Target Pair
Monoamine oxidase (Rattus norvegicus (rat))	BDBM10742 (1-amino-2,3-dihydro-1H-inden-4-yl N,N-dimethylcarb...) Show SMILES CN(C)C(=O)Oc1cccc2C(N)CCc12 Show InChI InChI=1S/C12H16N2O2/c1-14(2)12(15)16-11-5-3-4-8-9(11)6-7-10(8)13/h3-5,10H,6-7,13H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Teva Pharmaceutical Industries					Assay Description Inhibition of MAO activity was determined by a radiometric procedure from Tipton and Youdim. Homogenized rat brain was used as the source of enzymes....				J Med Chem 45: 5260-79 (2002) Article DOI: 10.1021/jm020120c BindingDB Entry DOI: 10.7270/Q2GQ6W07
					More data for this Ligand-Target Pair
Butyrylcholinesterase (BChE) (Equus caballus (Horse))	BDBM10742 (1-amino-2,3-dihydro-1H-inden-4-yl N,N-dimethylcarb...) Show SMILES CN(C)C(=O)Oc1cccc2C(N)CCc12 Show InChI InChI=1S/C12H16N2O2/c1-14(2)12(15)16-11-5-3-4-8-9(11)6-7-10(8)13/h3-5,10H,6-7,13H2,1-2H3	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Teva Pharmaceutical Industries					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...				J Med Chem 45: 5260-79 (2002) Article DOI: 10.1021/jm020120c BindingDB Entry DOI: 10.7270/Q2GQ6W07
					More data for this Ligand-Target Pair