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SMILES: O=C(c1nc2nc(ccc2[nH]1)N1CCNCC1)c1ccnc(c1)-c1cncc2ccccc12

InChI Key: InChIKey=WPTQTLKVJWJUIC-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 107757   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cyclin-dependent kinase 4


(Oryctolagus cuniculus (Rabbit))		BDBM107757
PNG
(US8598217, 164)
Show SMILES O=C(c1nc2nc(ccc2[nH]1)N1CCNCC1)c1ccnc(c1)-c1cncc2ccccc12
Show InChI InChI=1S/C25H21N7O/c33-23(25-29-20-5-6-22(30-24(20)31-25)32-11-9-26-10-12-32)16-7-8-28-21(13-16)19-15-27-14-17-3-1-2-4-18(17)19/h1-8,13-15,26H,9-12H2,(H,29,30,31)
UniProtKB/TrEMBL

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Similars
US Patent
n/an/a 24n/an/an/an/a7.5n/a



Astex Therapeutics Ltd.; Novartis AG

US Patent


Assay Description
A 384-well microtiter Lance TR-FRET (time-resolved-fluorescence energy transfer) endpoint assay was used for CDK4/cyclin D1 kinase activity measureme...

US Patent US8598217 (2013)


BindingDB Entry DOI: 10.7270/Q2BG2MN8
More data for this
Ligand-Target Pair