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SMILES: CN(C)C1CCN(CC1)c1ccc2[nH]c(nc2n1)C(=O)c1ccnc(c1)-c1c(C)n[nH]c1C

InChI Key: InChIKey=MGKFAGTZWMNNBL-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 107758   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cyclin-dependent kinase 4


(Oryctolagus cuniculus (Rabbit))		BDBM107758
PNG
(US8598217, 167)
Show SMILES CN(C)C1CCN(CC1)c1ccc2[nH]c(nc2n1)C(=O)c1ccnc(c1)-c1c(C)n[nH]c1C
Show InChI InChI=1S/C24H28N8O/c1-14-21(15(2)30-29-14)19-13-16(7-10-25-19)22(33)24-26-18-5-6-20(27-23(18)28-24)32-11-8-17(9-12-32)31(3)4/h5-7,10,13,17H,8-9,11-12H2,1-4H3,(H,29,30)(H,26,27,28)
UniProtKB/TrEMBL

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PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 195n/an/an/an/a7.5n/a



Astex Therapeutics Ltd.; Novartis AG

US Patent


Assay Description
A 384-well microtiter Lance TR-FRET (time-resolved-fluorescence energy transfer) endpoint assay was used for CDK4/cyclin D1 kinase activity measureme...

US Patent US8598217 (2013)


BindingDB Entry DOI: 10.7270/Q2BG2MN8
More data for this
Ligand-Target Pair